Advances in non-small cell lung cancer mechanomedicine: deciphering the signaling networks that govern tumor-TME interactions
Abstract Cells from the tumor microenvironment (TME) interact with tumor cells in non-small cell lung cancer (NSCLC) to form a reciprocal crosstalk which influences tumor growth, proliferation, metastasis and multidrug response. This crosstalk is modulated by TME mechanical inputs, which elicit the...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
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| Online Access: | https://doi.org/10.1186/s13046-024-03242-1 |
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| author | Antonios N. Gargalionis Kostas A. Papavassiliou Efthimia K. Basdra Athanasios G. Papavassiliou |
| author_facet | Antonios N. Gargalionis Kostas A. Papavassiliou Efthimia K. Basdra Athanasios G. Papavassiliou |
| author_sort | Antonios N. Gargalionis |
| collection | DOAJ |
| description | Abstract Cells from the tumor microenvironment (TME) interact with tumor cells in non-small cell lung cancer (NSCLC) to form a reciprocal crosstalk which influences tumor growth, proliferation, metastasis and multidrug response. This crosstalk is modulated by TME mechanical inputs, which elicit the processes of mechanosensing and mechanotransduction. Recent advances in unveiling these signaling networks establish the interdisciplinary field of mechanomedicine to exploit emerging diagnostic, predictive and therapeutic tools for more effective NSCLC treatments. |
| format | Article |
| id | doaj-art-83a5f145b8234f7c8a265bc530ec6c3b |
| institution | OA Journals |
| issn | 1756-9966 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj-art-83a5f145b8234f7c8a265bc530ec6c3b2025-08-20T02:38:35ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662024-11-014311510.1186/s13046-024-03242-1Advances in non-small cell lung cancer mechanomedicine: deciphering the signaling networks that govern tumor-TME interactionsAntonios N. Gargalionis0Kostas A. Papavassiliou1Efthimia K. Basdra2Athanasios G. Papavassiliou3Laboratory of Clinical Biochemistry, Medical School, ‘Attikon’ University General Hospital, National and Kapodistrian University of AthensFirst University Department of Respiratory Medicine, Medical School, ‘Sotiria’ Chest Hospital, National and Kapodistrian University of AthensDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of AthensDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of AthensAbstract Cells from the tumor microenvironment (TME) interact with tumor cells in non-small cell lung cancer (NSCLC) to form a reciprocal crosstalk which influences tumor growth, proliferation, metastasis and multidrug response. This crosstalk is modulated by TME mechanical inputs, which elicit the processes of mechanosensing and mechanotransduction. Recent advances in unveiling these signaling networks establish the interdisciplinary field of mechanomedicine to exploit emerging diagnostic, predictive and therapeutic tools for more effective NSCLC treatments.https://doi.org/10.1186/s13046-024-03242-1Non-small cell lung cancerTumor microenvironmentMechanomedicineMechanosignalingMechanotransductionYAP |
| spellingShingle | Antonios N. Gargalionis Kostas A. Papavassiliou Efthimia K. Basdra Athanasios G. Papavassiliou Advances in non-small cell lung cancer mechanomedicine: deciphering the signaling networks that govern tumor-TME interactions Journal of Experimental & Clinical Cancer Research Non-small cell lung cancer Tumor microenvironment Mechanomedicine Mechanosignaling Mechanotransduction YAP |
| title | Advances in non-small cell lung cancer mechanomedicine: deciphering the signaling networks that govern tumor-TME interactions |
| title_full | Advances in non-small cell lung cancer mechanomedicine: deciphering the signaling networks that govern tumor-TME interactions |
| title_fullStr | Advances in non-small cell lung cancer mechanomedicine: deciphering the signaling networks that govern tumor-TME interactions |
| title_full_unstemmed | Advances in non-small cell lung cancer mechanomedicine: deciphering the signaling networks that govern tumor-TME interactions |
| title_short | Advances in non-small cell lung cancer mechanomedicine: deciphering the signaling networks that govern tumor-TME interactions |
| title_sort | advances in non small cell lung cancer mechanomedicine deciphering the signaling networks that govern tumor tme interactions |
| topic | Non-small cell lung cancer Tumor microenvironment Mechanomedicine Mechanosignaling Mechanotransduction YAP |
| url | https://doi.org/10.1186/s13046-024-03242-1 |
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