Latest update on the use of recombinant growth factors for periodontal regeneration: existing evidence and clinical applications
Growth factors were introduced to increase predictability in periodontal regeneration and have since been widely applied in dentistry. This narrative review article highlights histological and latest findings of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and recombinant human fi...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-11-01
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| Series: | Therapeutic Advances in Chronic Disease |
| Online Access: | https://doi.org/10.1177/20406223241302707 |
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| author | Anahat Khehra Takahiko Shiba Chia-Yu Chen David M. Kim |
| author_facet | Anahat Khehra Takahiko Shiba Chia-Yu Chen David M. Kim |
| author_sort | Anahat Khehra |
| collection | DOAJ |
| description | Growth factors were introduced to increase predictability in periodontal regeneration and have since been widely applied in dentistry. This narrative review article highlights histological and latest findings of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and recombinant human fibroblast growth factor-2 (rhFGF-2) for periodontal regeneration. rhPDGF-BB enhances the proliferation and chemotaxis of periodontal ligament and alveolar bone cells. The optimal dose for rhPDGF-BB, in combination with beta-tricalcium phosphate, is 0.3 mg/ml. It is approved in the United States, Canada, and Taiwan for use in periodontal regeneration and treatment of gingival recession. rhFGF-2 promotes periodontal wound healing through mitogenic and angiogenic effects on mesenchymal cells in the periodontal ligament. It is approved in Japan at an optimal dose of 0.3% for periodontal regeneration in intrabony defects. Both recombinant growth factors show histological evidence of new bone, cementum, and periodontal ligament. Clinical studies demonstrate improved clinical attachment levels and defect resolution for treating intrabony and furcation periodontal defects. Presented clinical cases and consensus reports may serve as a reference for clinicians. rhPDGF-BB and rhFGF-2 are safe and effective biologics that can be applied to improve the outcomes of periodontal regeneration. |
| format | Article |
| id | doaj-art-8388b3c7ab2e4592938e82df9396f66a |
| institution | OA Journals |
| issn | 2040-6231 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Chronic Disease |
| spelling | doaj-art-8388b3c7ab2e4592938e82df9396f66a2025-08-20T01:52:54ZengSAGE PublishingTherapeutic Advances in Chronic Disease2040-62312024-11-011510.1177/20406223241302707Latest update on the use of recombinant growth factors for periodontal regeneration: existing evidence and clinical applicationsAnahat KhehraTakahiko ShibaChia-Yu ChenDavid M. KimGrowth factors were introduced to increase predictability in periodontal regeneration and have since been widely applied in dentistry. This narrative review article highlights histological and latest findings of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) and recombinant human fibroblast growth factor-2 (rhFGF-2) for periodontal regeneration. rhPDGF-BB enhances the proliferation and chemotaxis of periodontal ligament and alveolar bone cells. The optimal dose for rhPDGF-BB, in combination with beta-tricalcium phosphate, is 0.3 mg/ml. It is approved in the United States, Canada, and Taiwan for use in periodontal regeneration and treatment of gingival recession. rhFGF-2 promotes periodontal wound healing through mitogenic and angiogenic effects on mesenchymal cells in the periodontal ligament. It is approved in Japan at an optimal dose of 0.3% for periodontal regeneration in intrabony defects. Both recombinant growth factors show histological evidence of new bone, cementum, and periodontal ligament. Clinical studies demonstrate improved clinical attachment levels and defect resolution for treating intrabony and furcation periodontal defects. Presented clinical cases and consensus reports may serve as a reference for clinicians. rhPDGF-BB and rhFGF-2 are safe and effective biologics that can be applied to improve the outcomes of periodontal regeneration.https://doi.org/10.1177/20406223241302707 |
| spellingShingle | Anahat Khehra Takahiko Shiba Chia-Yu Chen David M. Kim Latest update on the use of recombinant growth factors for periodontal regeneration: existing evidence and clinical applications Therapeutic Advances in Chronic Disease |
| title | Latest update on the use of recombinant growth factors for periodontal regeneration: existing evidence and clinical applications |
| title_full | Latest update on the use of recombinant growth factors for periodontal regeneration: existing evidence and clinical applications |
| title_fullStr | Latest update on the use of recombinant growth factors for periodontal regeneration: existing evidence and clinical applications |
| title_full_unstemmed | Latest update on the use of recombinant growth factors for periodontal regeneration: existing evidence and clinical applications |
| title_short | Latest update on the use of recombinant growth factors for periodontal regeneration: existing evidence and clinical applications |
| title_sort | latest update on the use of recombinant growth factors for periodontal regeneration existing evidence and clinical applications |
| url | https://doi.org/10.1177/20406223241302707 |
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