BaDuShengJi hydrogel accelerates diabetic wounds healing and regeneration of deep burn injury by anti-bacteria, anti-inflammation and promoting epithelialization
Bacterial infection, excessive inflammation, and delayed re-epithelialization are the biggest obstacles to diabetic wound healing and burn injuries. As a classic prescription, BaDuShengJi San (BDS) has been proven to accelerate chronic wound healing through anti-bacterial and anti-inflammatory mecha...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1580994/full |
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| author | Yuxiang Zhang Yuanyuan Yu Yuanyuan Yu Lien Yu Fang Wang Fang Wang Fuwei Yang Fuwei Yang Shiyu Liang Wen Xu Mengying Ji Yinuo Geng Jingwei Xue Chunmao Han Zhongtao Zhang Zhongtao Zhang Yilin Zhang Yilin Zhang Yilin Zhang |
| author_facet | Yuxiang Zhang Yuanyuan Yu Yuanyuan Yu Lien Yu Fang Wang Fang Wang Fuwei Yang Fuwei Yang Shiyu Liang Wen Xu Mengying Ji Yinuo Geng Jingwei Xue Chunmao Han Zhongtao Zhang Zhongtao Zhang Yilin Zhang Yilin Zhang Yilin Zhang |
| author_sort | Yuxiang Zhang |
| collection | DOAJ |
| description | Bacterial infection, excessive inflammation, and delayed re-epithelialization are the biggest obstacles to diabetic wound healing and burn injuries. As a classic prescription, BaDuShengJi San (BDS) has been proven to accelerate chronic wound healing through anti-bacterial and anti-inflammatory mechanisms. However, there are few reports on its role in preventing the malignant progression of deep burns or accelerating deep burn wound healing. Furthermore, the powder formulation of BDS has limited application scenarios, difficult dosage control, potential environmental pollution, and contradiction with the theory of moist wound healing, which has constrained its scope of application and efficacy to some extent. To address these issues, this study developed a novel hydrogel formulation incorporating BDS using carbomer 940 as the gel matrix, glycerol as a humectant, and triethanolamine as a pH adjuster, through orthogonal design. The results demonstrated that the prepared BDS-loaded gel (BDN) exhibited excellent stability and good biocompatibility, preserving the antibacterial and angiogenesis-promoting properties of BDS while enhancing its anti-inflammatory capabilities. Additionally, BDN significantly accelerated re-epithelialization in diabetic chronic wounds and burn wounds compared to BDS, achieving superior healing quality and mitigating renal damage associated with long-term BDS application. This study provides a comprehensive strategy for accelerating wound healing in diabetic chronic wounds and deep burn injuries and offers insights into expanding the clinical application of BDS and enhancing its therapeutic effects. |
| format | Article |
| id | doaj-art-83ad2b84dd584c1d95bf79c0a1994fdd |
| institution | DOAJ |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-83ad2b84dd584c1d95bf79c0a1994fdd2025-08-20T03:19:50ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-06-011610.3389/fphar.2025.15809941580994BaDuShengJi hydrogel accelerates diabetic wounds healing and regeneration of deep burn injury by anti-bacteria, anti-inflammation and promoting epithelializationYuxiang Zhang0Yuanyuan Yu1Yuanyuan Yu2Lien Yu3Fang Wang4Fang Wang5Fuwei Yang6Fuwei Yang7Shiyu Liang8Wen Xu9Mengying Ji10Yinuo Geng11Jingwei Xue12Chunmao Han13Zhongtao Zhang14Zhongtao Zhang15Yilin Zhang16Yilin Zhang17Yilin Zhang18Department of Burns and Wound Care Center, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaTumor Precise Intervention and Translational Medicine Laboratory, The Affiliated Taian City Central Hospital of Qingdao University, Taian, ChinaShandong Provincial Key Medical and Health Laboratory of Microenvironment-Responsive Biomedical Materials, Taian City Central Hospital, Taian, ChinaDepartment of Burns and Wound Care Center, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaTumor Precise Intervention and Translational Medicine Laboratory, The Affiliated Taian City Central Hospital of Qingdao University, Taian, ChinaShandong Provincial Key Medical and Health Laboratory of Microenvironment-Responsive Biomedical Materials, Taian City Central Hospital, Taian, ChinaTumor Precise Intervention and Translational Medicine Laboratory, The Affiliated Taian City Central Hospital of Qingdao University, Taian, ChinaShandong Provincial Key Medical and Health Laboratory of Microenvironment-Responsive Biomedical Materials, Taian City Central Hospital, Taian, ChinaDepartment of Nursing Division, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Nursing Division, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Nursing Division, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Nursing, Taishan Vocational College of Nursing, Taian, ChinaTumor Precise Intervention and Translational Medicine Laboratory, The Affiliated Taian City Central Hospital of Qingdao University, Taian, ChinaDepartment of Burns and Wound Care Center, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Burns and Wound Care Center, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaTumor Precise Intervention and Translational Medicine Laboratory, The Affiliated Taian City Central Hospital of Qingdao University, Taian, ChinaTaishan Academy of Medical Sciences, The Affiliated Taian City Central Hospital of Qingdao University, Taian, ChinaPostdoctoral Mobile Station, Shandong University of Traditional Chinese Medicine, Jinan, ChinaAffiliated Hospital of Shandong Institute of Traditional Chinese Medicine, Jinan, ChinaBacterial infection, excessive inflammation, and delayed re-epithelialization are the biggest obstacles to diabetic wound healing and burn injuries. As a classic prescription, BaDuShengJi San (BDS) has been proven to accelerate chronic wound healing through anti-bacterial and anti-inflammatory mechanisms. However, there are few reports on its role in preventing the malignant progression of deep burns or accelerating deep burn wound healing. Furthermore, the powder formulation of BDS has limited application scenarios, difficult dosage control, potential environmental pollution, and contradiction with the theory of moist wound healing, which has constrained its scope of application and efficacy to some extent. To address these issues, this study developed a novel hydrogel formulation incorporating BDS using carbomer 940 as the gel matrix, glycerol as a humectant, and triethanolamine as a pH adjuster, through orthogonal design. The results demonstrated that the prepared BDS-loaded gel (BDN) exhibited excellent stability and good biocompatibility, preserving the antibacterial and angiogenesis-promoting properties of BDS while enhancing its anti-inflammatory capabilities. Additionally, BDN significantly accelerated re-epithelialization in diabetic chronic wounds and burn wounds compared to BDS, achieving superior healing quality and mitigating renal damage associated with long-term BDS application. This study provides a comprehensive strategy for accelerating wound healing in diabetic chronic wounds and deep burn injuries and offers insights into expanding the clinical application of BDS and enhancing its therapeutic effects.https://www.frontiersin.org/articles/10.3389/fphar.2025.1580994/fullBaDuShengJi Sanwound healingdiabetic wounddeep burn injuryanti-bacteriaanti‐inflammation |
| spellingShingle | Yuxiang Zhang Yuanyuan Yu Yuanyuan Yu Lien Yu Fang Wang Fang Wang Fuwei Yang Fuwei Yang Shiyu Liang Wen Xu Mengying Ji Yinuo Geng Jingwei Xue Chunmao Han Zhongtao Zhang Zhongtao Zhang Yilin Zhang Yilin Zhang Yilin Zhang BaDuShengJi hydrogel accelerates diabetic wounds healing and regeneration of deep burn injury by anti-bacteria, anti-inflammation and promoting epithelialization Frontiers in Pharmacology BaDuShengJi San wound healing diabetic wound deep burn injury anti-bacteria anti‐inflammation |
| title | BaDuShengJi hydrogel accelerates diabetic wounds healing and regeneration of deep burn injury by anti-bacteria, anti-inflammation and promoting epithelialization |
| title_full | BaDuShengJi hydrogel accelerates diabetic wounds healing and regeneration of deep burn injury by anti-bacteria, anti-inflammation and promoting epithelialization |
| title_fullStr | BaDuShengJi hydrogel accelerates diabetic wounds healing and regeneration of deep burn injury by anti-bacteria, anti-inflammation and promoting epithelialization |
| title_full_unstemmed | BaDuShengJi hydrogel accelerates diabetic wounds healing and regeneration of deep burn injury by anti-bacteria, anti-inflammation and promoting epithelialization |
| title_short | BaDuShengJi hydrogel accelerates diabetic wounds healing and regeneration of deep burn injury by anti-bacteria, anti-inflammation and promoting epithelialization |
| title_sort | badushengji hydrogel accelerates diabetic wounds healing and regeneration of deep burn injury by anti bacteria anti inflammation and promoting epithelialization |
| topic | BaDuShengJi San wound healing diabetic wound deep burn injury anti-bacteria anti‐inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1580994/full |
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