Regulation of normal human polyrnorphonuclear leucocytes by carnitine
The effect of carnitine, a drug that plays an essential role in mitochondria metabolism, on some of the most important human polymorphonuclear leucocytes (PMN) activation steps including modulation of adhesion molecule density, reactive oxygen species production, and tumour necrosis factor-α (TNFα)...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1993-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935193000742 |
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| _version_ | 1849403774173446144 |
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| author | Andrea Fattorossi Roberto Biselli Anna Casciaro Sonia Tzantzoglou Claudio de Simone |
| author_facet | Andrea Fattorossi Roberto Biselli Anna Casciaro Sonia Tzantzoglou Claudio de Simone |
| author_sort | Andrea Fattorossi |
| collection | DOAJ |
| description | The effect of carnitine, a drug that plays an essential role in mitochondria metabolism, on some of the most important human polymorphonuclear leucocytes (PMN) activation steps including modulation of adhesion molecule density, reactive oxygen species production, and tumour necrosis factor-α (TNFα) production was investigated. The capability of carnitine in protecting PMN from deter ioration on storage was also studied. Data shows that carnitine exerts considerable effects on all PMN functions investigated. Although the ultimate effect was often donor dependent, TNFα production was exceptional in that carnitine was able to consistently reduce TNFα production in Staphylococcus aureus stimulated PMN in a clear dose-dependent fashion. It is concluded that carnitine may represent a useful active agent in situations characterized by PMN mobilization/activation. |
| format | Article |
| id | doaj-art-83a1fac51ec445f7b15b2be1976e7ed3 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1993-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-83a1fac51ec445f7b15b2be1976e7ed32025-08-20T03:37:11ZengWileyMediators of Inflammation0962-93511466-18611993-01-0127S37S4110.1155/S0962935193000742Regulation of normal human polyrnorphonuclear leucocytes by carnitineAndrea Fattorossi0Roberto Biselli1Anna Casciaro2Sonia Tzantzoglou3Claudio de Simone4Rep. Medicina, Lab. Immunologia, Pratica di Mare, Pomezia, Roma, ItalyRep. Medicina, Lab. Immunologia, Pratica di Mare, Pomezia, Roma, ItalyRep. Medicina, Lab. Immunologia, Pratica di Mare, Pomezia, Roma, ItalyCattedra Malattie Infettive, Universitá “La Sapienza” Roma, ItalyCattedra Malattie Infettive, Universitá di L'Aquila, ItalyThe effect of carnitine, a drug that plays an essential role in mitochondria metabolism, on some of the most important human polymorphonuclear leucocytes (PMN) activation steps including modulation of adhesion molecule density, reactive oxygen species production, and tumour necrosis factor-α (TNFα) production was investigated. The capability of carnitine in protecting PMN from deter ioration on storage was also studied. Data shows that carnitine exerts considerable effects on all PMN functions investigated. Although the ultimate effect was often donor dependent, TNFα production was exceptional in that carnitine was able to consistently reduce TNFα production in Staphylococcus aureus stimulated PMN in a clear dose-dependent fashion. It is concluded that carnitine may represent a useful active agent in situations characterized by PMN mobilization/activation.http://dx.doi.org/10.1155/S0962935193000742 |
| spellingShingle | Andrea Fattorossi Roberto Biselli Anna Casciaro Sonia Tzantzoglou Claudio de Simone Regulation of normal human polyrnorphonuclear leucocytes by carnitine Mediators of Inflammation |
| title | Regulation of normal human polyrnorphonuclear leucocytes by carnitine |
| title_full | Regulation of normal human polyrnorphonuclear leucocytes by carnitine |
| title_fullStr | Regulation of normal human polyrnorphonuclear leucocytes by carnitine |
| title_full_unstemmed | Regulation of normal human polyrnorphonuclear leucocytes by carnitine |
| title_short | Regulation of normal human polyrnorphonuclear leucocytes by carnitine |
| title_sort | regulation of normal human polyrnorphonuclear leucocytes by carnitine |
| url | http://dx.doi.org/10.1155/S0962935193000742 |
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