Cross-sectional Study to Assess Ocular Surface and Tear Film Status in Patients on Topical Antiglaucoma Therapy
Aim and background: To assess ocular surface and tear film status in patients on topical antiglaucoma medication. When monotherapy proves insufficient, polytherapy and drug combinations are used. Long-term use of multiple topical medications is correlated with ocular irritation and tear film instabi...
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Jaypee Brothers Medical Publisher
2025-06-01
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| Series: | Journal of Medical Academics |
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| Online Access: | https://www.jmaacms.com/doi/JOMA/pdf/10.5005/jp-journals-11003-0160 |
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| author | Jayshri B Pandhre Sanjiv Agrawal Radhika Umale Amogha U Mahale |
| author_facet | Jayshri B Pandhre Sanjiv Agrawal Radhika Umale Amogha U Mahale |
| author_sort | Jayshri B Pandhre |
| collection | DOAJ |
| description | Aim and background: To assess ocular surface and tear film status in patients on topical antiglaucoma medication. When monotherapy proves insufficient, polytherapy and drug combinations are used. Long-term use of multiple topical medications is correlated with ocular irritation and tear film instability.
Materials and methods: This observational cross-sectional study involved 81 eyes from 43 patients receiving antiglaucoma medications. Among them, 18 patients (<i>n</i> = 34) were using single medications, while 25 patients (<i>n</i> = 47) were on two or more medications. The assessment included corneal staining with fluorescein, impression cytology of the conjunctiva, the Schirmer test, and tear film break-up time (TBUT).
Results: The percentage of ocular surface alterations varied from 9 to 70%, and abnormal tear film status varied from 32 to 72%. The subjects in the polytherapy group had higher corneal staining (70 vs 47%, <i>p</i> = 0.0354, significant) and abnormal (72 vs 59%, <i>p</i> = 0.0005, significant). The percentage of abnormal impression cytology reports (9 vs 4%, <i>p</i> = 0.4804) and Schirmer test results were almost equal in both groups.
Conclusion: Ocular surface disorders (OSD) are more common in polytherapy, as they are in all antiglaucoma medication users. However, the tear film status is more significantly affected in subjects on polytherapy. |
| format | Article |
| id | doaj-art-832da77fdef847ee925e94c7c0bfb9cc |
| institution | Kabale University |
| issn | 2581-8279 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Jaypee Brothers Medical Publisher |
| record_format | Article |
| series | Journal of Medical Academics |
| spelling | doaj-art-832da77fdef847ee925e94c7c0bfb9cc2025-08-20T03:40:43ZengJaypee Brothers Medical PublisherJournal of Medical Academics2581-82792025-06-0181111510.5005/jp-journals-11003-01604Cross-sectional Study to Assess Ocular Surface and Tear Film Status in Patients on Topical Antiglaucoma TherapyJayshri B Pandhre0https://orcid.org/0009-0009-4788-6041Sanjiv Agrawal1Radhika Umale2Amogha U Mahale3https://orcid.org/0009-0008-5367-6350Jayshri B Pandhre, Department of Ophthalmology, Bharati Vidyapeeth (Deemed to be University) Medical College, Pune, Maharashtra, India, Phone: +91 9689067208Department of Ophthalmology, Bharati Vidyapeeth (Deemed to be University) Medical College, Pune, Maharashtra, IndiaDepartment of Ophthalmology, Bharati Vidyapeeth (Deemed to be University) Medical College, Pune, Maharashtra, IndiaDepartment of Ophthalmology, Bharati Vidyapeeth (Deemed to be University) Medical College, Pune, Maharashtra, IndiaAim and background: To assess ocular surface and tear film status in patients on topical antiglaucoma medication. When monotherapy proves insufficient, polytherapy and drug combinations are used. Long-term use of multiple topical medications is correlated with ocular irritation and tear film instability. Materials and methods: This observational cross-sectional study involved 81 eyes from 43 patients receiving antiglaucoma medications. Among them, 18 patients (<i>n</i> = 34) were using single medications, while 25 patients (<i>n</i> = 47) were on two or more medications. The assessment included corneal staining with fluorescein, impression cytology of the conjunctiva, the Schirmer test, and tear film break-up time (TBUT). Results: The percentage of ocular surface alterations varied from 9 to 70%, and abnormal tear film status varied from 32 to 72%. The subjects in the polytherapy group had higher corneal staining (70 vs 47%, <i>p</i> = 0.0354, significant) and abnormal (72 vs 59%, <i>p</i> = 0.0005, significant). The percentage of abnormal impression cytology reports (9 vs 4%, <i>p</i> = 0.4804) and Schirmer test results were almost equal in both groups. Conclusion: Ocular surface disorders (OSD) are more common in polytherapy, as they are in all antiglaucoma medication users. However, the tear film status is more significantly affected in subjects on polytherapy.https://www.jmaacms.com/doi/JOMA/pdf/10.5005/jp-journals-11003-0160antiglaucomaglaucomaocular surface diseasepreservative-freetear film |
| spellingShingle | Jayshri B Pandhre Sanjiv Agrawal Radhika Umale Amogha U Mahale Cross-sectional Study to Assess Ocular Surface and Tear Film Status in Patients on Topical Antiglaucoma Therapy Journal of Medical Academics antiglaucoma glaucoma ocular surface disease preservative-free tear film |
| title | Cross-sectional Study to Assess Ocular Surface and Tear Film Status in Patients on Topical Antiglaucoma Therapy |
| title_full | Cross-sectional Study to Assess Ocular Surface and Tear Film Status in Patients on Topical Antiglaucoma Therapy |
| title_fullStr | Cross-sectional Study to Assess Ocular Surface and Tear Film Status in Patients on Topical Antiglaucoma Therapy |
| title_full_unstemmed | Cross-sectional Study to Assess Ocular Surface and Tear Film Status in Patients on Topical Antiglaucoma Therapy |
| title_short | Cross-sectional Study to Assess Ocular Surface and Tear Film Status in Patients on Topical Antiglaucoma Therapy |
| title_sort | cross sectional study to assess ocular surface and tear film status in patients on topical antiglaucoma therapy |
| topic | antiglaucoma glaucoma ocular surface disease preservative-free tear film |
| url | https://www.jmaacms.com/doi/JOMA/pdf/10.5005/jp-journals-11003-0160 |
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