The potential of miR-29 in modulating tumor angiogenesis: a comprehensive review
Abstract MicroRNAs (miRNAs) are a class of short non-coding RNAs that play a crucial role in the post-transcriptional regulation of gene expression. They are associated with various biological processes related to tumors. Among the numerous miRNAs, miR-29 has garnered attention for its role in regul...
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| Format: | Article |
| Language: | English |
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Springer
2025-04-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-02246-3 |
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| author | Rui-Ting Zhou Xiao-Jie Luo Xiao-Xin-Ran Zhang Jiang-Feng Wu Yi-Ran Ni |
| author_facet | Rui-Ting Zhou Xiao-Jie Luo Xiao-Xin-Ran Zhang Jiang-Feng Wu Yi-Ran Ni |
| author_sort | Rui-Ting Zhou |
| collection | DOAJ |
| description | Abstract MicroRNAs (miRNAs) are a class of short non-coding RNAs that play a crucial role in the post-transcriptional regulation of gene expression. They are associated with various biological processes related to tumors. Among the numerous miRNAs, miR-29 has garnered attention for its role in regulating tumor angiogenesis. In numerous human tumors, miR-29 has been demonstrated to negatively correlate with the capacity for angiogenesis and the degree of malignancy, as well as with the expression levels of pro-angiogenic factors such as vascular endothelial growth factor vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and matrix metalloproteinase (MMP)-2. Multiple studies, utilizing techniques like dual-luciferase reporter assays, have confirmed that miR-29 directly targets the 3'-untranslated region (UTR) of mRNAs for VEGF, PDGF, and MMP-2. Extensive investigations involving tumor cell lines and animal models have shown that the overexpression of miR-29, achieved through miRNA transfection or the introduction of miRNA mimics, effectively inhibits angiogenesis by upregulating these pro-angiogenic factors. Conversely, downregulation of miR-29 using specific inhibitors promotes angiogenesis. While small molecule inhibitors and antibodies targeting VEGF constitute a primary strategy in anti-angiogenesis therapies, miR-29's ability to target multiple pro-angiogenic molecules positions it as a promising candidate for future therapeutic interventions, especially with ongoing advancements in nucleic acid drug design and delivery systems. |
| format | Article |
| id | doaj-art-831cfe94c26d4ddeaa0361e57763a6f3 |
| institution | DOAJ |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-831cfe94c26d4ddeaa0361e57763a6f32025-08-20T03:10:07ZengSpringerDiscover Oncology2730-60112025-04-0116111110.1007/s12672-025-02246-3The potential of miR-29 in modulating tumor angiogenesis: a comprehensive reviewRui-Ting Zhou0Xiao-Jie Luo1Xiao-Xin-Ran Zhang2Jiang-Feng Wu3Yi-Ran Ni4Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges UniversityHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges UniversityHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges UniversityHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges UniversityHubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges UniversityAbstract MicroRNAs (miRNAs) are a class of short non-coding RNAs that play a crucial role in the post-transcriptional regulation of gene expression. They are associated with various biological processes related to tumors. Among the numerous miRNAs, miR-29 has garnered attention for its role in regulating tumor angiogenesis. In numerous human tumors, miR-29 has been demonstrated to negatively correlate with the capacity for angiogenesis and the degree of malignancy, as well as with the expression levels of pro-angiogenic factors such as vascular endothelial growth factor vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and matrix metalloproteinase (MMP)-2. Multiple studies, utilizing techniques like dual-luciferase reporter assays, have confirmed that miR-29 directly targets the 3'-untranslated region (UTR) of mRNAs for VEGF, PDGF, and MMP-2. Extensive investigations involving tumor cell lines and animal models have shown that the overexpression of miR-29, achieved through miRNA transfection or the introduction of miRNA mimics, effectively inhibits angiogenesis by upregulating these pro-angiogenic factors. Conversely, downregulation of miR-29 using specific inhibitors promotes angiogenesis. While small molecule inhibitors and antibodies targeting VEGF constitute a primary strategy in anti-angiogenesis therapies, miR-29's ability to target multiple pro-angiogenic molecules positions it as a promising candidate for future therapeutic interventions, especially with ongoing advancements in nucleic acid drug design and delivery systems.https://doi.org/10.1007/s12672-025-02246-3AngiogenesismiR-29Vascular endothelial growth factorClinical application |
| spellingShingle | Rui-Ting Zhou Xiao-Jie Luo Xiao-Xin-Ran Zhang Jiang-Feng Wu Yi-Ran Ni The potential of miR-29 in modulating tumor angiogenesis: a comprehensive review Discover Oncology Angiogenesis miR-29 Vascular endothelial growth factor Clinical application |
| title | The potential of miR-29 in modulating tumor angiogenesis: a comprehensive review |
| title_full | The potential of miR-29 in modulating tumor angiogenesis: a comprehensive review |
| title_fullStr | The potential of miR-29 in modulating tumor angiogenesis: a comprehensive review |
| title_full_unstemmed | The potential of miR-29 in modulating tumor angiogenesis: a comprehensive review |
| title_short | The potential of miR-29 in modulating tumor angiogenesis: a comprehensive review |
| title_sort | potential of mir 29 in modulating tumor angiogenesis a comprehensive review |
| topic | Angiogenesis miR-29 Vascular endothelial growth factor Clinical application |
| url | https://doi.org/10.1007/s12672-025-02246-3 |
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