Heterogeneity and distribution characteristics of tertiary lymphoid structures predict prognostic outcome in esophageal squamous cell carcinoma

Heterogeneity and distribution characteristics of tertiary lymphoid structures predict prognostic outcome in esophageal squamous cell carcinoma

ObjectiveTertiary Lymphoid Structures (TLSs) are ectopic lymphoid aggregates that form within the tumor microenvironment (TME) and are increasingly recognized as potential prognostic biomarkers in various cancers. However, the spatial heterogeneity and prognostic value of TLSs in esophageal squamous...

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Bibliographic Details
Main Authors:	Chengjuan Zhang, Ruihua Bai, Yanping Hu, Tao Wang, Bin Ma, Junxia Zhang, Jing Yuan, Xiance Tang, He Zhang, Tingjie Wang, Yuxi Chang, Qingxin Xia, Bing Wei
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-08-01
Series:	Frontiers in Immunology
Subjects:	esophageal cancer tertiary lymphoid structures heterogeneity prognosis their heterogeneity in esophageal squamous univariate analysis revealed that T stage N stage TG
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1606499/full
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