Non-Coding RNAs in Asthma: Regulators of Eosinophil Biology and Airway Inflammation
Asthma is a complex and heterogeneous disease characterized by chronic airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction. Despite extensive research, its underlying molecular mechanisms remain incompletely understood. Among the key immune cells involved, eosinoph...
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| Language: | English |
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MDPI AG
2025-07-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/15/14/1750 |
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| author | Eglė Vasylė Andrius Januškevičius Kęstutis Malakauskas |
| author_facet | Eglė Vasylė Andrius Januškevičius Kęstutis Malakauskas |
| author_sort | Eglė Vasylė |
| collection | DOAJ |
| description | Asthma is a complex and heterogeneous disease characterized by chronic airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction. Despite extensive research, its underlying molecular mechanisms remain incompletely understood. Among the key immune cells involved, eosinophils play a central role in asthma pathophysiology through their contributions to Type 2 inflammation, tissue remodeling, and immune regulation. Recent studies have shown that non-coding RNAs (ncRNAs) play a crucial role in regulating eosinophil biology and contribute to the molecular mechanisms underlying asthma progression. This review consolidates the current understanding of ncRNAs in the development of eosinophils, their involvement in asthma pathogenesis, and the mechanisms underlying this process. |
| format | Article |
| id | doaj-art-8365aa2693be4abab1cf615fa91cb977 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-8365aa2693be4abab1cf615fa91cb9772025-08-20T03:32:31ZengMDPI AGDiagnostics2075-44182025-07-011514175010.3390/diagnostics15141750Non-Coding RNAs in Asthma: Regulators of Eosinophil Biology and Airway InflammationEglė Vasylė0Andrius Januškevičius1Kęstutis Malakauskas2Laboratory of Pulmonology, Department of Pulmonology, Lithuanian University of Health Sciences, 44307 Kaunas, LithuaniaLaboratory of Pulmonology, Department of Pulmonology, Lithuanian University of Health Sciences, 44307 Kaunas, LithuaniaLaboratory of Pulmonology, Department of Pulmonology, Lithuanian University of Health Sciences, 44307 Kaunas, LithuaniaAsthma is a complex and heterogeneous disease characterized by chronic airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction. Despite extensive research, its underlying molecular mechanisms remain incompletely understood. Among the key immune cells involved, eosinophils play a central role in asthma pathophysiology through their contributions to Type 2 inflammation, tissue remodeling, and immune regulation. Recent studies have shown that non-coding RNAs (ncRNAs) play a crucial role in regulating eosinophil biology and contribute to the molecular mechanisms underlying asthma progression. This review consolidates the current understanding of ncRNAs in the development of eosinophils, their involvement in asthma pathogenesis, and the mechanisms underlying this process.https://www.mdpi.com/2075-4418/15/14/1750asthmaeosinophilairway inflammationncRNAlncRNAcircRNA |
| spellingShingle | Eglė Vasylė Andrius Januškevičius Kęstutis Malakauskas Non-Coding RNAs in Asthma: Regulators of Eosinophil Biology and Airway Inflammation Diagnostics asthma eosinophil airway inflammation ncRNA lncRNA circRNA |
| title | Non-Coding RNAs in Asthma: Regulators of Eosinophil Biology and Airway Inflammation |
| title_full | Non-Coding RNAs in Asthma: Regulators of Eosinophil Biology and Airway Inflammation |
| title_fullStr | Non-Coding RNAs in Asthma: Regulators of Eosinophil Biology and Airway Inflammation |
| title_full_unstemmed | Non-Coding RNAs in Asthma: Regulators of Eosinophil Biology and Airway Inflammation |
| title_short | Non-Coding RNAs in Asthma: Regulators of Eosinophil Biology and Airway Inflammation |
| title_sort | non coding rnas in asthma regulators of eosinophil biology and airway inflammation |
| topic | asthma eosinophil airway inflammation ncRNA lncRNA circRNA |
| url | https://www.mdpi.com/2075-4418/15/14/1750 |
| work_keys_str_mv | AT eglevasyle noncodingrnasinasthmaregulatorsofeosinophilbiologyandairwayinflammation AT andriusjanuskevicius noncodingrnasinasthmaregulatorsofeosinophilbiologyandairwayinflammation AT kestutismalakauskas noncodingrnasinasthmaregulatorsofeosinophilbiologyandairwayinflammation |