Systematic review and meta-analysis of the association between biofilm formation and antibiotic resistance in MRSE Isolated from Iranian patients
Background: Biofilms are organized communities of microorganisms encased in a self-produced matrix that adheres to surfaces and can have both beneficial and detrimental effects in various environments. These biofilms have been linked to severe infections in humans. We investigated the association be...
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Babol University of Medical Sciences
2025-03-01
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| Series: | Caspian Journal of Internal Medicine |
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| Online Access: | http://caspjim.com/article-1-4011-en.pdf |
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| author | Parisa Behshood Elaheh Tajbakhsh |
| author_facet | Parisa Behshood Elaheh Tajbakhsh |
| author_sort | Parisa Behshood |
| collection | DOAJ |
| description | Background: Biofilms are organized communities of microorganisms encased in a self-produced matrix that adheres to surfaces and can have both beneficial and detrimental effects in various environments. These biofilms have been linked to severe infections in humans. We investigated the association between antibiotic resistance and biofilm formation in methicillin-resistant Staphylococcus epidermidis (MRSE) isolates.
Methods: A comprehensive search was conducted through data medical data bases using a combination of mesh terms. The data were analyzed using STATA meta-analysis software, and a random effects model was employed to determine the pooled prevalence with a 95% confidence interval (CI).
Results: Our findings revealed that the prevalence of MRSA was 61.75% (95% CI: 35.6-99.1). The cumulative rate of biofilm formation in MRSE strains was reported to be 83.4% (95% CI: 47.8-99.4). Among the biofilm-related genes, the SdrG gene exhibited the highest frequency (98%), followed by the atlG gene with a frequency of 84%.
Conclusion: Out of the seven, three documented a positive association. Given the propensity of MRSE strains to form biofilms, it is crucial to implement preventive measures against infections caused by these strains. |
| format | Article |
| id | doaj-art-83a01cb7f9fa48188e857895a161b4fc |
| institution | DOAJ |
| issn | 2008-6164 2008-6172 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Internal Medicine |
| spelling | doaj-art-83a01cb7f9fa48188e857895a161b4fc2025-08-20T03:17:51ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722025-03-01162225232Systematic review and meta-analysis of the association between biofilm formation and antibiotic resistance in MRSE Isolated from Iranian patientsParisa Behshood0Elaheh Tajbakhsh1 Department of Biology, Islamic Azad University, Shahrekord Unit, Shahrekord, Iran Department of Biology, Islamic Azad University, Shahrekord Unit, Shahrekord, Iran Background: Biofilms are organized communities of microorganisms encased in a self-produced matrix that adheres to surfaces and can have both beneficial and detrimental effects in various environments. These biofilms have been linked to severe infections in humans. We investigated the association between antibiotic resistance and biofilm formation in methicillin-resistant Staphylococcus epidermidis (MRSE) isolates. Methods: A comprehensive search was conducted through data medical data bases using a combination of mesh terms. The data were analyzed using STATA meta-analysis software, and a random effects model was employed to determine the pooled prevalence with a 95% confidence interval (CI). Results: Our findings revealed that the prevalence of MRSA was 61.75% (95% CI: 35.6-99.1). The cumulative rate of biofilm formation in MRSE strains was reported to be 83.4% (95% CI: 47.8-99.4). Among the biofilm-related genes, the SdrG gene exhibited the highest frequency (98%), followed by the atlG gene with a frequency of 84%. Conclusion: Out of the seven, three documented a positive association. Given the propensity of MRSE strains to form biofilms, it is crucial to implement preventive measures against infections caused by these strains.http://caspjim.com/article-1-4011-en.pdfbiofilmantibiotic resistancecorrelationmethicillin-resistant staphylococcus epidermidis |
| spellingShingle | Parisa Behshood Elaheh Tajbakhsh Systematic review and meta-analysis of the association between biofilm formation and antibiotic resistance in MRSE Isolated from Iranian patients Caspian Journal of Internal Medicine biofilm antibiotic resistance correlation methicillin-resistant staphylococcus epidermidis |
| title | Systematic review and meta-analysis of the association between biofilm formation and antibiotic resistance in MRSE Isolated from Iranian patients |
| title_full | Systematic review and meta-analysis of the association between biofilm formation and antibiotic resistance in MRSE Isolated from Iranian patients |
| title_fullStr | Systematic review and meta-analysis of the association between biofilm formation and antibiotic resistance in MRSE Isolated from Iranian patients |
| title_full_unstemmed | Systematic review and meta-analysis of the association between biofilm formation and antibiotic resistance in MRSE Isolated from Iranian patients |
| title_short | Systematic review and meta-analysis of the association between biofilm formation and antibiotic resistance in MRSE Isolated from Iranian patients |
| title_sort | systematic review and meta analysis of the association between biofilm formation and antibiotic resistance in mrse isolated from iranian patients |
| topic | biofilm antibiotic resistance correlation methicillin-resistant staphylococcus epidermidis |
| url | http://caspjim.com/article-1-4011-en.pdf |
| work_keys_str_mv | AT parisabehshood systematicreviewandmetaanalysisoftheassociationbetweenbiofilmformationandantibioticresistanceinmrseisolatedfromiranianpatients AT elahehtajbakhsh systematicreviewandmetaanalysisoftheassociationbetweenbiofilmformationandantibioticresistanceinmrseisolatedfromiranianpatients |