Determining the long-term health burden and risk of sequelae for 14 foodborne infections in British Columbia, Canada: protocol for a retrospective population-based cohort study
Introduction Over one in eight Canadians is affected by a foodborne infection annually; however, the long-term consequences, including the risks and costs of sequelae, are unclear. We aim to estimate the health burden and direct costs of 14 infections commonly transmitted by food, considering the ac...
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| Format: | Article |
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BMJ Publishing Group
2020-08-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/8/e036560.full |
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| author | Gilaad G Kaplan Richard J Cook Dimitra Panagiotoglou David M Patrick Ashok Chaurasia Shannon E Majowicz Marsha Taylor Mahmood R Gohari Steen Ethelberg Eleni Galanis |
| author_facet | Gilaad G Kaplan Richard J Cook Dimitra Panagiotoglou David M Patrick Ashok Chaurasia Shannon E Majowicz Marsha Taylor Mahmood R Gohari Steen Ethelberg Eleni Galanis |
| author_sort | Gilaad G Kaplan |
| collection | DOAJ |
| description | Introduction Over one in eight Canadians is affected by a foodborne infection annually; however, the long-term consequences, including the risks and costs of sequelae, are unclear. We aim to estimate the health burden and direct costs of 14 infections commonly transmitted by food, considering the acute illness and subsequent sequelae and mortality, for the population of British Columbia, Canada (~4.7 million).Methods and analysis We will conduct a population-based retrospective cohort study of the British Columbia provincial population, over a 10-year study period (1 January 2005 to 31 December 2014). Exposure is defined as a provincially reported illness caused by Clostridium botulinum, Campylobacter, Cryptosporidium, Cyclospora, Giardia, hepatitis A virus, Listeria, non-typhoidal Salmonella spp, Salmonella Typhi, Salmonella Paratyphi, Shiga toxin-producing Escherichia coli, Shigella, Vibrio parahaemolyticus or Yersinia (excluding pestis). We will link individual-level longitudinal data from eight province-wide administrative health and reportable disease databases that include physician visits, hospitalisations and day surgeries, deaths, stillbirths, prescription medications (except those to treat HIV) and reportable foodborne diseases. Using these linked databases, we will investigate the likelihood of various sequelae and death. Hazard models will be used to estimate the risk of outcomes and their association with the type of foodborne infection. Epidemiological analyses will be conducted to determine the progression of illness and the fraction of sequelae attributable to specific foodborne infections. Economic analyses will assess the consequent direct healthcare costs.Ethics and dissemination This study has been approved by a University of Waterloo Research Ethics Committee (no 30645), the University of British Columbia Behavioral Research Ethics Board (no H16-00021) and McGill University’s Institutional Review Board (no A03-M12-19A). Results will be disseminated via presentations to academics, public health practitioners and knowledge users, and publication in peer-reviewed journals. Where such publications are not open access, manuscripts will also be available via the University of Waterloo’s Institutional Repository (https://uwspace.uwaterloo.ca). |
| format | Article |
| id | doaj-art-834d1923fcab492fa8e009cd22dbcba7 |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-08-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-834d1923fcab492fa8e009cd22dbcba72025-08-20T02:51:14ZengBMJ Publishing GroupBMJ Open2044-60552020-08-0110810.1136/bmjopen-2019-036560Determining the long-term health burden and risk of sequelae for 14 foodborne infections in British Columbia, Canada: protocol for a retrospective population-based cohort studyGilaad G Kaplan0Richard J Cook1Dimitra Panagiotoglou2David M Patrick3Ashok Chaurasia4Shannon E Majowicz5Marsha Taylor6Mahmood R Gohari7Steen Ethelberg8Eleni Galanis91 Department of Medicine, University of Calgary, Calgary, Alberta, CanadaDepartment of Statistics and Actuarial Science, University of Waterloo, Waterloo, Ontario, CanadaDepartment of Epidemiology and Biostatistics, School of Population and Global Health, McGill University, Montréal, Québec, CanadaBritish Columbia Centre for Disease Control, Vancouver, British Columbia, CanadaPublic Health and Health Systems, Faculty of Applied Health Sciences, University of Waterloo, Waterloo, Ontario, CanadaSchool of Public Health Sciences, University of Waterloo, Waterloo, Ontario, CanadaBritish Columbia Centre for Disease Control, Vancouver, British Columbia, CanadaSchool of Public Health and Health Systems, University of Waterloo, Waterloo, Ontario, Canada1 Department of Infectious Disease Epidemiology and Prevention, Statens Serum Institut, Copenhagen, DenmarkBritish Columbia Centre for Disease Control, Vancouver, British Columbia, CanadaIntroduction Over one in eight Canadians is affected by a foodborne infection annually; however, the long-term consequences, including the risks and costs of sequelae, are unclear. We aim to estimate the health burden and direct costs of 14 infections commonly transmitted by food, considering the acute illness and subsequent sequelae and mortality, for the population of British Columbia, Canada (~4.7 million).Methods and analysis We will conduct a population-based retrospective cohort study of the British Columbia provincial population, over a 10-year study period (1 January 2005 to 31 December 2014). Exposure is defined as a provincially reported illness caused by Clostridium botulinum, Campylobacter, Cryptosporidium, Cyclospora, Giardia, hepatitis A virus, Listeria, non-typhoidal Salmonella spp, Salmonella Typhi, Salmonella Paratyphi, Shiga toxin-producing Escherichia coli, Shigella, Vibrio parahaemolyticus or Yersinia (excluding pestis). We will link individual-level longitudinal data from eight province-wide administrative health and reportable disease databases that include physician visits, hospitalisations and day surgeries, deaths, stillbirths, prescription medications (except those to treat HIV) and reportable foodborne diseases. Using these linked databases, we will investigate the likelihood of various sequelae and death. Hazard models will be used to estimate the risk of outcomes and their association with the type of foodborne infection. Epidemiological analyses will be conducted to determine the progression of illness and the fraction of sequelae attributable to specific foodborne infections. Economic analyses will assess the consequent direct healthcare costs.Ethics and dissemination This study has been approved by a University of Waterloo Research Ethics Committee (no 30645), the University of British Columbia Behavioral Research Ethics Board (no H16-00021) and McGill University’s Institutional Review Board (no A03-M12-19A). Results will be disseminated via presentations to academics, public health practitioners and knowledge users, and publication in peer-reviewed journals. Where such publications are not open access, manuscripts will also be available via the University of Waterloo’s Institutional Repository (https://uwspace.uwaterloo.ca).https://bmjopen.bmj.com/content/10/8/e036560.full |
| spellingShingle | Gilaad G Kaplan Richard J Cook Dimitra Panagiotoglou David M Patrick Ashok Chaurasia Shannon E Majowicz Marsha Taylor Mahmood R Gohari Steen Ethelberg Eleni Galanis Determining the long-term health burden and risk of sequelae for 14 foodborne infections in British Columbia, Canada: protocol for a retrospective population-based cohort study BMJ Open |
| title | Determining the long-term health burden and risk of sequelae for 14 foodborne infections in British Columbia, Canada: protocol for a retrospective population-based cohort study |
| title_full | Determining the long-term health burden and risk of sequelae for 14 foodborne infections in British Columbia, Canada: protocol for a retrospective population-based cohort study |
| title_fullStr | Determining the long-term health burden and risk of sequelae for 14 foodborne infections in British Columbia, Canada: protocol for a retrospective population-based cohort study |
| title_full_unstemmed | Determining the long-term health burden and risk of sequelae for 14 foodborne infections in British Columbia, Canada: protocol for a retrospective population-based cohort study |
| title_short | Determining the long-term health burden and risk of sequelae for 14 foodborne infections in British Columbia, Canada: protocol for a retrospective population-based cohort study |
| title_sort | determining the long term health burden and risk of sequelae for 14 foodborne infections in british columbia canada protocol for a retrospective population based cohort study |
| url | https://bmjopen.bmj.com/content/10/8/e036560.full |
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