Neuroinflammation: An Integrating Overview of Reactive-Neuroimmune Cell Interactions in Health and Disease
The concept of central nervous system (CNS) inflammation has evolved over the last decades. Neuroinflammation is the response of reactive CNS components to altered homeostasis, regardless of the cause to be endogenous or exogenous. Neurological diseases, whether traumatic, neoplastic, ischemic, meta...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/9999146 |
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| author | Rodolfo Kölliker-Frers Lucas Udovin Matilde Otero-Losada Tamara Kobiec María Inés Herrera Jorge Palacios Gabriela Razzitte Francisco Capani |
| author_facet | Rodolfo Kölliker-Frers Lucas Udovin Matilde Otero-Losada Tamara Kobiec María Inés Herrera Jorge Palacios Gabriela Razzitte Francisco Capani |
| author_sort | Rodolfo Kölliker-Frers |
| collection | DOAJ |
| description | The concept of central nervous system (CNS) inflammation has evolved over the last decades. Neuroinflammation is the response of reactive CNS components to altered homeostasis, regardless of the cause to be endogenous or exogenous. Neurological diseases, whether traumatic, neoplastic, ischemic, metabolic, toxic, infectious, autoimmune, developmental, or degenerative, involve direct and indirect immune-related neuroinflammation. Brain infiltrates of the innate and adaptive immune system cells appear in response to an infective or otherwise noxious agent and produce inflammatory mediators. Mediators of inflammation include local and recruited cells and signals. Processes derived from extrinsic and intrinsic CNS diseases also elicit the CNS inflammatory response. A deeper understanding of immune-related inflammation in health and disease is necessary to find potential therapeutic targets for preventing or reducing CNS damage. This review is aimed at discussing the innate and adaptive immune system functions and their roles in regulating brain cell responses in disease and homeostasis maintenance. |
| format | Article |
| id | doaj-art-8323c7b975374877a7148ab05c3d73c8 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8323c7b975374877a7148ab05c3d73c82025-08-20T03:37:37ZengWileyMediators of Inflammation0962-93511466-18612021-01-01202110.1155/2021/99991469999146Neuroinflammation: An Integrating Overview of Reactive-Neuroimmune Cell Interactions in Health and DiseaseRodolfo Kölliker-Frers0Lucas Udovin1Matilde Otero-Losada2Tamara Kobiec3María Inés Herrera4Jorge Palacios5Gabriela Razzitte6Francisco Capani7Centro de Altos Estudios en Ciencias Humanas y de la Salud, Universidad Abierta Interamericana–Consejo Nacional de Investigaciones Científicas y Técnicas, CAECIHS, UAI-CONICET, Buenos Aires, ArgentinaCentro de Altos Estudios en Ciencias Humanas y de la Salud, Universidad Abierta Interamericana–Consejo Nacional de Investigaciones Científicas y Técnicas, CAECIHS, UAI-CONICET, Buenos Aires, ArgentinaCentro de Altos Estudios en Ciencias Humanas y de la Salud, Universidad Abierta Interamericana–Consejo Nacional de Investigaciones Científicas y Técnicas, CAECIHS, UAI-CONICET, Buenos Aires, ArgentinaCentro de Altos Estudios en Ciencias Humanas y de la Salud, Universidad Abierta Interamericana–Consejo Nacional de Investigaciones Científicas y Técnicas, CAECIHS, UAI-CONICET, Buenos Aires, ArgentinaCentro de Altos Estudios en Ciencias Humanas y de la Salud, Universidad Abierta Interamericana–Consejo Nacional de Investigaciones Científicas y Técnicas, CAECIHS, UAI-CONICET, Buenos Aires, ArgentinaHospital de Agudos JM Ramos Mejía, Buenos Aires, ArgentinaHospital de Agudos JM Ramos Mejía, Buenos Aires, ArgentinaCentro de Altos Estudios en Ciencias Humanas y de la Salud, Universidad Abierta Interamericana–Consejo Nacional de Investigaciones Científicas y Técnicas, CAECIHS, UAI-CONICET, Buenos Aires, ArgentinaThe concept of central nervous system (CNS) inflammation has evolved over the last decades. Neuroinflammation is the response of reactive CNS components to altered homeostasis, regardless of the cause to be endogenous or exogenous. Neurological diseases, whether traumatic, neoplastic, ischemic, metabolic, toxic, infectious, autoimmune, developmental, or degenerative, involve direct and indirect immune-related neuroinflammation. Brain infiltrates of the innate and adaptive immune system cells appear in response to an infective or otherwise noxious agent and produce inflammatory mediators. Mediators of inflammation include local and recruited cells and signals. Processes derived from extrinsic and intrinsic CNS diseases also elicit the CNS inflammatory response. A deeper understanding of immune-related inflammation in health and disease is necessary to find potential therapeutic targets for preventing or reducing CNS damage. This review is aimed at discussing the innate and adaptive immune system functions and their roles in regulating brain cell responses in disease and homeostasis maintenance.http://dx.doi.org/10.1155/2021/9999146 |
| spellingShingle | Rodolfo Kölliker-Frers Lucas Udovin Matilde Otero-Losada Tamara Kobiec María Inés Herrera Jorge Palacios Gabriela Razzitte Francisco Capani Neuroinflammation: An Integrating Overview of Reactive-Neuroimmune Cell Interactions in Health and Disease Mediators of Inflammation |
| title | Neuroinflammation: An Integrating Overview of Reactive-Neuroimmune Cell Interactions in Health and Disease |
| title_full | Neuroinflammation: An Integrating Overview of Reactive-Neuroimmune Cell Interactions in Health and Disease |
| title_fullStr | Neuroinflammation: An Integrating Overview of Reactive-Neuroimmune Cell Interactions in Health and Disease |
| title_full_unstemmed | Neuroinflammation: An Integrating Overview of Reactive-Neuroimmune Cell Interactions in Health and Disease |
| title_short | Neuroinflammation: An Integrating Overview of Reactive-Neuroimmune Cell Interactions in Health and Disease |
| title_sort | neuroinflammation an integrating overview of reactive neuroimmune cell interactions in health and disease |
| url | http://dx.doi.org/10.1155/2021/9999146 |
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