A Nanomechanical Investigation of Engineered Bone Tissue Comparing Elastoplastic and Viscoelastoplastic Modeling
It is common practice to implement the elastoplastic Oliver and Pharr (OP) model to investigate the spatial and temporal variations of mechanical properties of engineered bone. However, the viscoelastoplastic (VEP) model may be preferred being envisaged to provide additional insights into the regene...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Advances in Materials Science and Engineering |
| Online Access: | http://dx.doi.org/10.1155/2017/7472513 |
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| author | Marco Boi Gregorio Marchiori Maria Sartori Francesca Salamanna Gabriela Graziani Alessandro Russo Andrea Visani Mauro Girolami Milena Fini Michele Bianchi |
| author_facet | Marco Boi Gregorio Marchiori Maria Sartori Francesca Salamanna Gabriela Graziani Alessandro Russo Andrea Visani Mauro Girolami Milena Fini Michele Bianchi |
| author_sort | Marco Boi |
| collection | DOAJ |
| description | It is common practice to implement the elastoplastic Oliver and Pharr (OP) model to investigate the spatial and temporal variations of mechanical properties of engineered bone. However, the viscoelastoplastic (VEP) model may be preferred being envisaged to provide additional insights into the regeneration process, as it allows evaluating also the viscous content of bone tissue. In this work, the elastic modulus (ER), contact hardness (HC), hardness (H), and viscosity index (ηQ) of newly formed bone tissue regenerated at 4 and 12 weeks from the implantation of a macroporous hydroxyapatite scaffold in a rabbit femoral critical-size model were addressed and compared to the mechanical properties of preexisting bone. Indentation curves were fitted with both the OP and VEP models. The VEP model outlined a wider gap between the mechanical properties of native and regenerated tissue when compared to the OP model. In addition, the VEP model indicated an increase of the viscosity index from 4 to 12 weeks, supporting the evidence of a still active regeneration process. The reported results confirmed the higher ability of VEP model compared to the more diffused OP model to provide important insights into bone mechanical properties, also during the bone regeneration process. |
| format | Article |
| id | doaj-art-834dbd1128b7424d9a3a2b43bf0ad5fe |
| institution | OA Journals |
| issn | 1687-8434 1687-8442 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Materials Science and Engineering |
| spelling | doaj-art-834dbd1128b7424d9a3a2b43bf0ad5fe2025-08-20T02:09:01ZengWileyAdvances in Materials Science and Engineering1687-84341687-84422017-01-01201710.1155/2017/74725137472513A Nanomechanical Investigation of Engineered Bone Tissue Comparing Elastoplastic and Viscoelastoplastic ModelingMarco Boi0Gregorio Marchiori1Maria Sartori2Francesca Salamanna3Gabriela Graziani4Alessandro Russo5Andrea Visani6Mauro Girolami7Milena Fini8Michele Bianchi9Rizzoli Orthopaedic Institute, NanoBiotechnology Laboratory (NaBi), Research Innovation and Technology Department (RIT), Via di Barbiano 1/10, 40136 Bologna, ItalyRizzoli Orthopaedic Institute, NanoBiotechnology Laboratory (NaBi), Research Innovation and Technology Department (RIT), Via di Barbiano 1/10, 40136 Bologna, ItalyRizzoli Orthopaedic Institute, Laboratory of Biocompatibility, Technological Innovations and Advanced Therapies, Research Innovation and Technology Department (RIT), Via di Barbiano 1/10, Bologna, ItalyRizzoli Orthopaedic Institute, Laboratory of Preclinical and Surgical Studies, 40136 Bologna, ItalyRizzoli Orthopaedic Institute, NanoBiotechnology Laboratory (NaBi), Research Innovation and Technology Department (RIT), Via di Barbiano 1/10, 40136 Bologna, ItalyRizzoli Orthopaedic Institute, NanoBiotechnology Laboratory (NaBi), Research Innovation and Technology Department (RIT), Via di Barbiano 1/10, 40136 Bologna, ItalyRizzoli Orthopaedic Institute, Laboratory of Biomechanics and Technology Innovation, Via di Barbiano 1/10, 40136 Bologna, ItalyRizzoli Orthopaedic Institute, Orthopedics and Traumatology Department, Via Pupilli 1, 40010 Bologna, ItalyRizzoli Orthopaedic Institute, Laboratory of Preclinical and Surgical Studies, 40136 Bologna, ItalyRizzoli Orthopaedic Institute, NanoBiotechnology Laboratory (NaBi), Research Innovation and Technology Department (RIT), Via di Barbiano 1/10, 40136 Bologna, ItalyIt is common practice to implement the elastoplastic Oliver and Pharr (OP) model to investigate the spatial and temporal variations of mechanical properties of engineered bone. However, the viscoelastoplastic (VEP) model may be preferred being envisaged to provide additional insights into the regeneration process, as it allows evaluating also the viscous content of bone tissue. In this work, the elastic modulus (ER), contact hardness (HC), hardness (H), and viscosity index (ηQ) of newly formed bone tissue regenerated at 4 and 12 weeks from the implantation of a macroporous hydroxyapatite scaffold in a rabbit femoral critical-size model were addressed and compared to the mechanical properties of preexisting bone. Indentation curves were fitted with both the OP and VEP models. The VEP model outlined a wider gap between the mechanical properties of native and regenerated tissue when compared to the OP model. In addition, the VEP model indicated an increase of the viscosity index from 4 to 12 weeks, supporting the evidence of a still active regeneration process. The reported results confirmed the higher ability of VEP model compared to the more diffused OP model to provide important insights into bone mechanical properties, also during the bone regeneration process.http://dx.doi.org/10.1155/2017/7472513 |
| spellingShingle | Marco Boi Gregorio Marchiori Maria Sartori Francesca Salamanna Gabriela Graziani Alessandro Russo Andrea Visani Mauro Girolami Milena Fini Michele Bianchi A Nanomechanical Investigation of Engineered Bone Tissue Comparing Elastoplastic and Viscoelastoplastic Modeling Advances in Materials Science and Engineering |
| title | A Nanomechanical Investigation of Engineered Bone Tissue Comparing Elastoplastic and Viscoelastoplastic Modeling |
| title_full | A Nanomechanical Investigation of Engineered Bone Tissue Comparing Elastoplastic and Viscoelastoplastic Modeling |
| title_fullStr | A Nanomechanical Investigation of Engineered Bone Tissue Comparing Elastoplastic and Viscoelastoplastic Modeling |
| title_full_unstemmed | A Nanomechanical Investigation of Engineered Bone Tissue Comparing Elastoplastic and Viscoelastoplastic Modeling |
| title_short | A Nanomechanical Investigation of Engineered Bone Tissue Comparing Elastoplastic and Viscoelastoplastic Modeling |
| title_sort | nanomechanical investigation of engineered bone tissue comparing elastoplastic and viscoelastoplastic modeling |
| url | http://dx.doi.org/10.1155/2017/7472513 |
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