Dendrimeric Systems and Their Applications in Ocular Drug Delivery
Ophthalmic drug delivery is one of the most attractive and challenging research area for pharmaceutical scientists and ophthalmologists. Absorption of an ophthalmic drug in conventional dosage forms is seriously limited by physiological conditions. The use of nonionic or ionic biodegradable polymers...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/732340 |
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| _version_ | 1850213955363930112 |
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| author | Burçin Yavuz Sibel Bozdağ Pehlivan Nurşen Ünlü |
| author_facet | Burçin Yavuz Sibel Bozdağ Pehlivan Nurşen Ünlü |
| author_sort | Burçin Yavuz |
| collection | DOAJ |
| description | Ophthalmic drug delivery is one of the most attractive and challenging research area for pharmaceutical scientists and ophthalmologists. Absorption of an ophthalmic drug in conventional dosage forms is seriously limited by physiological conditions. The use of nonionic or ionic biodegradable polymers in aqueous solutions and colloidal dosage forms such as liposomes, nanoparticles, nanocapsules, microspheres, microcapsules, microemulsions, and dendrimers has been studied to overcome the problems mentioned above. Dendrimers are a new class of polymeric materials. The unique nanostructured architecture of dendrimers has been studied to examine their role in delivery of therapeutics and imaging agents. Dendrimers can enhance drug’s water solubility, bioavailability, and biocompatibility and can be applied for different routes of drug administration successfully. Permeability enhancer properties of dendrimers were also reported. The use of dendrimers can also reduce toxicity versus activity and following an appropriate application route they allow the delivery of the drug to the targeted site and provide desired pharmacokinetic parameters. Therefore, dendrimeric drug delivery systems are of interest in ocular drug delivery. In this review, the limitations related to eye’s unique structure, the advantages of dendrimers, and the potential applications of dendrimeric systems to ophthalmology including imaging, drug, peptide, and gene delivery will be discussed. |
| format | Article |
| id | doaj-art-837e7dafca9e49fd9bc023e9a9620eb3 |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-837e7dafca9e49fd9bc023e9a9620eb32025-08-20T02:09:01ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/732340732340Dendrimeric Systems and Their Applications in Ocular Drug DeliveryBurçin Yavuz0Sibel Bozdağ Pehlivan1Nurşen Ünlü2Pharmaceutical Technology Department, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, TurkeyPharmaceutical Technology Department, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, TurkeyPharmaceutical Technology Department, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, TurkeyOphthalmic drug delivery is one of the most attractive and challenging research area for pharmaceutical scientists and ophthalmologists. Absorption of an ophthalmic drug in conventional dosage forms is seriously limited by physiological conditions. The use of nonionic or ionic biodegradable polymers in aqueous solutions and colloidal dosage forms such as liposomes, nanoparticles, nanocapsules, microspheres, microcapsules, microemulsions, and dendrimers has been studied to overcome the problems mentioned above. Dendrimers are a new class of polymeric materials. The unique nanostructured architecture of dendrimers has been studied to examine their role in delivery of therapeutics and imaging agents. Dendrimers can enhance drug’s water solubility, bioavailability, and biocompatibility and can be applied for different routes of drug administration successfully. Permeability enhancer properties of dendrimers were also reported. The use of dendrimers can also reduce toxicity versus activity and following an appropriate application route they allow the delivery of the drug to the targeted site and provide desired pharmacokinetic parameters. Therefore, dendrimeric drug delivery systems are of interest in ocular drug delivery. In this review, the limitations related to eye’s unique structure, the advantages of dendrimers, and the potential applications of dendrimeric systems to ophthalmology including imaging, drug, peptide, and gene delivery will be discussed.http://dx.doi.org/10.1155/2013/732340 |
| spellingShingle | Burçin Yavuz Sibel Bozdağ Pehlivan Nurşen Ünlü Dendrimeric Systems and Their Applications in Ocular Drug Delivery The Scientific World Journal |
| title | Dendrimeric Systems and Their Applications in Ocular Drug Delivery |
| title_full | Dendrimeric Systems and Their Applications in Ocular Drug Delivery |
| title_fullStr | Dendrimeric Systems and Their Applications in Ocular Drug Delivery |
| title_full_unstemmed | Dendrimeric Systems and Their Applications in Ocular Drug Delivery |
| title_short | Dendrimeric Systems and Their Applications in Ocular Drug Delivery |
| title_sort | dendrimeric systems and their applications in ocular drug delivery |
| url | http://dx.doi.org/10.1155/2013/732340 |
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