Association between inflammatory proteins and rotator cuff tears: a bidirectional Mendelian randomization study
Abstract Previous research suggests a link between inflammatory proteins and rotator cuff tears, but the specific protein remains unclear. This two-sample Mendelian randomization (MR) study used genetic variants from a genome-wide association study (GWAS) of 14,824 primarily European participants. W...
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-12785-y |
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| author | Yao Wang Binbin Xu Chenhao Ma Donghai Huang Li Zhou |
| author_facet | Yao Wang Binbin Xu Chenhao Ma Donghai Huang Li Zhou |
| author_sort | Yao Wang |
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| description | Abstract Previous research suggests a link between inflammatory proteins and rotator cuff tears, but the specific protein remains unclear. This two-sample Mendelian randomization (MR) study used genetic variants from a genome-wide association study (GWAS) of 14,824 primarily European participants. We analyzed 91 circulating inflammatory proteins using inverse variance weighting (IVW) and validated results with MR-Egger, the weighted median approach, and sensitivity tests. MR analysis identified three inflammatory proteins with significant associations in the IVW analysis: Interleukin-20 (IL-20) levels (OR = 1.225, 95% CI = 1.036 − 1.450, P = 0.044), Leukemia inhibitory factor levels (LIF) (OR = 1.380, 95% CI = 1.008 − 1.889, P = 0.044), and Signaling lymphocytic activation molecule (SLAM) (OR = 1.183, 95% CI = 1.059 − 1.321, P = 0.015). Elevated IL-20, LIF and SLAM increased the risk of rotator cuff tears. This MR study reveals a potential association between IL-20, LIF and SLAM and the risk of rotator cuff tears, providing insights into their pathogenesis and potential therapeutic targets. |
| format | Article |
| id | doaj-art-8360e69caafd474e96943ba015ed12f8 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-8360e69caafd474e96943ba015ed12f82025-08-20T03:05:21ZengNature PortfolioScientific Reports2045-23222025-07-0115111210.1038/s41598-025-12785-yAssociation between inflammatory proteins and rotator cuff tears: a bidirectional Mendelian randomization studyYao Wang0Binbin Xu1Chenhao Ma2Donghai Huang3Li Zhou4Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineZhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineZhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineZhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese MedicineDepartment of Orthopaedic, Guangdong Provincial Hospital of Chinese Medicine, Hainan Hospital, Guangzhou University of Chinese MedicineAbstract Previous research suggests a link between inflammatory proteins and rotator cuff tears, but the specific protein remains unclear. This two-sample Mendelian randomization (MR) study used genetic variants from a genome-wide association study (GWAS) of 14,824 primarily European participants. We analyzed 91 circulating inflammatory proteins using inverse variance weighting (IVW) and validated results with MR-Egger, the weighted median approach, and sensitivity tests. MR analysis identified three inflammatory proteins with significant associations in the IVW analysis: Interleukin-20 (IL-20) levels (OR = 1.225, 95% CI = 1.036 − 1.450, P = 0.044), Leukemia inhibitory factor levels (LIF) (OR = 1.380, 95% CI = 1.008 − 1.889, P = 0.044), and Signaling lymphocytic activation molecule (SLAM) (OR = 1.183, 95% CI = 1.059 − 1.321, P = 0.015). Elevated IL-20, LIF and SLAM increased the risk of rotator cuff tears. This MR study reveals a potential association between IL-20, LIF and SLAM and the risk of rotator cuff tears, providing insights into their pathogenesis and potential therapeutic targets.https://doi.org/10.1038/s41598-025-12785-yRotator cuff tearsInflammatory proteinsMendelian randomizationInterleukin-20Leukemia inhibitory factorSignaling lymphocytic activation molecule |
| spellingShingle | Yao Wang Binbin Xu Chenhao Ma Donghai Huang Li Zhou Association between inflammatory proteins and rotator cuff tears: a bidirectional Mendelian randomization study Scientific Reports Rotator cuff tears Inflammatory proteins Mendelian randomization Interleukin-20 Leukemia inhibitory factor Signaling lymphocytic activation molecule |
| title | Association between inflammatory proteins and rotator cuff tears: a bidirectional Mendelian randomization study |
| title_full | Association between inflammatory proteins and rotator cuff tears: a bidirectional Mendelian randomization study |
| title_fullStr | Association between inflammatory proteins and rotator cuff tears: a bidirectional Mendelian randomization study |
| title_full_unstemmed | Association between inflammatory proteins and rotator cuff tears: a bidirectional Mendelian randomization study |
| title_short | Association between inflammatory proteins and rotator cuff tears: a bidirectional Mendelian randomization study |
| title_sort | association between inflammatory proteins and rotator cuff tears a bidirectional mendelian randomization study |
| topic | Rotator cuff tears Inflammatory proteins Mendelian randomization Interleukin-20 Leukemia inhibitory factor Signaling lymphocytic activation molecule |
| url | https://doi.org/10.1038/s41598-025-12785-y |
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