Whitening toothpaste-induced oral mucosal hypersensitivity reaction resembling oral lichenoid reaction: a clinically diagnosed case report
This case report describes an instance of oral mucosal hypersensitive reaction resembling oral lichenoid reaction (OLR) induced by the use of a whitening toothpaste in a 28-year-old female patient presenting with extensive white hypersensitive reaction on the oral mucosa. The clinical features resem...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Oral Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/froh.2025.1601156/full |
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| author | Fumin Zheng Fumin Zheng Yang Liu Yang Liu Mei Yang Xixi Yu Wanchun Wang |
| author_facet | Fumin Zheng Fumin Zheng Yang Liu Yang Liu Mei Yang Xixi Yu Wanchun Wang |
| author_sort | Fumin Zheng |
| collection | DOAJ |
| description | This case report describes an instance of oral mucosal hypersensitive reaction resembling oral lichenoid reaction (OLR) induced by the use of a whitening toothpaste in a 28-year-old female patient presenting with extensive white hypersensitive reaction on the oral mucosa. The clinical features resembled an oral mucosal hypersensitivity reaction with lichenoid morphology. A detailed history revealed a clear temporal association between the onset of the reaction and the use of whitening toothpaste. Symptoms rapidly improved following discontinuation of the product, and a positive rechallenge test further confirmed the causal relationship. In conjunction with a review of the literature, the potential pathogenic mechanisms of abrasive agents (e.g., calcium carbonate), chemical agents [e.g., hydrogen peroxide (HP), sodium lauryl sulfate (SLS)], and other additives in whitening toothpaste are discussed. This case documents the first confirmed association between whitening toothpaste and an oral mucosal hypersensitivity reaction with lichenoid morphology, highlighting the importance of differentiating hypersensitivity mechanisms in lichenoid-like presentations. |
| format | Article |
| id | doaj-art-832d347ffa6b48fcb9c07bde2c19d526 |
| institution | DOAJ |
| issn | 2673-4842 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oral Health |
| spelling | doaj-art-832d347ffa6b48fcb9c07bde2c19d5262025-08-20T02:41:11ZengFrontiers Media S.A.Frontiers in Oral Health2673-48422025-07-01610.3389/froh.2025.16011561601156Whitening toothpaste-induced oral mucosal hypersensitivity reaction resembling oral lichenoid reaction: a clinically diagnosed case reportFumin Zheng0Fumin Zheng1Yang Liu2Yang Liu3Mei Yang4Xixi Yu5Wanchun Wang6Department of Oral Medicine, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, Shandong, ChinaSchool of Stomatology, Qingdao University, Qingdao, Shandong, ChinaDepartment of Oral Medicine, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, Shandong, ChinaSchool of Stomatology, Binzhou Medical University, Yantai, Shandong, ChinaDepartment of Oral Medicine, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, Shandong, ChinaDepartment of Oral Medicine, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, Shandong, ChinaDepartment of Oral Medicine, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, Shandong, ChinaThis case report describes an instance of oral mucosal hypersensitive reaction resembling oral lichenoid reaction (OLR) induced by the use of a whitening toothpaste in a 28-year-old female patient presenting with extensive white hypersensitive reaction on the oral mucosa. The clinical features resembled an oral mucosal hypersensitivity reaction with lichenoid morphology. A detailed history revealed a clear temporal association between the onset of the reaction and the use of whitening toothpaste. Symptoms rapidly improved following discontinuation of the product, and a positive rechallenge test further confirmed the causal relationship. In conjunction with a review of the literature, the potential pathogenic mechanisms of abrasive agents (e.g., calcium carbonate), chemical agents [e.g., hydrogen peroxide (HP), sodium lauryl sulfate (SLS)], and other additives in whitening toothpaste are discussed. This case documents the first confirmed association between whitening toothpaste and an oral mucosal hypersensitivity reaction with lichenoid morphology, highlighting the importance of differentiating hypersensitivity mechanisms in lichenoid-like presentations.https://www.frontiersin.org/articles/10.3389/froh.2025.1601156/fulloral lichenoid reactionoral lichen planuswhitening toothpastehypersensitive reactionhypersensitive components |
| spellingShingle | Fumin Zheng Fumin Zheng Yang Liu Yang Liu Mei Yang Xixi Yu Wanchun Wang Whitening toothpaste-induced oral mucosal hypersensitivity reaction resembling oral lichenoid reaction: a clinically diagnosed case report Frontiers in Oral Health oral lichenoid reaction oral lichen planus whitening toothpaste hypersensitive reaction hypersensitive components |
| title | Whitening toothpaste-induced oral mucosal hypersensitivity reaction resembling oral lichenoid reaction: a clinically diagnosed case report |
| title_full | Whitening toothpaste-induced oral mucosal hypersensitivity reaction resembling oral lichenoid reaction: a clinically diagnosed case report |
| title_fullStr | Whitening toothpaste-induced oral mucosal hypersensitivity reaction resembling oral lichenoid reaction: a clinically diagnosed case report |
| title_full_unstemmed | Whitening toothpaste-induced oral mucosal hypersensitivity reaction resembling oral lichenoid reaction: a clinically diagnosed case report |
| title_short | Whitening toothpaste-induced oral mucosal hypersensitivity reaction resembling oral lichenoid reaction: a clinically diagnosed case report |
| title_sort | whitening toothpaste induced oral mucosal hypersensitivity reaction resembling oral lichenoid reaction a clinically diagnosed case report |
| topic | oral lichenoid reaction oral lichen planus whitening toothpaste hypersensitive reaction hypersensitive components |
| url | https://www.frontiersin.org/articles/10.3389/froh.2025.1601156/full |
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