Elevated Levels of Cerebrospinal Fluid and Plasma Interleukin-37 in Patients with Guillain-Barré Syndrome
Aims. Interleukin-37 (IL-37) is an anti-inflammatory cytokine. This study aims to investigate the concentrations of plasma and cerebrospinal fluid (CSF) IL-37 in patients with Guillain-Barré Syndrome (GBS). Methods. The levels of plasma and CSF IL-37, IL-17A, IFN-γ, and TNF-α in 25 GBS patients and...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/639712 |
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| author | Cong Li Pingwei Zhao Xiguang Sun Yuanyuan Che Yanfang Jiang |
| author_facet | Cong Li Pingwei Zhao Xiguang Sun Yuanyuan Che Yanfang Jiang |
| author_sort | Cong Li |
| collection | DOAJ |
| description | Aims. Interleukin-37 (IL-37) is an anti-inflammatory cytokine. This study aims to investigate the concentrations of plasma and cerebrospinal fluid (CSF) IL-37 in patients with Guillain-Barré Syndrome (GBS). Methods. The levels of plasma and CSF IL-37, IL-17A, IFN-γ, and TNF-α in 25 GBS patients and 20 healthy controls (HC) were determined by enzyme-linked immunoabsorbent assay and flow cytometric bead array assay, respectively. The values of clinical parameters in the patients were also measured. Results. The concentrations of plasma IL-37, IL-17A, IFN-γ, and TNF-α and CSF IL-37 and IL-17A in patients at the acute phase of GBS were significantly higher than those in the HC. The levels of plasma IL-37, IL-17A, IFN-γ, and TNF-α were positively correlated in those patients, and the levels of CSF IL-37 and IL-17A as well as the levels of plasma TNF-α were correlated positively with the GBS disability scale scores (GDSs) in those patients. Treatment with intravenous immunoglobulin significantly reduced the levels of plasma IL-37, IL-17A, IFN-γ, and TNF-α in the drug-responding patients. Conclusions. Our findings indicate higher levels of plasma and CSF IL-37 and IL-17A and other proinflammatory cytokines in patients with GBS. |
| format | Article |
| id | doaj-art-8322033dba2d44b59d9b0586282b8fc8 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8322033dba2d44b59d9b0586282b8fc82025-08-20T02:09:00ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/639712639712Elevated Levels of Cerebrospinal Fluid and Plasma Interleukin-37 in Patients with Guillain-Barré SyndromeCong Li0Pingwei Zhao1Xiguang Sun2Yuanyuan Che3Yanfang Jiang4Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, The Second Part of First Hospital, Jilin University, Changchun 130032, ChinaKey Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, The Second Part of First Hospital, Jilin University, Changchun 130032, ChinaKey Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, The Second Part of First Hospital, Jilin University, Changchun 130032, ChinaKey Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, The Second Part of First Hospital, Jilin University, Changchun 130032, ChinaKey Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, The Second Part of First Hospital, Jilin University, Changchun 130032, ChinaAims. Interleukin-37 (IL-37) is an anti-inflammatory cytokine. This study aims to investigate the concentrations of plasma and cerebrospinal fluid (CSF) IL-37 in patients with Guillain-Barré Syndrome (GBS). Methods. The levels of plasma and CSF IL-37, IL-17A, IFN-γ, and TNF-α in 25 GBS patients and 20 healthy controls (HC) were determined by enzyme-linked immunoabsorbent assay and flow cytometric bead array assay, respectively. The values of clinical parameters in the patients were also measured. Results. The concentrations of plasma IL-37, IL-17A, IFN-γ, and TNF-α and CSF IL-37 and IL-17A in patients at the acute phase of GBS were significantly higher than those in the HC. The levels of plasma IL-37, IL-17A, IFN-γ, and TNF-α were positively correlated in those patients, and the levels of CSF IL-37 and IL-17A as well as the levels of plasma TNF-α were correlated positively with the GBS disability scale scores (GDSs) in those patients. Treatment with intravenous immunoglobulin significantly reduced the levels of plasma IL-37, IL-17A, IFN-γ, and TNF-α in the drug-responding patients. Conclusions. Our findings indicate higher levels of plasma and CSF IL-37 and IL-17A and other proinflammatory cytokines in patients with GBS.http://dx.doi.org/10.1155/2013/639712 |
| spellingShingle | Cong Li Pingwei Zhao Xiguang Sun Yuanyuan Che Yanfang Jiang Elevated Levels of Cerebrospinal Fluid and Plasma Interleukin-37 in Patients with Guillain-Barré Syndrome Mediators of Inflammation |
| title | Elevated Levels of Cerebrospinal Fluid and Plasma Interleukin-37 in Patients with Guillain-Barré Syndrome |
| title_full | Elevated Levels of Cerebrospinal Fluid and Plasma Interleukin-37 in Patients with Guillain-Barré Syndrome |
| title_fullStr | Elevated Levels of Cerebrospinal Fluid and Plasma Interleukin-37 in Patients with Guillain-Barré Syndrome |
| title_full_unstemmed | Elevated Levels of Cerebrospinal Fluid and Plasma Interleukin-37 in Patients with Guillain-Barré Syndrome |
| title_short | Elevated Levels of Cerebrospinal Fluid and Plasma Interleukin-37 in Patients with Guillain-Barré Syndrome |
| title_sort | elevated levels of cerebrospinal fluid and plasma interleukin 37 in patients with guillain barre syndrome |
| url | http://dx.doi.org/10.1155/2013/639712 |
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