The alteration of neuronal activities of the cuneiform nucleus in non-hypovolemic and hypovolemic hypotensive conditions
Abstract Background: The cuneiform nucleus is located in the center of the circuit that mediates autonomic responses to stress. Hemorrhagic hypotension leads to chemoreceptor anoxia, which consequently results in the reduction of baroreceptor discharge and stimulation of the chemoreceptor. Objecti...
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Thieme Revinter Publicações
2021-01-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021001000871&tlng=en |
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| _version_ | 1849736615607402496 |
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| author | Reza Mohebbati Hassan Abbassian Mohammad Naser Shafei Ali Gorji Sajad Sahab Negah |
| author_facet | Reza Mohebbati Hassan Abbassian Mohammad Naser Shafei Ali Gorji Sajad Sahab Negah |
| author_sort | Reza Mohebbati |
| collection | DOAJ |
| description | Abstract Background: The cuneiform nucleus is located in the center of the circuit that mediates autonomic responses to stress. Hemorrhagic hypotension leads to chemoreceptor anoxia, which consequently results in the reduction of baroreceptor discharge and stimulation of the chemoreceptor. Objective: Using the single-unit recording technique, the neuronal activities of the cuneiform nucleus were investigated in hypotensive states induced by hemorrhage and administration of an anti-hypertensive drug (hydralazine). Methods: Thirty male rats were divided into the control, hemorrhage, and hydralazine groups. The femoral artery was cannulated for the recording of cardiovascular responses, including systolic blood pressure, mean arterial pressure, and heart rate. Hydralazine was administered via tail vein. The single-unit recording was performed from the cuneiform nucleus. Results: The maximal systolic blood pressure and the mean arterial pressure significantly decreased and heart rate significantly increased after the application of hydralazine as well as the following hemorrhage compared to the control group. Hypotension significantly increased the firing rate of the cuneiform nucleus in both the hemorrhage and hydralazine groups compared to the control group. Conclusions: The present data indicate that the cuneiform nucleus activities following hypotension may play a crucial role in blood vessels and vasomotor tone. |
| format | Article |
| id | doaj-art-838063e85645474d8f3be518ccf9fc31 |
| institution | DOAJ |
| issn | 1678-4227 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-838063e85645474d8f3be518ccf9fc312025-08-20T03:07:13ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272021-01-01791087187810.1590/0004-282x-anp-2020-0549The alteration of neuronal activities of the cuneiform nucleus in non-hypovolemic and hypovolemic hypotensive conditionsReza Mohebbatihttps://orcid.org/0000-0002-1645-7094Hassan Abbassianhttps://orcid.org/0000-0001-9878-7670Mohammad Naser Shafeihttps://orcid.org/0000-0001-5148-9895Ali Gorjihttps://orcid.org/0000-0002-4557-3270Sajad Sahab Negahhttps://orcid.org/0000-0002-2242-9794Abstract Background: The cuneiform nucleus is located in the center of the circuit that mediates autonomic responses to stress. Hemorrhagic hypotension leads to chemoreceptor anoxia, which consequently results in the reduction of baroreceptor discharge and stimulation of the chemoreceptor. Objective: Using the single-unit recording technique, the neuronal activities of the cuneiform nucleus were investigated in hypotensive states induced by hemorrhage and administration of an anti-hypertensive drug (hydralazine). Methods: Thirty male rats were divided into the control, hemorrhage, and hydralazine groups. The femoral artery was cannulated for the recording of cardiovascular responses, including systolic blood pressure, mean arterial pressure, and heart rate. Hydralazine was administered via tail vein. The single-unit recording was performed from the cuneiform nucleus. Results: The maximal systolic blood pressure and the mean arterial pressure significantly decreased and heart rate significantly increased after the application of hydralazine as well as the following hemorrhage compared to the control group. Hypotension significantly increased the firing rate of the cuneiform nucleus in both the hemorrhage and hydralazine groups compared to the control group. Conclusions: The present data indicate that the cuneiform nucleus activities following hypotension may play a crucial role in blood vessels and vasomotor tone.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021001000871&tlng=enHemorrhageBlood PressureCardiovascular SystemHydralazineElectrophysiology |
| spellingShingle | Reza Mohebbati Hassan Abbassian Mohammad Naser Shafei Ali Gorji Sajad Sahab Negah The alteration of neuronal activities of the cuneiform nucleus in non-hypovolemic and hypovolemic hypotensive conditions Arquivos de Neuro-Psiquiatria Hemorrhage Blood Pressure Cardiovascular System Hydralazine Electrophysiology |
| title | The alteration of neuronal activities of the cuneiform nucleus in non-hypovolemic and hypovolemic hypotensive conditions |
| title_full | The alteration of neuronal activities of the cuneiform nucleus in non-hypovolemic and hypovolemic hypotensive conditions |
| title_fullStr | The alteration of neuronal activities of the cuneiform nucleus in non-hypovolemic and hypovolemic hypotensive conditions |
| title_full_unstemmed | The alteration of neuronal activities of the cuneiform nucleus in non-hypovolemic and hypovolemic hypotensive conditions |
| title_short | The alteration of neuronal activities of the cuneiform nucleus in non-hypovolemic and hypovolemic hypotensive conditions |
| title_sort | alteration of neuronal activities of the cuneiform nucleus in non hypovolemic and hypovolemic hypotensive conditions |
| topic | Hemorrhage Blood Pressure Cardiovascular System Hydralazine Electrophysiology |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021001000871&tlng=en |
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