Pleuropulmonary blastoma in a 3-year-old child with persistent fever: a case report
Pleuropulmonary blastoma (PPB) is a rare and highly aggressive malignant mesenchymal tumor, representing the most common malignant lung tumor in children. It is often misdiagnosed or underdiagnosed due to its clinical presentation, which mimics acute respiratory infections. Additionally, imaging man...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1534277/full |
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| _version_ | 1850084929053917184 |
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| author | Ruiqi Yue Guixia Ma Li Mao Qian Ni |
| author_facet | Ruiqi Yue Guixia Ma Li Mao Qian Ni |
| author_sort | Ruiqi Yue |
| collection | DOAJ |
| description | Pleuropulmonary blastoma (PPB) is a rare and highly aggressive malignant mesenchymal tumor, representing the most common malignant lung tumor in children. It is often misdiagnosed or underdiagnosed due to its clinical presentation, which mimics acute respiratory infections. Additionally, imaging manifestations are frequently indistinguishable from congenital respiratory malformations or severe lung infections. The tumor has high rates of recurrence and metastasis and has a poor prognosis. Currently, the internationally recommended treatment for PPB is a combination of surgery, chemotherapy, and radiotherapy. This article discusses the diagnosis and treatment of a 3-year-old girl with PPB combined with severe pneumonia. |
| format | Article |
| id | doaj-art-8369eed1ca45404696e822bedb889f03 |
| institution | DOAJ |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-8369eed1ca45404696e822bedb889f032025-08-20T02:43:50ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-02-011310.3389/fped.2025.15342771534277Pleuropulmonary blastoma in a 3-year-old child with persistent fever: a case reportRuiqi Yue0Guixia Ma1Li Mao2Qian Ni3The Second Clinical Medical College of Lanzhou University, Lanzhou University, Lanzhou, ChinaPediatric Respiratory Medicine, Lanzhou University Second Hospital, Lanzhou, ChinaPediatric Respiratory Medicine, Lanzhou University Second Hospital, Lanzhou, ChinaPediatric Respiratory Medicine, Lanzhou University Second Hospital, Lanzhou, ChinaPleuropulmonary blastoma (PPB) is a rare and highly aggressive malignant mesenchymal tumor, representing the most common malignant lung tumor in children. It is often misdiagnosed or underdiagnosed due to its clinical presentation, which mimics acute respiratory infections. Additionally, imaging manifestations are frequently indistinguishable from congenital respiratory malformations or severe lung infections. The tumor has high rates of recurrence and metastasis and has a poor prognosis. Currently, the internationally recommended treatment for PPB is a combination of surgery, chemotherapy, and radiotherapy. This article discusses the diagnosis and treatment of a 3-year-old girl with PPB combined with severe pneumonia.https://www.frontiersin.org/articles/10.3389/fped.2025.1534277/fullpleuropulmonary blastomapediatric lung tumoracute respiratory infectionsmisdiagnosisDICER1 mutation |
| spellingShingle | Ruiqi Yue Guixia Ma Li Mao Qian Ni Pleuropulmonary blastoma in a 3-year-old child with persistent fever: a case report Frontiers in Pediatrics pleuropulmonary blastoma pediatric lung tumor acute respiratory infections misdiagnosis DICER1 mutation |
| title | Pleuropulmonary blastoma in a 3-year-old child with persistent fever: a case report |
| title_full | Pleuropulmonary blastoma in a 3-year-old child with persistent fever: a case report |
| title_fullStr | Pleuropulmonary blastoma in a 3-year-old child with persistent fever: a case report |
| title_full_unstemmed | Pleuropulmonary blastoma in a 3-year-old child with persistent fever: a case report |
| title_short | Pleuropulmonary blastoma in a 3-year-old child with persistent fever: a case report |
| title_sort | pleuropulmonary blastoma in a 3 year old child with persistent fever a case report |
| topic | pleuropulmonary blastoma pediatric lung tumor acute respiratory infections misdiagnosis DICER1 mutation |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1534277/full |
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