Haematological Manifestations in Children with Extended Drug-Resistant Salmonella Typhi Infections in a Tertiary Care Hospital
OBJECTIVE: To analyze the haematological parameters in children affected by extended drug-resistant salmonella typhi (XDR S. typhi) infections in a Tertiary care hospital. METHODOLOGY: This Descriptive Cross-Sectional study was carried out at the Department of Haematology at PNS SHIFA Hospital,...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Liaquat University of Medical and Health Sciences
2024-03-01
|
| Series: | JLUMHS |
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850207954179981312 |
|---|---|
| author | Nazish Tahir Saeed Akhtar Khan Khattak Nighat Jamal Ghulam Murtaza Shaikh Rabia Ahme Waleed Ahmed |
| author_facet | Nazish Tahir Saeed Akhtar Khan Khattak Nighat Jamal Ghulam Murtaza Shaikh Rabia Ahme Waleed Ahmed |
| author_sort | Nazish Tahir |
| collection | DOAJ |
| description |
OBJECTIVE: To analyze the haematological parameters in children affected by extended drug-resistant salmonella typhi (XDR S. typhi) infections in a Tertiary care hospital.
METHODOLOGY: This Descriptive Cross-Sectional study was carried out at the Department of Haematology at PNS SHIFA Hospital, Karachi, from November 2021 to October 2022. Seventy children with XDR S. Typhi on blood culture were selected using a consecutive sampling technique. The study focused on haematological parameters, i.e., haemoglobin (Hb), WBC count, and platelet count. Descriptive statistics were expressed as mean ±SD, and the Chi-square test was applied. A p-value ≤0.05 was considered statistically significant.
RESULTS: Out of the total of 70 children (under 12 years of age) included in the study, 41 (58.6%) were male and 29 (41.4%) were female. The mean age was 8.17±2.92 years. Anaemia was observed in 51% percent of cases. Leucopenia and thrombocytopenia were noted in 44% and 54% of cases. Seventeen children had bicytopenia, while pancytopenia was seen in only two children.
CONCLUSION: XDR S. Typhi infection causes significant cytopenias. Therefore, patients with a history of sustained fever with cytopenias should be worked up for possible XDR S. Typhi infection. |
| format | Article |
| id | doaj-art-83254bf8ae9041b896a8790f42adea02 |
| institution | OA Journals |
| issn | 1729-0341 2309-8627 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Liaquat University of Medical and Health Sciences |
| record_format | Article |
| series | JLUMHS |
| spelling | doaj-art-83254bf8ae9041b896a8790f42adea022025-08-20T02:10:20ZengLiaquat University of Medical and Health SciencesJLUMHS1729-03412309-86272024-03-01231535710.22442/jlumhs.2024.01082Haematological Manifestations in Children with Extended Drug-Resistant Salmonella Typhi Infections in a Tertiary Care HospitalNazish Tahir0Saeed Akhtar Khan Khattak1Nighat Jamal2Ghulam Murtaza Shaikh3Rabia Ahme 4 Waleed Ahmed5Department of Pathology, PNS Shifa, Karachi, Sindh-PakistanDepartment of Pathology, PNS Shifa, Karachi, Sindh-PakistanDepartment of Pathology, PNS Shifa, Karachi, Sindh-PakistanDepartment of Pathology, PNS Shifa, Karachi, Sindh-PakistanDepartment of Pathology, PNS Shifa, Karachi, Sindh-PakistanDepartment of Pathology, PNS Shifa, Karachi, Sindh-Pakistan OBJECTIVE: To analyze the haematological parameters in children affected by extended drug-resistant salmonella typhi (XDR S. typhi) infections in a Tertiary care hospital. METHODOLOGY: This Descriptive Cross-Sectional study was carried out at the Department of Haematology at PNS SHIFA Hospital, Karachi, from November 2021 to October 2022. Seventy children with XDR S. Typhi on blood culture were selected using a consecutive sampling technique. The study focused on haematological parameters, i.e., haemoglobin (Hb), WBC count, and platelet count. Descriptive statistics were expressed as mean ±SD, and the Chi-square test was applied. A p-value ≤0.05 was considered statistically significant. RESULTS: Out of the total of 70 children (under 12 years of age) included in the study, 41 (58.6%) were male and 29 (41.4%) were female. The mean age was 8.17±2.92 years. Anaemia was observed in 51% percent of cases. Leucopenia and thrombocytopenia were noted in 44% and 54% of cases. Seventeen children had bicytopenia, while pancytopenia was seen in only two children. CONCLUSION: XDR S. Typhi infection causes significant cytopenias. Therefore, patients with a history of sustained fever with cytopenias should be worked up for possible XDR S. Typhi infection.xdr salmonella typhidrug-resistant s. typhihigh-grade feverthrombocytopenialeukopenia |
| spellingShingle | Nazish Tahir Saeed Akhtar Khan Khattak Nighat Jamal Ghulam Murtaza Shaikh Rabia Ahme Waleed Ahmed Haematological Manifestations in Children with Extended Drug-Resistant Salmonella Typhi Infections in a Tertiary Care Hospital JLUMHS xdr salmonella typhi drug-resistant s. typhi high-grade fever thrombocytopenia leukopenia |
| title | Haematological Manifestations in Children with Extended Drug-Resistant Salmonella Typhi Infections in a Tertiary Care Hospital |
| title_full | Haematological Manifestations in Children with Extended Drug-Resistant Salmonella Typhi Infections in a Tertiary Care Hospital |
| title_fullStr | Haematological Manifestations in Children with Extended Drug-Resistant Salmonella Typhi Infections in a Tertiary Care Hospital |
| title_full_unstemmed | Haematological Manifestations in Children with Extended Drug-Resistant Salmonella Typhi Infections in a Tertiary Care Hospital |
| title_short | Haematological Manifestations in Children with Extended Drug-Resistant Salmonella Typhi Infections in a Tertiary Care Hospital |
| title_sort | haematological manifestations in children with extended drug resistant salmonella typhi infections in a tertiary care hospital |
| topic | xdr salmonella typhi drug-resistant s. typhi high-grade fever thrombocytopenia leukopenia |
| work_keys_str_mv | AT nazishtahir haematologicalmanifestationsinchildrenwithextendeddrugresistantsalmonellatyphiinfectionsinatertiarycarehospital AT saeedakhtarkhankhattak haematologicalmanifestationsinchildrenwithextendeddrugresistantsalmonellatyphiinfectionsinatertiarycarehospital AT nighatjamal haematologicalmanifestationsinchildrenwithextendeddrugresistantsalmonellatyphiinfectionsinatertiarycarehospital AT ghulammurtazashaikh haematologicalmanifestationsinchildrenwithextendeddrugresistantsalmonellatyphiinfectionsinatertiarycarehospital AT rabiaahme haematologicalmanifestationsinchildrenwithextendeddrugresistantsalmonellatyphiinfectionsinatertiarycarehospital AT waleedahmed haematologicalmanifestationsinchildrenwithextendeddrugresistantsalmonellatyphiinfectionsinatertiarycarehospital |