A NEW ALKALOID ISOLATED FROM Tabernaemontana hystrix Steud. (Apocynaceae) AND THE ANTIPROLIFERATIVE POTENTIAL OF THE ROOT BARK AGAINST HUMAN CERVICAL CANCER (HeLa)

A NEW ALKALOID ISOLATED FROM Tabernaemontana hystrix Steud. (Apocynaceae) AND THE ANTIPROLIFERATIVE POTENTIAL OF THE ROOT BARK AGAINST HUMAN CERVICAL CANCER (HeLa)

Cervical cancer is the fourth most common cancer in the world and the third most common in Brazilian women. The search for compounds with anticancer potential is important, since cancer is a public health problem, and some drugs may lead to side effects. In addition, cases of multidrug resistance ma...

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Main Authors: Thalya S. R. Nogueira, Thiago C. Sardou, Julio Cesar Thurler Júnior, Gabriela Dinis, Vinícius D’avila B. Pascoal, Lucas S. Abreu, Raimundo Braz Filho, Aislan C. R. F. Pascoal, Ivo José C. Vieira
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2025-06-01
Series:Química Nova
Subjects:
alkaloids
cervical cancer
HeLa
NIH-3T3
Tabernaemontana hystrix.
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422025000600301&lng=en&tlng=en
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Summary:Cervical cancer is the fourth most common cancer in the world and the third most common in Brazilian women. The search for compounds with anticancer potential is important, since cancer is a public health problem, and some drugs may lead to side effects. In addition, cases of multidrug resistance may occur. Tabernaemontana species are considered a promising source of bioactive compounds. The antiproliferative potential of the crude extract and fractions of Tabernaemontana hystrix Steud. (Apocynaceae) root bark were evaluated through MTT assays using HeLa cells and NIH-3T3 cells. It was observed that EtOAc and BuOH fractions were selective against tumor cells, with IC50 (half maximal inhibitory concentration) values of 3.787 and 8.489 μg mL-1, respectively. The phytochemical investigation of both fractions was carried out, leading to the isolation of six monoterpene indole alkaloids (MIAs): olivacine (1), affinine (2), the mixture of alkaloids 1, janetine (3) and 3,14-dihydro-olivacine (4), and macusine B (5) from the EtOAc fraction. However, the BuOH fraction also provided compounds 1 and 3, and the new MIA, named as Nb-demethyl-18-formyl-affinine (6). Compounds 3 and 4 are being reported for the first time in the species. Further research is needed to evaluate the antiproliferative potential of these compounds.
ISSN:1678-7064

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