Novel CSF β-synuclein-specific assays signal early synaptic degeneration in Alzheimer’s disease

Novel CSF β-synuclein-specific assays signal early synaptic degeneration in Alzheimer’s disease

Abstract Background Beta-synuclein (β-syn), measured at N-terminal epitopes, is an emerging cerebrospinal fluid (CSF) biomarker for synaptic degeneration in Alzheimer's disease (AD). Targeting the mid-region or C-terminus of β-syn may enhance analytical specificity due to the distinct structure...

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Bibliographic Details
Main Authors: Sherif Bayoumy, Julie Goossens, Charlotte De Rocker, Senna Y. Sie, Nolan J. Barrett, Wiesje M. van der Flier, Charlotte E. Teunissen, Eugeen Vanmechelen, Inge M. W. Verberk
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer´s disease
Preclinical alzheimer's disease
CSF biomarker
β-Synuclein
Synaptic degeneration
Novel ELISAs
Online Access:https://doi.org/10.1186/s13195-025-01716-8
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