Vascular Smooth Muscle Cell Development and Cardiovascular Malformations
Abstract. Vascular smooth muscle cells (VSMCs) have diverse biological functions that include maintaining the vascular structure and recruiting progenitors to form the embryonic vascular system. Accumulating evidence suggests that the VSMCs are not just derived from the mesoderm, as previously thoug...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2021-12-01
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| Series: | Cardiology Discovery |
| Online Access: | http://journals.lww.com/10.1097/CD9.0000000000000035 |
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| _version_ | 1850217912669831168 |
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| author | Lihua Qi Wei Kong Yi Fu Xiaoxia Fu Tianyu Xu |
| author_facet | Lihua Qi Wei Kong Yi Fu Xiaoxia Fu Tianyu Xu |
| author_sort | Lihua Qi |
| collection | DOAJ |
| description | Abstract. Vascular smooth muscle cells (VSMCs) have diverse biological functions that include maintaining the vascular structure and recruiting progenitors to form the embryonic vascular system. Accumulating evidence suggests that the VSMCs are not just derived from the mesoderm, as previously thought, but have diverse developmental origins. Lineage tracing analysis indicates that VSMCs have at least 7 different origins, thereby giving it the characteristic of a mosaic tissue. The crucial role of the diverse origins of the VSMCs has been recognized in relation to blood vessel function and diseases such as arteriosclerosis. The VSMC distribution in cardiovascular development and whether and how their heterogeneous origins contribute to the overall cardiovascular development continue to be topics of research. Here, we review the current state of research, mainly focusing on the role of VSMCs in cardiovascular development. We emphasize the following biological pathways: (1) normal course of development of VSMCs and their diverse origins in relation to cardiovascular development, (2) signaling regulation of progenitor cell development and differentiation into VSMCs, and (3) abnormal development of vascular smooth muscle and the associated cardiovascular malformations. |
| format | Article |
| id | doaj-art-8374c31a32bf42f28bd4bd480d48025d |
| institution | OA Journals |
| issn | 2096-952X 2693-8499 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Cardiology Discovery |
| spelling | doaj-art-8374c31a32bf42f28bd4bd480d48025d2025-08-20T02:07:57ZengWolters Kluwer Health/LWWCardiology Discovery2096-952X2693-84992021-12-011425926810.1097/CD9.0000000000000035202112000-00006Vascular Smooth Muscle Cell Development and Cardiovascular MalformationsLihua QiWei KongYi FuXiaoxia FuTianyu XuAbstract. Vascular smooth muscle cells (VSMCs) have diverse biological functions that include maintaining the vascular structure and recruiting progenitors to form the embryonic vascular system. Accumulating evidence suggests that the VSMCs are not just derived from the mesoderm, as previously thought, but have diverse developmental origins. Lineage tracing analysis indicates that VSMCs have at least 7 different origins, thereby giving it the characteristic of a mosaic tissue. The crucial role of the diverse origins of the VSMCs has been recognized in relation to blood vessel function and diseases such as arteriosclerosis. The VSMC distribution in cardiovascular development and whether and how their heterogeneous origins contribute to the overall cardiovascular development continue to be topics of research. Here, we review the current state of research, mainly focusing on the role of VSMCs in cardiovascular development. We emphasize the following biological pathways: (1) normal course of development of VSMCs and their diverse origins in relation to cardiovascular development, (2) signaling regulation of progenitor cell development and differentiation into VSMCs, and (3) abnormal development of vascular smooth muscle and the associated cardiovascular malformations.http://journals.lww.com/10.1097/CD9.0000000000000035 |
| spellingShingle | Lihua Qi Wei Kong Yi Fu Xiaoxia Fu Tianyu Xu Vascular Smooth Muscle Cell Development and Cardiovascular Malformations Cardiology Discovery |
| title | Vascular Smooth Muscle Cell Development and Cardiovascular Malformations |
| title_full | Vascular Smooth Muscle Cell Development and Cardiovascular Malformations |
| title_fullStr | Vascular Smooth Muscle Cell Development and Cardiovascular Malformations |
| title_full_unstemmed | Vascular Smooth Muscle Cell Development and Cardiovascular Malformations |
| title_short | Vascular Smooth Muscle Cell Development and Cardiovascular Malformations |
| title_sort | vascular smooth muscle cell development and cardiovascular malformations |
| url | http://journals.lww.com/10.1097/CD9.0000000000000035 |
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