Patient Selection for the Use of Niraparib in Advanced Ovarian Cancer: A Review
Anna Gonzalez,1 Quinn Kistenfeger,2 Casey M Cosgrove1 1Division of Gynecologic Oncology; The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute, Columbus, OH, USA; 2Division of Obstetrics & Gynecology; The Ohio State University, Columbus, OH,...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2024-12-01
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| Series: | International Journal of Women's Health |
| Subjects: | |
| Online Access: | https://www.dovepress.com/patient-selection-for-the-use-of-niraparib-in-advanced-ovarian-cancer--peer-reviewed-fulltext-article-IJWH |
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| Summary: | Anna Gonzalez,1 Quinn Kistenfeger,2 Casey M Cosgrove1 1Division of Gynecologic Oncology; The Ohio State University Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute, Columbus, OH, USA; 2Division of Obstetrics & Gynecology; The Ohio State University, Columbus, OH, USACorrespondence: Anna Gonzalez, Email anna.gonzalez@osumc.eduAbstract: The advent of poly(ADP-ribose) polymerase (PARP) inhibitors has resulted in a significant paradigm shift in ovarian cancer treatment. Niraparib, a potent PARP inhibitor, has demonstrated substantial efficacy in both first-line and recurrent disease settings. By targeting homologous recombination DNA repair, a pathway frequently disrupted in ovarian cancer, particularly in the context of BRCA mutations, niraparib induces synthetic lethality. Pivotal clinical trials, including PRIMA, ENGOT-OV16/NOVA, and QUADRA, have solidified niraparib’s role in the treatment paradigm. While sharing a common mechanism of action with other PARP inhibitors, niraparib exhibits a distinct toxicity profile. Notably, hematologic toxicities, particularly thrombocytopenia, and hypertension have been observed at Grade 3– 4 levels. A comprehensive understanding of niraparib’s efficacy and safety is essential for optimal patient selection and management.Keywords: Niraparib, ovarian cancer, maintenance therapy, recurrent |
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| ISSN: | 1179-1411 |