Comparative efficacy and safety of targeted narrowband ultraviolet B, 308-nm excimer laser, and 308-nm excimer lamp in vitiligo: a retrospective study
Background Data directly comparing targeted narrowband ultraviolet B (NB-UVB), 308-nm excimer laser, and 308-nm excimer lamp for vitiligo are limited.Objectives We compared the efficacy and safety of these three modalities in vitiligo.Methods In this retrospective study, we reviewed the medical reco...
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Taylor & Francis Group
2025-12-01
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| Series: | Journal of Dermatological Treatment |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09546634.2025.2514637 |
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| author | Thamonwan Tantivithiwate Chayada Chaiyabutr Chanisada Wongpraparut Punyanut Yothachai Nuttaporn Nuntawisuttiwong Narumol Silpa-archa |
| author_facet | Thamonwan Tantivithiwate Chayada Chaiyabutr Chanisada Wongpraparut Punyanut Yothachai Nuttaporn Nuntawisuttiwong Narumol Silpa-archa |
| author_sort | Thamonwan Tantivithiwate |
| collection | DOAJ |
| description | Background Data directly comparing targeted narrowband ultraviolet B (NB-UVB), 308-nm excimer laser, and 308-nm excimer lamp for vitiligo are limited.Objectives We compared the efficacy and safety of these three modalities in vitiligo.Methods In this retrospective study, we reviewed the medical records of vitiligo patients at the Photodermatology Clinic, Siriraj Hospital. Patients received either targeted NB-UVB (group A), a 308-nm excimer laser (group B), or a 308-nm excimer lamp (group C), administered two to three times per week for at least 3 months. Photographs taken before and after therapy were evaluated. The primary outcome was repigmentation, graded on a five-tier scale: poor (0–25%), fair (26–50%), good (51–75%), very good (76–90%), and excellent (91–100%). The secondary outcome was treatment-related adverse events.Results No statistically significant differences in efficacy were observed among the three groups, indicated by a very good to excellent response in 42.4% (group A), 17.6% (group B), and 29.4% (group C). Although group A showed higher response rates at 3 and 6 months, differences were not significant. Adverse effects were significantly more frequent in group C.Conclusions All three devices demonstrated comparable efficacy and promoted rapid repigmentation. However, the excimer lamp had the highest rate of adverse effects. |
| format | Article |
| id | doaj-art-839e367915c8404db648df81e7fe80f7 |
| institution | Kabale University |
| issn | 0954-6634 1471-1753 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj-art-839e367915c8404db648df81e7fe80f72025-08-20T03:45:41ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532025-12-0136110.1080/09546634.2025.2514637Comparative efficacy and safety of targeted narrowband ultraviolet B, 308-nm excimer laser, and 308-nm excimer lamp in vitiligo: a retrospective studyThamonwan Tantivithiwate0Chayada Chaiyabutr1Chanisada Wongpraparut2Punyanut Yothachai3Nuttaporn Nuntawisuttiwong4Narumol Silpa-archa5Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandBackground Data directly comparing targeted narrowband ultraviolet B (NB-UVB), 308-nm excimer laser, and 308-nm excimer lamp for vitiligo are limited.Objectives We compared the efficacy and safety of these three modalities in vitiligo.Methods In this retrospective study, we reviewed the medical records of vitiligo patients at the Photodermatology Clinic, Siriraj Hospital. Patients received either targeted NB-UVB (group A), a 308-nm excimer laser (group B), or a 308-nm excimer lamp (group C), administered two to three times per week for at least 3 months. Photographs taken before and after therapy were evaluated. The primary outcome was repigmentation, graded on a five-tier scale: poor (0–25%), fair (26–50%), good (51–75%), very good (76–90%), and excellent (91–100%). The secondary outcome was treatment-related adverse events.Results No statistically significant differences in efficacy were observed among the three groups, indicated by a very good to excellent response in 42.4% (group A), 17.6% (group B), and 29.4% (group C). Although group A showed higher response rates at 3 and 6 months, differences were not significant. Adverse effects were significantly more frequent in group C.Conclusions All three devices demonstrated comparable efficacy and promoted rapid repigmentation. However, the excimer lamp had the highest rate of adverse effects.https://www.tandfonline.com/doi/10.1080/09546634.2025.2514637308-nm excimer lamp308-nm excimer lasertargeted NB-UVBtargeted phototherapyvitiligo |
| spellingShingle | Thamonwan Tantivithiwate Chayada Chaiyabutr Chanisada Wongpraparut Punyanut Yothachai Nuttaporn Nuntawisuttiwong Narumol Silpa-archa Comparative efficacy and safety of targeted narrowband ultraviolet B, 308-nm excimer laser, and 308-nm excimer lamp in vitiligo: a retrospective study Journal of Dermatological Treatment 308-nm excimer lamp 308-nm excimer laser targeted NB-UVB targeted phototherapy vitiligo |
| title | Comparative efficacy and safety of targeted narrowband ultraviolet B, 308-nm excimer laser, and 308-nm excimer lamp in vitiligo: a retrospective study |
| title_full | Comparative efficacy and safety of targeted narrowband ultraviolet B, 308-nm excimer laser, and 308-nm excimer lamp in vitiligo: a retrospective study |
| title_fullStr | Comparative efficacy and safety of targeted narrowband ultraviolet B, 308-nm excimer laser, and 308-nm excimer lamp in vitiligo: a retrospective study |
| title_full_unstemmed | Comparative efficacy and safety of targeted narrowband ultraviolet B, 308-nm excimer laser, and 308-nm excimer lamp in vitiligo: a retrospective study |
| title_short | Comparative efficacy and safety of targeted narrowband ultraviolet B, 308-nm excimer laser, and 308-nm excimer lamp in vitiligo: a retrospective study |
| title_sort | comparative efficacy and safety of targeted narrowband ultraviolet b 308 nm excimer laser and 308 nm excimer lamp in vitiligo a retrospective study |
| topic | 308-nm excimer lamp 308-nm excimer laser targeted NB-UVB targeted phototherapy vitiligo |
| url | https://www.tandfonline.com/doi/10.1080/09546634.2025.2514637 |
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