Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature
Proton pump inhibitors (PPIs) are the most effective and preferred class of drugs used to treat peptic ulcer disease, gastroesophageal reflux disease, and other diseases associated with increased production of gastric acid. PPIs in general have an excellent long-term safety profile and are well-tole...
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| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/4294805 |
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| author | Subhajit Mukherjee Tanima Jana Jen-Jung Pan |
| author_facet | Subhajit Mukherjee Tanima Jana Jen-Jung Pan |
| author_sort | Subhajit Mukherjee |
| collection | DOAJ |
| description | Proton pump inhibitors (PPIs) are the most effective and preferred class of drugs used to treat peptic ulcer disease, gastroesophageal reflux disease, and other diseases associated with increased production of gastric acid. PPIs in general have an excellent long-term safety profile and are well-tolerated. However, studies have shown some adverse reactions (e.g., osteoporosis, Clostridium difficile-associated diarrhea, Vitamin B12 and iron deficiency, and acute interstitial nephritis) on long-term PPI use. Thrombocytopenia attributed to use of PPIs has been described in a few case reports and a retrospective study. In this case report, we describe a case of PPI-induced thrombocytopenia. In our patient, thrombocytopenia immediately developed after the initiation of PPI on two separate occasions and resolved after its discontinuation. The strong association found in our case implies the potential role of PPI in causing this rare but serious adverse reaction. Based on this case report and the observation from other studies, a PPI-induced adverse event should be considered as a possible etiology for new-onset idiopathic thrombocytopenia. |
| format | Article |
| id | doaj-art-831ae0d9af4945728136f2a4c884d5cf |
| institution | Kabale University |
| issn | 2090-6528 2090-6536 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-831ae0d9af4945728136f2a4c884d5cf2025-02-03T01:13:12ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362018-01-01201810.1155/2018/42948054294805Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the LiteratureSubhajit Mukherjee0Tanima Jana1Jen-Jung Pan2Division of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, The University of Texas Health Science Center, Houston, TX 77030, USADivision of Gastroenterology, Hepatology and Nutrition, Department of Internal Medicine, The University of Texas Health Science Center, Houston, TX 77030, USADivision of Gastroenterology and Hepatology, Department of Medicine, University of Arizona College of Medicine, Tucson, AZ 85724, USAProton pump inhibitors (PPIs) are the most effective and preferred class of drugs used to treat peptic ulcer disease, gastroesophageal reflux disease, and other diseases associated with increased production of gastric acid. PPIs in general have an excellent long-term safety profile and are well-tolerated. However, studies have shown some adverse reactions (e.g., osteoporosis, Clostridium difficile-associated diarrhea, Vitamin B12 and iron deficiency, and acute interstitial nephritis) on long-term PPI use. Thrombocytopenia attributed to use of PPIs has been described in a few case reports and a retrospective study. In this case report, we describe a case of PPI-induced thrombocytopenia. In our patient, thrombocytopenia immediately developed after the initiation of PPI on two separate occasions and resolved after its discontinuation. The strong association found in our case implies the potential role of PPI in causing this rare but serious adverse reaction. Based on this case report and the observation from other studies, a PPI-induced adverse event should be considered as a possible etiology for new-onset idiopathic thrombocytopenia.http://dx.doi.org/10.1155/2018/4294805 |
| spellingShingle | Subhajit Mukherjee Tanima Jana Jen-Jung Pan Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature Case Reports in Gastrointestinal Medicine |
| title | Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature |
| title_full | Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature |
| title_fullStr | Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature |
| title_full_unstemmed | Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature |
| title_short | Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature |
| title_sort | adverse effects of proton pump inhibitors on platelet count a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2018/4294805 |
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