Molecular diagnosis of nasopharyngeal carcinoma: Past and future
Nasopharyngeal carcinoma (NPC) is a malignant tumor originated from the nasopharynx epithelial cells and has been linked with Epstein-Barr virus (EBV) infection, dietary habits, environmental and genetic factors. It is a common malignancy in Southeast Asia, especially with gender preference among me...
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Elsevier
2025-02-01
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| Series: | Biomedical Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2319417024000519 |
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| author | Cheng-Lung Hsu Yu-Sun Chang Hsin-Pai Li |
| author_facet | Cheng-Lung Hsu Yu-Sun Chang Hsin-Pai Li |
| author_sort | Cheng-Lung Hsu |
| collection | DOAJ |
| description | Nasopharyngeal carcinoma (NPC) is a malignant tumor originated from the nasopharynx epithelial cells and has been linked with Epstein-Barr virus (EBV) infection, dietary habits, environmental and genetic factors. It is a common malignancy in Southeast Asia, especially with gender preference among men. Due to its non-specific symptoms, NPC is often diagnosed at a late stage. Thus, the molecular diagnosis of NPC plays a crucial role in early detection, treatment selection, disease monitoring, and prognosis prediction. This review aims to provide a summary of the current state and the latest emerging molecular diagnostic techniques for NPC, including EBV-related biomarkers, gene mutations, liquid biopsy, and DNA methylation. Challenges and potential future directions of NPC molecular diagnosis will be discussed. |
| format | Article |
| id | doaj-art-8337263ea0694a4680caf20b3cd1dc23 |
| institution | Kabale University |
| issn | 2319-4170 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedical Journal |
| spelling | doaj-art-8337263ea0694a4680caf20b3cd1dc232025-08-20T03:42:44ZengElsevierBiomedical Journal2319-41702025-02-0148110074810.1016/j.bj.2024.100748Molecular diagnosis of nasopharyngeal carcinoma: Past and futureCheng-Lung Hsu0Yu-Sun Chang1Hsin-Pai Li2Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan; School of Medicine, Chang Gung University, Taoyuan, TaiwanGraduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan; Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan; Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, TaiwanDivision of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Biomedical Sciences, Chang Gung University, Taoyuan, Taiwan; Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan; Department of Microbiology and Immunology, Chang Gung University, Taoyuan, Taiwan; Corresponding author. Department of Microbiology and Immunology, Chang Gung University, No.259, Wenhua 1st Rd., Guishan Dist., Taoyuan City 33302, Taiwan.Nasopharyngeal carcinoma (NPC) is a malignant tumor originated from the nasopharynx epithelial cells and has been linked with Epstein-Barr virus (EBV) infection, dietary habits, environmental and genetic factors. It is a common malignancy in Southeast Asia, especially with gender preference among men. Due to its non-specific symptoms, NPC is often diagnosed at a late stage. Thus, the molecular diagnosis of NPC plays a crucial role in early detection, treatment selection, disease monitoring, and prognosis prediction. This review aims to provide a summary of the current state and the latest emerging molecular diagnostic techniques for NPC, including EBV-related biomarkers, gene mutations, liquid biopsy, and DNA methylation. Challenges and potential future directions of NPC molecular diagnosis will be discussed.http://www.sciencedirect.com/science/article/pii/S2319417024000519Nasopharyngeal carcinoma (NPC)Epstein-Barr virus (EBV)Molecular diagnosis |
| spellingShingle | Cheng-Lung Hsu Yu-Sun Chang Hsin-Pai Li Molecular diagnosis of nasopharyngeal carcinoma: Past and future Biomedical Journal Nasopharyngeal carcinoma (NPC) Epstein-Barr virus (EBV) Molecular diagnosis |
| title | Molecular diagnosis of nasopharyngeal carcinoma: Past and future |
| title_full | Molecular diagnosis of nasopharyngeal carcinoma: Past and future |
| title_fullStr | Molecular diagnosis of nasopharyngeal carcinoma: Past and future |
| title_full_unstemmed | Molecular diagnosis of nasopharyngeal carcinoma: Past and future |
| title_short | Molecular diagnosis of nasopharyngeal carcinoma: Past and future |
| title_sort | molecular diagnosis of nasopharyngeal carcinoma past and future |
| topic | Nasopharyngeal carcinoma (NPC) Epstein-Barr virus (EBV) Molecular diagnosis |
| url | http://www.sciencedirect.com/science/article/pii/S2319417024000519 |
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