Hyaluronic Acid: Perspectives in Upper Aero-Digestive Tract. A Systematic Review.
<h4>Background</h4>To date, topical therapies guarantee a better delivery of high concentrations of pharmacologic agents to the mucosa of the upper aerodigestive tract (UADT). The use of topical drugs, which are able to reduce mucosal inflammation and to improve healing tissues, can repr...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0130637&type=printable |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849470301670211584 |
|---|---|
| author | Manuele Casale Antonio Moffa Lorenzo Sabatino Annalisa Pace Giuseppe Oliveto Massimiliano Vitali Peter Baptista Fabrizio Salvinelli |
| author_facet | Manuele Casale Antonio Moffa Lorenzo Sabatino Annalisa Pace Giuseppe Oliveto Massimiliano Vitali Peter Baptista Fabrizio Salvinelli |
| author_sort | Manuele Casale |
| collection | DOAJ |
| description | <h4>Background</h4>To date, topical therapies guarantee a better delivery of high concentrations of pharmacologic agents to the mucosa of the upper aerodigestive tract (UADT). The use of topical drugs, which are able to reduce mucosal inflammation and to improve healing tissues, can represent a relevant therapeutic advance. Topical sodium hyaluronate (SH) has recently been recognized as adjuvant treatment in the chronic inflammatory disease of the UADT.<h4>Aims</h4>The aim of our work was to review the published literature regarding all the potential therapeutic effects of SH in the chronic inflammatory disease of UADT.<h4>Methods</h4>Relevant published studies were searched in Pubmed, Google Scholar, Ovid using keywords ("sodium hyaluronate" and "upper airways") or Medical Subject Headings.<h4>Results</h4>At the end of our selection process, sixteen publications have been included. Six of them in the post-operative period of nasal-sinus surgery, 2 of them in pediatric patients affected by recurrent upper respiratory tract infections, 4 of them in reducing symptoms and preventing exacerbations of chronic upper airways in adult population, 4 of them in patients with chronic inflammatory disease of UADT, including gastro-esophageal reflux disease (GERD).<h4>Conclusions</h4>Topical administration of SH plays a pivotkey role in the postoperative phase of patients undergoing FESS and nasal surgery, and positive results are generally observed in all the patients suffering from UADT chronic inflammatory disease. |
| format | Article |
| id | doaj-art-834d8707f9224f8a9bcceab453240db5 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-834d8707f9224f8a9bcceab453240db52025-08-20T03:25:11ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e013063710.1371/journal.pone.0130637Hyaluronic Acid: Perspectives in Upper Aero-Digestive Tract. A Systematic Review.Manuele CasaleAntonio MoffaLorenzo SabatinoAnnalisa PaceGiuseppe OlivetoMassimiliano VitaliPeter BaptistaFabrizio Salvinelli<h4>Background</h4>To date, topical therapies guarantee a better delivery of high concentrations of pharmacologic agents to the mucosa of the upper aerodigestive tract (UADT). The use of topical drugs, which are able to reduce mucosal inflammation and to improve healing tissues, can represent a relevant therapeutic advance. Topical sodium hyaluronate (SH) has recently been recognized as adjuvant treatment in the chronic inflammatory disease of the UADT.<h4>Aims</h4>The aim of our work was to review the published literature regarding all the potential therapeutic effects of SH in the chronic inflammatory disease of UADT.<h4>Methods</h4>Relevant published studies were searched in Pubmed, Google Scholar, Ovid using keywords ("sodium hyaluronate" and "upper airways") or Medical Subject Headings.<h4>Results</h4>At the end of our selection process, sixteen publications have been included. Six of them in the post-operative period of nasal-sinus surgery, 2 of them in pediatric patients affected by recurrent upper respiratory tract infections, 4 of them in reducing symptoms and preventing exacerbations of chronic upper airways in adult population, 4 of them in patients with chronic inflammatory disease of UADT, including gastro-esophageal reflux disease (GERD).<h4>Conclusions</h4>Topical administration of SH plays a pivotkey role in the postoperative phase of patients undergoing FESS and nasal surgery, and positive results are generally observed in all the patients suffering from UADT chronic inflammatory disease.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0130637&type=printable |
| spellingShingle | Manuele Casale Antonio Moffa Lorenzo Sabatino Annalisa Pace Giuseppe Oliveto Massimiliano Vitali Peter Baptista Fabrizio Salvinelli Hyaluronic Acid: Perspectives in Upper Aero-Digestive Tract. A Systematic Review. PLoS ONE |
| title | Hyaluronic Acid: Perspectives in Upper Aero-Digestive Tract. A Systematic Review. |
| title_full | Hyaluronic Acid: Perspectives in Upper Aero-Digestive Tract. A Systematic Review. |
| title_fullStr | Hyaluronic Acid: Perspectives in Upper Aero-Digestive Tract. A Systematic Review. |
| title_full_unstemmed | Hyaluronic Acid: Perspectives in Upper Aero-Digestive Tract. A Systematic Review. |
| title_short | Hyaluronic Acid: Perspectives in Upper Aero-Digestive Tract. A Systematic Review. |
| title_sort | hyaluronic acid perspectives in upper aero digestive tract a systematic review |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0130637&type=printable |
| work_keys_str_mv | AT manuelecasale hyaluronicacidperspectivesinupperaerodigestivetractasystematicreview AT antoniomoffa hyaluronicacidperspectivesinupperaerodigestivetractasystematicreview AT lorenzosabatino hyaluronicacidperspectivesinupperaerodigestivetractasystematicreview AT annalisapace hyaluronicacidperspectivesinupperaerodigestivetractasystematicreview AT giuseppeoliveto hyaluronicacidperspectivesinupperaerodigestivetractasystematicreview AT massimilianovitali hyaluronicacidperspectivesinupperaerodigestivetractasystematicreview AT peterbaptista hyaluronicacidperspectivesinupperaerodigestivetractasystematicreview AT fabriziosalvinelli hyaluronicacidperspectivesinupperaerodigestivetractasystematicreview |