Impact of R-loops on oncogene-induced replication stress in cancer cells
Replication stress is an alteration in the progression of replication forks caused by a variety of events of endogenous or exogenous origin. In precancerous lesions, this stress is exacerbated by the deregulation of oncogenic pathways, which notably disrupts the coordination between replication and...
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| Format: | Article |
| Language: | English |
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Académie des sciences
2023-09-01
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| Series: | Comptes Rendus Biologies |
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| Online Access: | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.123/ |
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| author | Heuzé, Jonathan Lin, Yea-Lih Lengronne, Armelle Poli, Jérôme Pasero, Philippe |
| author_facet | Heuzé, Jonathan Lin, Yea-Lih Lengronne, Armelle Poli, Jérôme Pasero, Philippe |
| author_sort | Heuzé, Jonathan |
| collection | DOAJ |
| description | Replication stress is an alteration in the progression of replication forks caused by a variety of events of endogenous or exogenous origin. In precancerous lesions, this stress is exacerbated by the deregulation of oncogenic pathways, which notably disrupts the coordination between replication and transcription, and leads to genetic instability and cancer development. It is now well established that transcription can interfere with genome replication in different ways, such as head-on collisions between polymerases, accumulation of positive DNA supercoils or formation of R-loops. These structures form during transcription when nascent RNA reanneals with DNA behind the RNA polymerase, forming a stable DNA:RNA hybrid. In this review, we discuss how these different cotranscriptional processes disrupt the progression of replication forks and how they contribute to genetic instability in cancer cells. |
| format | Article |
| id | doaj-art-8359eb89426e41b1b11a209efdcb1d20 |
| institution | Kabale University |
| issn | 1768-3238 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus Biologies |
| spelling | doaj-art-8359eb89426e41b1b11a209efdcb1d202025-02-07T10:37:08ZengAcadémie des sciencesComptes Rendus Biologies1768-32382023-09-01346G29510510.5802/crbiol.12310.5802/crbiol.123Impact of R-loops on oncogene-induced replication stress in cancer cellsHeuzé, Jonathan0https://orcid.org/0009-0008-2870-521XLin, Yea-Lih1https://orcid.org/0000-0003-4063-0771Lengronne, Armelle2https://orcid.org/0000-0002-3140-7968Poli, Jérôme3https://orcid.org/0000-0001-8091-5507Pasero, Philippe4https://orcid.org/0000-0001-5891-0822Institut de Génétique Humaine, CNRS UMR 9002, Université de Montpellier, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, FranceInstitut de Génétique Humaine, CNRS UMR 9002, Université de Montpellier, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, FranceInstitut de Génétique Humaine, CNRS UMR 9002, Université de Montpellier, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, FranceInstitut de Génétique Humaine, CNRS UMR 9002, Université de Montpellier, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, FranceInstitut de Génétique Humaine, CNRS UMR 9002, Université de Montpellier, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, FranceReplication stress is an alteration in the progression of replication forks caused by a variety of events of endogenous or exogenous origin. In precancerous lesions, this stress is exacerbated by the deregulation of oncogenic pathways, which notably disrupts the coordination between replication and transcription, and leads to genetic instability and cancer development. It is now well established that transcription can interfere with genome replication in different ways, such as head-on collisions between polymerases, accumulation of positive DNA supercoils or formation of R-loops. These structures form during transcription when nascent RNA reanneals with DNA behind the RNA polymerase, forming a stable DNA:RNA hybrid. In this review, we discuss how these different cotranscriptional processes disrupt the progression of replication forks and how they contribute to genetic instability in cancer cells.https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.123/Replication stressTranscription–replication conflictsR-loopsGenomic instabilityOncogenesCancer |
| spellingShingle | Heuzé, Jonathan Lin, Yea-Lih Lengronne, Armelle Poli, Jérôme Pasero, Philippe Impact of R-loops on oncogene-induced replication stress in cancer cells Comptes Rendus Biologies Replication stress Transcription–replication conflicts R-loops Genomic instability Oncogenes Cancer |
| title | Impact of R-loops on oncogene-induced replication stress in cancer cells |
| title_full | Impact of R-loops on oncogene-induced replication stress in cancer cells |
| title_fullStr | Impact of R-loops on oncogene-induced replication stress in cancer cells |
| title_full_unstemmed | Impact of R-loops on oncogene-induced replication stress in cancer cells |
| title_short | Impact of R-loops on oncogene-induced replication stress in cancer cells |
| title_sort | impact of r loops on oncogene induced replication stress in cancer cells |
| topic | Replication stress Transcription–replication conflicts R-loops Genomic instability Oncogenes Cancer |
| url | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.123/ |
| work_keys_str_mv | AT heuzejonathan impactofrloopsononcogeneinducedreplicationstressincancercells AT linyealih impactofrloopsononcogeneinducedreplicationstressincancercells AT lengronnearmelle impactofrloopsononcogeneinducedreplicationstressincancercells AT polijerome impactofrloopsononcogeneinducedreplicationstressincancercells AT paserophilippe impactofrloopsononcogeneinducedreplicationstressincancercells |