Antibacterial MXenes: An emerging non-antibiotic paradigm for surface engineering of orthopedic and dental implants
The colonization of planktonic bacteria onto implant surfaces is a serious concern in the medical field due to increasing infection-related mortality and fiscal difficulties worldwide. Various static, dynamic, and active coating techniques were established to tackle implant-associated infections (IA...
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KeAi Communications Co., Ltd.
2025-09-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X25001884 |
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| author | Sathishkumar Gnanasekar Xiaodong He Bruna E. Nagay Kun Xu Xi Rao Shun Duan Selvakumar Murugesan Valentim A.R. Barão En-Tang Kang Liqun Xu |
| author_facet | Sathishkumar Gnanasekar Xiaodong He Bruna E. Nagay Kun Xu Xi Rao Shun Duan Selvakumar Murugesan Valentim A.R. Barão En-Tang Kang Liqun Xu |
| author_sort | Sathishkumar Gnanasekar |
| collection | DOAJ |
| description | The colonization of planktonic bacteria onto implant surfaces is a serious concern in the medical field due to increasing infection-related mortality and fiscal difficulties worldwide. Various static, dynamic, and active coating techniques were established to tackle implant-associated infections (IAIs). However, the existing implant coating methods often confront issues with poor universality for different substrates, adaptability, stability, and the emergence of multi-drug resistance (MDR). The miraculous two-dimensional (2D) MXenes with outstanding multimodal bactericidal effects have been spotted as promising non-antibiotic implant surface coating additives for superior antibiofilm and osseointegration properties. This review systematically assesses the recent progress of antibacterial MXenes and their revolutionary usage to prevent peri-implantitis. We specifically sought to disclose the various forms of MXenes, such as composites, heterojunctions (HJs), and functional biomaterials used in combatting MDR and non-MDR bacterial pathogens by adopting therapeutic ventures such as photothermal therapy (PTT), photodynamic therapy (PDT), chemodynamic therapy (CDT), and sonodynamic therapy (SDT). In addition, we outlined the extension of MXene antibacterial systems for orthopedic and dental implant surface engineering to improve their longevity and safety. A thorough understanding of antibacterial MXenes synthesis, surface modification strategies, and biocompatible functional properties was deliberated to facilitate the construction of innovative coatings. Lastly, some viewpoints on the current limitations and key considerations for the future concept design of MXenes-coated implants were contemplated constructively to promote clinical outcomes. |
| format | Article |
| id | doaj-art-8374c89bb7bc4c1d96fbb70a2c7ec72e |
| institution | DOAJ |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj-art-8374c89bb7bc4c1d96fbb70a2c7ec72e2025-08-20T03:00:25ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-09-015115017610.1016/j.bioactmat.2025.05.002Antibacterial MXenes: An emerging non-antibiotic paradigm for surface engineering of orthopedic and dental implantsSathishkumar Gnanasekar0Xiaodong He1Bruna E. Nagay2Kun Xu3Xi Rao4Shun Duan5Selvakumar Murugesan6Valentim A.R. Barão7En-Tang Kang8Liqun Xu9BRICS Joint Laboratory on Biomedical Materials, School of Materials and Energy, Southwest University, Chongqing, 400715, PR ChinaBRICS Joint Laboratory on Biomedical Materials, School of Materials and Energy, Southwest University, Chongqing, 400715, PR ChinaDepartment of Prosthodontics and Periodontology, Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP), Piracicaba, São Paulo, 13414-903, BrazilBRICS Joint Laboratory on Biomedical Materials, School of Materials and Energy, Southwest University, Chongqing, 400715, PR China; Corresponding author.BRICS Joint Laboratory on Biomedical Materials, School of Materials and Energy, Southwest University, Chongqing, 400715, PR ChinaBeijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, PR ChinaFunctional Biomaterials Laboratory, Department of Metallurgical and Materials Engineering, National Institute of Technology Karnataka, Surathkal, Mangalore, Karnataka, 575025, India; Corresponding author.Department of Prosthodontics and Periodontology, Piracicaba Dental School, Universidade Estadual de Campinas (UNICAMP), Piracicaba, São Paulo, 13414-903, Brazil; Corresponding author.BRICS Joint Laboratory on Biomedical Materials, School of Materials and Energy, Southwest University, Chongqing, 400715, PR China; Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge, 117576, SingaporeBRICS Joint Laboratory on Biomedical Materials, School of Materials and Energy, Southwest University, Chongqing, 400715, PR China; Corresponding author.The colonization of planktonic bacteria onto implant surfaces is a serious concern in the medical field due to increasing infection-related mortality and fiscal difficulties worldwide. Various static, dynamic, and active coating techniques were established to tackle implant-associated infections (IAIs). However, the existing implant coating methods often confront issues with poor universality for different substrates, adaptability, stability, and the emergence of multi-drug resistance (MDR). The miraculous two-dimensional (2D) MXenes with outstanding multimodal bactericidal effects have been spotted as promising non-antibiotic implant surface coating additives for superior antibiofilm and osseointegration properties. This review systematically assesses the recent progress of antibacterial MXenes and their revolutionary usage to prevent peri-implantitis. We specifically sought to disclose the various forms of MXenes, such as composites, heterojunctions (HJs), and functional biomaterials used in combatting MDR and non-MDR bacterial pathogens by adopting therapeutic ventures such as photothermal therapy (PTT), photodynamic therapy (PDT), chemodynamic therapy (CDT), and sonodynamic therapy (SDT). In addition, we outlined the extension of MXene antibacterial systems for orthopedic and dental implant surface engineering to improve their longevity and safety. A thorough understanding of antibacterial MXenes synthesis, surface modification strategies, and biocompatible functional properties was deliberated to facilitate the construction of innovative coatings. Lastly, some viewpoints on the current limitations and key considerations for the future concept design of MXenes-coated implants were contemplated constructively to promote clinical outcomes.http://www.sciencedirect.com/science/article/pii/S2452199X25001884MXenesCoatingsAntibacterialPeri-implantitisSurface modificationOsseointegration |
| spellingShingle | Sathishkumar Gnanasekar Xiaodong He Bruna E. Nagay Kun Xu Xi Rao Shun Duan Selvakumar Murugesan Valentim A.R. Barão En-Tang Kang Liqun Xu Antibacterial MXenes: An emerging non-antibiotic paradigm for surface engineering of orthopedic and dental implants Bioactive Materials MXenes Coatings Antibacterial Peri-implantitis Surface modification Osseointegration |
| title | Antibacterial MXenes: An emerging non-antibiotic paradigm for surface engineering of orthopedic and dental implants |
| title_full | Antibacterial MXenes: An emerging non-antibiotic paradigm for surface engineering of orthopedic and dental implants |
| title_fullStr | Antibacterial MXenes: An emerging non-antibiotic paradigm for surface engineering of orthopedic and dental implants |
| title_full_unstemmed | Antibacterial MXenes: An emerging non-antibiotic paradigm for surface engineering of orthopedic and dental implants |
| title_short | Antibacterial MXenes: An emerging non-antibiotic paradigm for surface engineering of orthopedic and dental implants |
| title_sort | antibacterial mxenes an emerging non antibiotic paradigm for surface engineering of orthopedic and dental implants |
| topic | MXenes Coatings Antibacterial Peri-implantitis Surface modification Osseointegration |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X25001884 |
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