Analysis of possible markers of effective antitumor cellular immune response before starting therapy with immune check-point inhibitors
The aim of the study. to analyse possible markers of an effective antitumor cellular immune response.Material and methods. using the keywords «checkpoint inhibitors, immunotherapy, t-lymphocytes, exhausted t-lymphocytes, anti-tumor immune response», review and original articles (n=34) published from...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2022-05-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/2096 |
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| author | A. M. Malkova R. V. Orlova N. V. Zhukova A. R. Gubal V. V. Sharoiko |
| author_facet | A. M. Malkova R. V. Orlova N. V. Zhukova A. R. Gubal V. V. Sharoiko |
| author_sort | A. M. Malkova |
| collection | DOAJ |
| description | The aim of the study. to analyse possible markers of an effective antitumor cellular immune response.Material and methods. using the keywords «checkpoint inhibitors, immunotherapy, t-lymphocytes, exhausted t-lymphocytes, anti-tumor immune response», review and original articles (n=34) published from 2005 to 2020 in the Pubmed, Web Of Science, Elsevier databases were selected.Results. the study revealed possible markers reflecting a high activity of an adaptive immune response based on effective recognition of tumor antigens through MHC molecules, a sufficient number of T-lymphocytes and a predominance of T-cytotoxic cells, as well as a low level of expression of inhibitory receptors and small molecules. the presence of single nucleotide polymorphisms in the HLA-I and HLA-II genes encoding MHC-I and MHC-II proteins, respectively, a high level of lymphocytes, among which the most important is the predominance of CD8+ t cells and a low level of T-regulatory cells (T-reg), as well as the presence of single nucleotide polymorphisms in the genes encoding FcγR receptors of T-lymphocytes showed their predictive significance. the diagnostic significance of determining the expression of inhibitory receptors for T-lymphocytes (TIM3, LAG3, TIGIT), especially in combination with the determination of PD-1 expression, was also revealed.Conclusion. the results obtained may be relevant for applying new methods for the assessment of the functional activity of the T-cell immune response before starting therapy with checkpoint inhibitors, as well as for the development of new diagnostic panels, which may be of interest to employees of clinical diagnostic laboratories and research centers. |
| format | Article |
| id | doaj-art-83a87cfbc41746d5aa47ffec7e0dd23d |
| institution | DOAJ |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2022-05-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-83a87cfbc41746d5aa47ffec7e0dd23d2025-08-20T03:18:24ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682022-05-0121210911710.21294/1814-4861-2022-21-2-109-117985Analysis of possible markers of effective antitumor cellular immune response before starting therapy with immune check-point inhibitorsA. M. Malkova0R. V. Orlova1N. V. Zhukova2A. R. Gubal3V. V. Sharoiko4Saint Petersburg State UniversitySaint Petersburg State University; Saint Petersburg Clinical Oncology CenterSaint Petersburg State University; Saint Petersburg Clinical Oncology CenterSaint Petersburg State UniversitySaint Petersburg State University; Pavlov First Saint Petersburg State Medical UniversityThe aim of the study. to analyse possible markers of an effective antitumor cellular immune response.Material and methods. using the keywords «checkpoint inhibitors, immunotherapy, t-lymphocytes, exhausted t-lymphocytes, anti-tumor immune response», review and original articles (n=34) published from 2005 to 2020 in the Pubmed, Web Of Science, Elsevier databases were selected.Results. the study revealed possible markers reflecting a high activity of an adaptive immune response based on effective recognition of tumor antigens through MHC molecules, a sufficient number of T-lymphocytes and a predominance of T-cytotoxic cells, as well as a low level of expression of inhibitory receptors and small molecules. the presence of single nucleotide polymorphisms in the HLA-I and HLA-II genes encoding MHC-I and MHC-II proteins, respectively, a high level of lymphocytes, among which the most important is the predominance of CD8+ t cells and a low level of T-regulatory cells (T-reg), as well as the presence of single nucleotide polymorphisms in the genes encoding FcγR receptors of T-lymphocytes showed their predictive significance. the diagnostic significance of determining the expression of inhibitory receptors for T-lymphocytes (TIM3, LAG3, TIGIT), especially in combination with the determination of PD-1 expression, was also revealed.Conclusion. the results obtained may be relevant for applying new methods for the assessment of the functional activity of the T-cell immune response before starting therapy with checkpoint inhibitors, as well as for the development of new diagnostic panels, which may be of interest to employees of clinical diagnostic laboratories and research centers.https://www.siboncoj.ru/jour/article/view/2096tumoradaptive immune responsebiomarkersefficacyantitumor therapy |
| spellingShingle | A. M. Malkova R. V. Orlova N. V. Zhukova A. R. Gubal V. V. Sharoiko Analysis of possible markers of effective antitumor cellular immune response before starting therapy with immune check-point inhibitors Сибирский онкологический журнал tumor adaptive immune response biomarkers efficacy antitumor therapy |
| title | Analysis of possible markers of effective antitumor cellular immune response before starting therapy with immune check-point inhibitors |
| title_full | Analysis of possible markers of effective antitumor cellular immune response before starting therapy with immune check-point inhibitors |
| title_fullStr | Analysis of possible markers of effective antitumor cellular immune response before starting therapy with immune check-point inhibitors |
| title_full_unstemmed | Analysis of possible markers of effective antitumor cellular immune response before starting therapy with immune check-point inhibitors |
| title_short | Analysis of possible markers of effective antitumor cellular immune response before starting therapy with immune check-point inhibitors |
| title_sort | analysis of possible markers of effective antitumor cellular immune response before starting therapy with immune check point inhibitors |
| topic | tumor adaptive immune response biomarkers efficacy antitumor therapy |
| url | https://www.siboncoj.ru/jour/article/view/2096 |
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