Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche’s Endocannabinoid System Projects
The endocannabinoid system (ECS) is a critical regulatory network composed of endogenous cannabinoids (eCBs), their synthesizing and degrading enzymes, and associated receptors. It is integral to maintaining homeostasis and orchestrating key functions within the central nervous and immune systems. G...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | deu |
| Published: |
Swiss Chemical Society
2024-08-01
|
| Series: | CHIMIA |
| Subjects: | |
| Online Access: | https://www.chimia.ch/chimia/article/view/7352 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850283826359566336 |
|---|---|
| author | Johannes Aebi Kenneth Atz Simon M. Ametamey Jörg Benz Julie Blaising Stefania Butini Giuseppe Campiani Erick M. Carreira Ludovic Collin Eva de Lago Thais Gazzi Jürg Gertsch Luca Gobbi Wolfgang Guba Javier Fernández-Ruiz Jürgen Fingerle Achi Haider Yingfang He Laura H. Heitman Michael Honer Daniel Hunziker Bernd Kuhn Mauro Maccarrone Hans Peter Märki Rainer E. Martin Peter Mohr Linjing Mu Marc Nazaré David F. Nippa Sergio Oddi Fionn O’Hara Pal Pacher Julian Romero Stephan Röver Arne C. Rufer Roger Schibli Gisbert Schneider Antonia F. Stepan David A. Sykes Christoph Ullmer Mario van der Stelt Dmitry B. Veprintsev Matthias B. Wittwer Uwe Grether |
| author_facet | Johannes Aebi Kenneth Atz Simon M. Ametamey Jörg Benz Julie Blaising Stefania Butini Giuseppe Campiani Erick M. Carreira Ludovic Collin Eva de Lago Thais Gazzi Jürg Gertsch Luca Gobbi Wolfgang Guba Javier Fernández-Ruiz Jürgen Fingerle Achi Haider Yingfang He Laura H. Heitman Michael Honer Daniel Hunziker Bernd Kuhn Mauro Maccarrone Hans Peter Märki Rainer E. Martin Peter Mohr Linjing Mu Marc Nazaré David F. Nippa Sergio Oddi Fionn O’Hara Pal Pacher Julian Romero Stephan Röver Arne C. Rufer Roger Schibli Gisbert Schneider Antonia F. Stepan David A. Sykes Christoph Ullmer Mario van der Stelt Dmitry B. Veprintsev Matthias B. Wittwer Uwe Grether |
| author_sort | Johannes Aebi |
| collection | DOAJ |
| description | The endocannabinoid system (ECS) is a critical regulatory network composed of endogenous cannabinoids (eCBs), their synthesizing and degrading enzymes, and associated receptors. It is integral to maintaining homeostasis and orchestrating key functions within the central nervous and immune systems. Given its therapeutic significance, we have launched a series of drug discovery endeavors aimed at ECS targets, including peroxisome proliferator-activated receptors (PPARs), cannabinoid receptors types 1 (CB1R) and 2 (CB2R), and monoacylglycerol lipase (MAGL), addressing a wide array of medical needs. The pursuit of new therapeutic agents has been enhanced by the creation of specialized labeled chemical probes, which aid in target localization, mechanistic studies, assay development, and the establishment of biomarkers for target engagement. By fusing medicinal chemistry with chemical biology in a comprehensive, translational end-to-end drug discovery strategy, we have expedited the development of novel therapeutics. Additionally, this strategy promises to foster highly productive partnerships between industry and academia, as will be illustrated through various examples.
|
| format | Article |
| id | doaj-art-835ccb882108406e9af1efa1aef4d74d |
| institution | OA Journals |
| issn | 0009-4293 2673-2424 |
| language | deu |
| publishDate | 2024-08-01 |
| publisher | Swiss Chemical Society |
| record_format | Article |
| series | CHIMIA |
| spelling | doaj-art-835ccb882108406e9af1efa1aef4d74d2025-08-20T01:47:42ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24242024-08-01787-810.2533/chimia.2024.499Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche’s Endocannabinoid System ProjectsJohannes Aebi0Kenneth Atz1Simon M. Ametamey2Jörg Benz3Julie Blaising4Stefania Butini5Giuseppe Campiani6Erick M. Carreira7Ludovic Collin8Eva de Lago9Thais Gazzi10Jürg Gertsch11Luca Gobbi12Wolfgang Guba13Javier Fernández-Ruiz14Jürgen Fingerle15Achi Haider16Yingfang He17Laura H. Heitman18Michael Honer19Daniel Hunziker20Bernd Kuhn21Mauro Maccarrone22Hans Peter Märki23Rainer E. Martin24Peter Mohr25Linjing Mu26Marc Nazaré27David F. Nippa28Sergio Oddi29Fionn O’Hara30Pal Pacher31Julian Romero32Stephan Röver33Arne C. Rufer34Roger Schibli35Gisbert Schneider36Antonia F. Stepan37David A. Sykes38Christoph Ullmer39Mario van der Stelt40Dmitry B. Veprintsev41Matthias B. Wittwer42Uwe Grether43https://orcid.org/0000-0002-3164-9270Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandCenter for Radiopharmaceutical Sciences ETH, PSI and USZ, Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, SwitzerlandPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, ItalyDepartment of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, ItalyLaboratorium für Organische Chemie, Eidgenössische Technische Hochschule Zurich, Vladimir-Prelog-Weg 3, 8093 Zurich, SwitzerlandPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandInstituto Universitario de Investigación en Neuroquímica, Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, SpainPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandInstitute of Biochemistry and Molecular Medicine, University of Bern, 3012 Bern, SwitzerlandPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandInstituto Universitario de Investigación en Neuroquímica, Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad Complutense, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, SpainPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandCenter for Radiopharmaceutical Sciences ETH, PSI and USZ, Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, SwitzerlandDivision of Drug Discovery and Safety, Leiden University; Oncode Institute, Leiden, NetherlandsPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandDepartment of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy; European Center for Brain Research, Santa Lucia Foundation, 00128 Rome, ItalyPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandCenter for Radiopharmaceutical Sciences ETH, PSI and USZ, Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, SwitzerlandLeibniz-Forschungsinstitut für Molekulare Pharmakologie FMP, Campus Berlin-Buch, 13125 Berlin, GermanyPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandFaculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy; European, Center for Brain Research (CERC)/Santa Lucia Foundation, 00179 Rome, ItalyPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandNational Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20852, United States of AmericaFaculty of Experimental Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcón, 28223, Madrid, SpainPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandCenter for Radiopharmaceutical Sciences ETH, PSI and USZ, Institute of Pharmaceutical Sciences, ETH Zurich, Vladimir-Prelog-Weg 4, 8093 Zurich, SwitzerlandETH Zurich, Department of Chemistry and Applied Biosciences, Vladimir-Prelog-Weg 4, 8093 Zurich, SwitzerlandPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandFaculty of Medicine & Health Sciences, University of Nottingham, Nottingham NG7 2UH, England; United Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands, EnglandPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandDepartment of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, NetherlandsFaculty of Medicine & Health Sciences, University of Nottingham, Nottingham NG7 2UH, England; United Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham and University of Nottingham, Midlands, EnglandPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, SwitzerlandPharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH-4070 BaselThe endocannabinoid system (ECS) is a critical regulatory network composed of endogenous cannabinoids (eCBs), their synthesizing and degrading enzymes, and associated receptors. It is integral to maintaining homeostasis and orchestrating key functions within the central nervous and immune systems. Given its therapeutic significance, we have launched a series of drug discovery endeavors aimed at ECS targets, including peroxisome proliferator-activated receptors (PPARs), cannabinoid receptors types 1 (CB1R) and 2 (CB2R), and monoacylglycerol lipase (MAGL), addressing a wide array of medical needs. The pursuit of new therapeutic agents has been enhanced by the creation of specialized labeled chemical probes, which aid in target localization, mechanistic studies, assay development, and the establishment of biomarkers for target engagement. By fusing medicinal chemistry with chemical biology in a comprehensive, translational end-to-end drug discovery strategy, we have expedited the development of novel therapeutics. Additionally, this strategy promises to foster highly productive partnerships between industry and academia, as will be illustrated through various examples. https://www.chimia.ch/chimia/article/view/7352Academia-industry collaborationCB1RCB2REndocannabinoid systemLabeled chemical probeMAGL |
| spellingShingle | Johannes Aebi Kenneth Atz Simon M. Ametamey Jörg Benz Julie Blaising Stefania Butini Giuseppe Campiani Erick M. Carreira Ludovic Collin Eva de Lago Thais Gazzi Jürg Gertsch Luca Gobbi Wolfgang Guba Javier Fernández-Ruiz Jürgen Fingerle Achi Haider Yingfang He Laura H. Heitman Michael Honer Daniel Hunziker Bernd Kuhn Mauro Maccarrone Hans Peter Märki Rainer E. Martin Peter Mohr Linjing Mu Marc Nazaré David F. Nippa Sergio Oddi Fionn O’Hara Pal Pacher Julian Romero Stephan Röver Arne C. Rufer Roger Schibli Gisbert Schneider Antonia F. Stepan David A. Sykes Christoph Ullmer Mario van der Stelt Dmitry B. Veprintsev Matthias B. Wittwer Uwe Grether Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche’s Endocannabinoid System Projects CHIMIA Academia-industry collaboration CB1R CB2R Endocannabinoid system Labeled chemical probe MAGL |
| title | Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche’s Endocannabinoid System Projects |
| title_full | Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche’s Endocannabinoid System Projects |
| title_fullStr | Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche’s Endocannabinoid System Projects |
| title_full_unstemmed | Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche’s Endocannabinoid System Projects |
| title_short | Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche’s Endocannabinoid System Projects |
| title_sort | enhancing drug discovery and development through the integration of medicinal chemistry chemical biology and academia industry partnerships insights from roche s endocannabinoid system projects |
| topic | Academia-industry collaboration CB1R CB2R Endocannabinoid system Labeled chemical probe MAGL |
| url | https://www.chimia.ch/chimia/article/view/7352 |
| work_keys_str_mv | AT johannesaebi enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT kennethatz enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT simonmametamey enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT jorgbenz enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT julieblaising enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT stefaniabutini enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT giuseppecampiani enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT erickmcarreira enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT ludoviccollin enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT evadelago enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT thaisgazzi enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT jurggertsch enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT lucagobbi enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT wolfgangguba enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT javierfernandezruiz enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT jurgenfingerle enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT achihaider enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT yingfanghe enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT laurahheitman enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT michaelhoner enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT danielhunziker enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT berndkuhn enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT mauromaccarrone enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT hanspetermarki enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT raineremartin enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT petermohr enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT linjingmu enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT marcnazare enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT davidfnippa enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT sergiooddi enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT fionnohara enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT palpacher enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT julianromero enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT stephanrover enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT arnecrufer enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT rogerschibli enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT gisbertschneider enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT antoniafstepan enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT davidasykes enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT christophullmer enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT mariovanderstelt enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT dmitrybveprintsev enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT matthiasbwittwer enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects AT uwegrether enhancingdrugdiscoveryanddevelopmentthroughtheintegrationofmedicinalchemistrychemicalbiologyandacademiaindustrypartnershipsinsightsfromrochesendocannabinoidsystemprojects |