NET Models Meeting 2024 white paper: the current state of neuroendocrine tumour research models and our future aspirations
Current models for the study of neuroendocrine tumours (NETs) are severely limited. While in vitro (e.g. cell lines), ex vivo (e.g. organoids) and in vivo (e.g. mice) models all exist, each has limitations. To address these limitations and collectively identify strategies to move the NET models fiel...
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Bioscientifica
2024-12-01
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| Series: | Endocrine Oncology |
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| Online Access: | https://eo.bioscientifica.com/view/journals/eo/4/1/EO-24-0055.xml |
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| author | Po Hien Ear Ilaria Marinoni Talya Dayton Rachael Guenter Dawn E Quelle Anna Battistella Floryne O Buishand Suganthi Chittaranjan Yi-Cheih Nancy Du Ines Marques Natalia S Pellegata Samira M Sadowski Amit Tirosh Simon April-Monn Cinzia Aurilia Renata Jaskula-Sztul Maria Jesús Baena Moreno Simone Donati Katherine A English Maria Almudena Hernandez Llorens Harry Hodgetts Francesca Marini Maria Martins Gaia Palmini Beatriz Soldevilla Jörg Schrader Rajesh V Thakker Kate E Lines |
| author_facet | Po Hien Ear Ilaria Marinoni Talya Dayton Rachael Guenter Dawn E Quelle Anna Battistella Floryne O Buishand Suganthi Chittaranjan Yi-Cheih Nancy Du Ines Marques Natalia S Pellegata Samira M Sadowski Amit Tirosh Simon April-Monn Cinzia Aurilia Renata Jaskula-Sztul Maria Jesús Baena Moreno Simone Donati Katherine A English Maria Almudena Hernandez Llorens Harry Hodgetts Francesca Marini Maria Martins Gaia Palmini Beatriz Soldevilla Jörg Schrader Rajesh V Thakker Kate E Lines |
| author_sort | Po Hien Ear |
| collection | DOAJ |
| description | Current models for the study of neuroendocrine tumours (NETs) are severely limited. While in vitro (e.g. cell lines), ex vivo (e.g. organoids) and in vivo (e.g. mice) models all exist, each has limitations. To address these limitations and collectively identify strategies to move the NET models field forward, we held an inaugural NET models meeting, hosted by our founding group: Dr Lines (Oxford), Prof. Quelle (Iowa), Dr Dayton (Barcelona), Dr Ear (Iowa), Dr Marinoni (Bern) and Dr Guenter (Alabama). This two-day meeting in Oxford (UK) was organised and supported by Bioscientifica Ltd and was solely dedicated to the discussion of NET models. The meeting was attended by ∼30 international researchers (from the UK, EU, Israel, USA and Canada). Plenary talks were given by Prof. Thakker, who summarised NET research over the past few decades, and Dr Schrader, who described the process and pitfalls of generating new cell lines. Eight researchers also presented their work on topics ranging from human cell 3D bioprinting to zebrafish models and included novel ideas and improvements on current concepts. This was followed by an interactive workshop, where discussion topics included a summary of currently available NET models, limitations of these models, barriers to developing new models, and how we can address these issues going forward. This white paper summarises the key points raised in these discussions and the future aspirations of the NET Models Consortium. The next meeting will take place in Oxford (UK) in 2025; contact contact@netcancerfoundation.com for more information. |
| format | Article |
| id | doaj-art-833e53b14d1245a1ae42683f17adb30f |
| institution | OA Journals |
| issn | 2634-4793 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Oncology |
| spelling | doaj-art-833e53b14d1245a1ae42683f17adb30f2025-08-20T01:57:20ZengBioscientificaEndocrine Oncology2634-47932024-12-014110.1530/EO-24-00551NET Models Meeting 2024 white paper: the current state of neuroendocrine tumour research models and our future aspirationsPo Hien Ear0Ilaria Marinoni1Talya Dayton2Rachael Guenter3Dawn E Quelle4Anna Battistella5Floryne O Buishand6Suganthi Chittaranjan7Yi-Cheih Nancy Du8Ines Marques9Natalia S Pellegata10Samira M Sadowski11Amit Tirosh12Simon April-Monn13Cinzia Aurilia14Renata Jaskula-Sztul15Maria Jesús Baena Moreno16Simone Donati17Katherine A English18Maria Almudena Hernandez Llorens19Harry Hodgetts20Francesca Marini21Maria Martins22Gaia Palmini23Beatriz Soldevilla24Jörg Schrader25Rajesh V Thakker26Kate E Lines27Department of Surgery, University of Iowa, Iowa City, Iowa, USAInstitute of Tissue Medicine and Pathology, University of Bern, Bern, SwitzerlandEuropean Molecular Biology Laboratory (EMBL) Barcelona, Tissue Biology and Disease Modelling, Barcelona, SpainDepartment of Surgery, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USADepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, Iowa, USAPancreatic Surgery Unit, Pancreas Translational and Clinical Research Center, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, ItalyDepartment of Clinical Science and Services, Royal Veterinary College, Hatfield, UKDepartment of Genome Sciences Centre, BC Cancer, Vancouver, British Columbia, CanadaDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York, USAInstitute of Anatomy, University of Bern, Bern, SwitzerlandDepartment of Biology and Biotechnology, University of Pavia, Pavia, ItalyEndocrine Surgery Section, Surgical Oncology Program, Center for Cancer Research, NCI, NIH, Bethesda, Maryland, USAENTIRE – Endocrine Neoplasia Translational Research Center, Sheba Medical Center, and Tel Aviv University Faculty of Medicine, Tel Aviv, IsraelDepartment of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, SwitzerlandAssociazione Italiana Neoplasie Endocrine Multiple di tipo 1 e di tipo 2 (AIMEN 1 e 2), Sondrio, ItalyDepartment of Surgery, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USACenter of Experimental Oncology, Gastrointestinal and Neuroendocrine Tumors Research Group, Research Institute Hospital 12 de Octubre (i+12), Madrid, SpainAssociazione Italiana Neoplasie Endocrine Multiple di tipo 1 e di tipo 2 (AIMEN 1 e 2), Sondrio, ItalyOCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UKCenter of Experimental Oncology, Gastrointestinal and Neuroendocrine Tumors Research Group, Research Institute Hospital 12 de Octubre (i+12), Madrid, SpainRegenerative Medicine and Fibrosis Group, Institute for Liver and Digestive Health, University College London, Royal Free Campus, London, UKFIRMO Foundation (Italian Foundation for the Research on Bone Diseases), Florence, ItalyRegenerative Medicine and Fibrosis Group, Institute for Liver and Digestive Health, University College London, Royal Free Campus, London, UKFIRMO Foundation (Italian Foundation for the Research on Bone Diseases), Florence, ItalyCenter of Experimental Oncology, Gastrointestinal and Neuroendocrine Tumors Research Group, Research Institute Hospital 12 de Octubre (i+12), Madrid, SpainDepartment of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyOCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UKOCDEM, Radcliffe Department of Medicine, University of Oxford, Churchill Hospital, Oxford, UKCurrent models for the study of neuroendocrine tumours (NETs) are severely limited. While in vitro (e.g. cell lines), ex vivo (e.g. organoids) and in vivo (e.g. mice) models all exist, each has limitations. To address these limitations and collectively identify strategies to move the NET models field forward, we held an inaugural NET models meeting, hosted by our founding group: Dr Lines (Oxford), Prof. Quelle (Iowa), Dr Dayton (Barcelona), Dr Ear (Iowa), Dr Marinoni (Bern) and Dr Guenter (Alabama). This two-day meeting in Oxford (UK) was organised and supported by Bioscientifica Ltd and was solely dedicated to the discussion of NET models. The meeting was attended by ∼30 international researchers (from the UK, EU, Israel, USA and Canada). Plenary talks were given by Prof. Thakker, who summarised NET research over the past few decades, and Dr Schrader, who described the process and pitfalls of generating new cell lines. Eight researchers also presented their work on topics ranging from human cell 3D bioprinting to zebrafish models and included novel ideas and improvements on current concepts. This was followed by an interactive workshop, where discussion topics included a summary of currently available NET models, limitations of these models, barriers to developing new models, and how we can address these issues going forward. This white paper summarises the key points raised in these discussions and the future aspirations of the NET Models Consortium. The next meeting will take place in Oxford (UK) in 2025; contact contact@netcancerfoundation.com for more information.https://eo.bioscientifica.com/view/journals/eo/4/1/EO-24-0055.xmlin vitroex vivoin vivoconsortium |
| spellingShingle | Po Hien Ear Ilaria Marinoni Talya Dayton Rachael Guenter Dawn E Quelle Anna Battistella Floryne O Buishand Suganthi Chittaranjan Yi-Cheih Nancy Du Ines Marques Natalia S Pellegata Samira M Sadowski Amit Tirosh Simon April-Monn Cinzia Aurilia Renata Jaskula-Sztul Maria Jesús Baena Moreno Simone Donati Katherine A English Maria Almudena Hernandez Llorens Harry Hodgetts Francesca Marini Maria Martins Gaia Palmini Beatriz Soldevilla Jörg Schrader Rajesh V Thakker Kate E Lines NET Models Meeting 2024 white paper: the current state of neuroendocrine tumour research models and our future aspirations Endocrine Oncology in vitro ex vivo in vivo consortium |
| title | NET Models Meeting 2024 white paper: the current state of neuroendocrine tumour research models and our future aspirations |
| title_full | NET Models Meeting 2024 white paper: the current state of neuroendocrine tumour research models and our future aspirations |
| title_fullStr | NET Models Meeting 2024 white paper: the current state of neuroendocrine tumour research models and our future aspirations |
| title_full_unstemmed | NET Models Meeting 2024 white paper: the current state of neuroendocrine tumour research models and our future aspirations |
| title_short | NET Models Meeting 2024 white paper: the current state of neuroendocrine tumour research models and our future aspirations |
| title_sort | net models meeting 2024 white paper the current state of neuroendocrine tumour research models and our future aspirations |
| topic | in vitro ex vivo in vivo consortium |
| url | https://eo.bioscientifica.com/view/journals/eo/4/1/EO-24-0055.xml |
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