Systematic literature review and meta-analysis on the prevalence of rotavirus genotypes in Asia from 2015 to 2021
Understanding rotavirus prevalence by genotype can inform disease prevention and immunization decision-making. This systematic literature review summarized the genotype-specific prevalence of rotavirus in Asia from 2015 to 2021. We identified surveillance studies using PubMed, Embase, and Scopus dat...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2025.2500261 |
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| _version_ | 1849401762658648064 |
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| author | Tim Jesudason Kelly Fleetwood Maria Bermudez Oluwaseun Sharomi Hannah Schirrmacher Christian Hauck Daniel Hungerford David Tordrup Jelle Matthijnssens Cristina Carias |
| author_facet | Tim Jesudason Kelly Fleetwood Maria Bermudez Oluwaseun Sharomi Hannah Schirrmacher Christian Hauck Daniel Hungerford David Tordrup Jelle Matthijnssens Cristina Carias |
| author_sort | Tim Jesudason |
| collection | DOAJ |
| description | Understanding rotavirus prevalence by genotype can inform disease prevention and immunization decision-making. This systematic literature review summarized the genotype-specific prevalence of rotavirus in Asia from 2015 to 2021. We identified surveillance studies using PubMed, Embase, and Scopus databases, and used proportional meta-analysis (with the generic inverse variance method with arcsine transformation and generalized linear mixed models) to summarize genotype prevalence by region. A total of 7,601 studies were screened, and 73 studies from 16 countries were included. Data from 19,935 rotavirus samples reveal that the most common rotavirus genotypes circulating in Asia from 2015 to 2021 were G3P[8] (24%; 95% CI: 19%, 30%), G9P[8] (11%; 95% CI: 7%, 16%), G1P[8] (11%; 95% CI: 8%, 14%) and G2P[4] (8%; 95% CI: 6%, 10%). The results are comparable to estimates from the pre-vaccine licensure period. Surveillance based on sequencing data could help detect more subtle changes and further characterize the rotavirus burden in Asia. |
| format | Article |
| id | doaj-art-83af39f2c49845e5ae4bafd44301bfe7 |
| institution | Kabale University |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-83af39f2c49845e5ae4bafd44301bfe72025-08-20T03:37:42ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2025-12-0121110.1080/21645515.2025.2500261Systematic literature review and meta-analysis on the prevalence of rotavirus genotypes in Asia from 2015 to 2021Tim Jesudason0Kelly Fleetwood1Maria Bermudez2Oluwaseun Sharomi3Hannah Schirrmacher4Christian Hauck5Daniel Hungerford6David Tordrup7Jelle Matthijnssens8Cristina Carias9Triangulate Health Ltd., Doncaster, UKUsher Institute, University of Edinburgh, Edinburgh, UKTriangulate Health Ltd., Doncaster, UKBiostatistics and Research Decision Sciences (Health Economic and Decision Sciences), Merck & Co., Inc ., Rahway, NJ, USATriangulate Health Ltd., Doncaster, UKTriangulate Health Ltd., Doncaster, UKDepartment of Clinical Infection, Microbiology and Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UKTriangulate Health Ltd., Doncaster, UKKU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute, Laboratory of Clinical and Epidemiological Virology, Leuven, BelgiumValue and Implementation, Merck & Co., Inc, Rahway, NJ, USAUnderstanding rotavirus prevalence by genotype can inform disease prevention and immunization decision-making. This systematic literature review summarized the genotype-specific prevalence of rotavirus in Asia from 2015 to 2021. We identified surveillance studies using PubMed, Embase, and Scopus databases, and used proportional meta-analysis (with the generic inverse variance method with arcsine transformation and generalized linear mixed models) to summarize genotype prevalence by region. A total of 7,601 studies were screened, and 73 studies from 16 countries were included. Data from 19,935 rotavirus samples reveal that the most common rotavirus genotypes circulating in Asia from 2015 to 2021 were G3P[8] (24%; 95% CI: 19%, 30%), G9P[8] (11%; 95% CI: 7%, 16%), G1P[8] (11%; 95% CI: 8%, 14%) and G2P[4] (8%; 95% CI: 6%, 10%). The results are comparable to estimates from the pre-vaccine licensure period. Surveillance based on sequencing data could help detect more subtle changes and further characterize the rotavirus burden in Asia.https://www.tandfonline.com/doi/10.1080/21645515.2025.2500261Rotavirusvaccinationepidemiologychild healthdiarrhoea |
| spellingShingle | Tim Jesudason Kelly Fleetwood Maria Bermudez Oluwaseun Sharomi Hannah Schirrmacher Christian Hauck Daniel Hungerford David Tordrup Jelle Matthijnssens Cristina Carias Systematic literature review and meta-analysis on the prevalence of rotavirus genotypes in Asia from 2015 to 2021 Human Vaccines & Immunotherapeutics Rotavirus vaccination epidemiology child health diarrhoea |
| title | Systematic literature review and meta-analysis on the prevalence of rotavirus genotypes in Asia from 2015 to 2021 |
| title_full | Systematic literature review and meta-analysis on the prevalence of rotavirus genotypes in Asia from 2015 to 2021 |
| title_fullStr | Systematic literature review and meta-analysis on the prevalence of rotavirus genotypes in Asia from 2015 to 2021 |
| title_full_unstemmed | Systematic literature review and meta-analysis on the prevalence of rotavirus genotypes in Asia from 2015 to 2021 |
| title_short | Systematic literature review and meta-analysis on the prevalence of rotavirus genotypes in Asia from 2015 to 2021 |
| title_sort | systematic literature review and meta analysis on the prevalence of rotavirus genotypes in asia from 2015 to 2021 |
| topic | Rotavirus vaccination epidemiology child health diarrhoea |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2025.2500261 |
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