Importance of LINC00852/miR-145-5p in breast cancer: a bioinformatics and experimental study
Abstract Purpose We aimed to examine the importance of an lncRNA, namely LINC00852, in the pathogenesis of breast cancer. Materials and methods In the current study, we used several online tools to examine the importance of LINC00852 in breast cancer. Then, we examined these findings in 50 pairs of...
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| Format: | Article |
| Language: | English |
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Springer
2024-11-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-024-01553-5 |
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| author | Abbas Shakoori Asghar Hosseinzadeh Nahid Nafisi Ramesh Omranipour Leyla Sahebi Nazanin Hosseinkhan Mohsen Ahmadi Soudeh Ghafouri-Fard Maryam Abtin |
| author_facet | Abbas Shakoori Asghar Hosseinzadeh Nahid Nafisi Ramesh Omranipour Leyla Sahebi Nazanin Hosseinkhan Mohsen Ahmadi Soudeh Ghafouri-Fard Maryam Abtin |
| author_sort | Abbas Shakoori |
| collection | DOAJ |
| description | Abstract Purpose We aimed to examine the importance of an lncRNA, namely LINC00852, in the pathogenesis of breast cancer. Materials and methods In the current study, we used several online tools to examine the importance of LINC00852 in breast cancer. Then, we examined these findings in 50 pairs of breast cancer tissues and adjacent non-cancerous ones. We also re-evaluated the data of miR-145-5p signature from our recent study. Results While in silico tools revealed down-regulation of LINC00852 in breast cancer samples, expression assays showed significant up-regulation of this lncRNAs in breast cancer samples compared with matching control samples from Iranian patients. miR-145-5p was under-expressed in breast cancer samples compared with non-cancerous samples. LINC00852 could separate breast cancer tissues from adjacent non-malignant tissues with an AUC value of 0.7218 (P value < 0.001). Conclusion The current study potentiates LINC00852/miR-145-5p axis as a possible contributor to the pathogenesis of breast cancer. |
| format | Article |
| id | doaj-art-83577bf4c3fa43c387e072ee1d3c4d11 |
| institution | OA Journals |
| issn | 2730-6011 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-83577bf4c3fa43c387e072ee1d3c4d112025-08-20T02:33:05ZengSpringerDiscover Oncology2730-60112024-11-0115111310.1007/s12672-024-01553-5Importance of LINC00852/miR-145-5p in breast cancer: a bioinformatics and experimental studyAbbas Shakoori0Asghar Hosseinzadeh1Nahid Nafisi2Ramesh Omranipour3Leyla Sahebi4Nazanin Hosseinkhan5Mohsen Ahmadi6Soudeh Ghafouri-Fard7Maryam Abtin8Department of Medical Genetics, School of Medicine, Tehran University of Medical SciencesDepartment of Biology Education, Farhangian UniversitySurgery Department, Rasoul Akram Hospital, Clinical Research Development Center (RCRDC), Iran University of Medical SciencesBreast Disease Research Center (BDRC), Tehran University of Medical SciencesMaternal, Fetal and Neonatal Research Center, Family Health Research Institute, Tehran University of Medical SciencesEndocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS)Department of Medical Genetics, Shahid Beheshti University of Medical SciencesDepartment of Medical Genetics, Shahid Beheshti University of Medical SciencesDepartment of Medical Genetics, School of Medicine, Tehran University of Medical SciencesAbstract Purpose We aimed to examine the importance of an lncRNA, namely LINC00852, in the pathogenesis of breast cancer. Materials and methods In the current study, we used several online tools to examine the importance of LINC00852 in breast cancer. Then, we examined these findings in 50 pairs of breast cancer tissues and adjacent non-cancerous ones. We also re-evaluated the data of miR-145-5p signature from our recent study. Results While in silico tools revealed down-regulation of LINC00852 in breast cancer samples, expression assays showed significant up-regulation of this lncRNAs in breast cancer samples compared with matching control samples from Iranian patients. miR-145-5p was under-expressed in breast cancer samples compared with non-cancerous samples. LINC00852 could separate breast cancer tissues from adjacent non-malignant tissues with an AUC value of 0.7218 (P value < 0.001). Conclusion The current study potentiates LINC00852/miR-145-5p axis as a possible contributor to the pathogenesis of breast cancer.https://doi.org/10.1007/s12672-024-01553-5LINC00852miR-145-5pBreast cancer |
| spellingShingle | Abbas Shakoori Asghar Hosseinzadeh Nahid Nafisi Ramesh Omranipour Leyla Sahebi Nazanin Hosseinkhan Mohsen Ahmadi Soudeh Ghafouri-Fard Maryam Abtin Importance of LINC00852/miR-145-5p in breast cancer: a bioinformatics and experimental study Discover Oncology LINC00852 miR-145-5p Breast cancer |
| title | Importance of LINC00852/miR-145-5p in breast cancer: a bioinformatics and experimental study |
| title_full | Importance of LINC00852/miR-145-5p in breast cancer: a bioinformatics and experimental study |
| title_fullStr | Importance of LINC00852/miR-145-5p in breast cancer: a bioinformatics and experimental study |
| title_full_unstemmed | Importance of LINC00852/miR-145-5p in breast cancer: a bioinformatics and experimental study |
| title_short | Importance of LINC00852/miR-145-5p in breast cancer: a bioinformatics and experimental study |
| title_sort | importance of linc00852 mir 145 5p in breast cancer a bioinformatics and experimental study |
| topic | LINC00852 miR-145-5p Breast cancer |
| url | https://doi.org/10.1007/s12672-024-01553-5 |
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