<i>Bacillus clausii</i> Attenuates 5-Fluorouracil-Induced Intestinal Mucositis in Mice
5-Fluorouracil (5-FU) is an antimetabolite widely prescribed in cancer treatments, but its use in highly proliferative tissues can cause significant problems such as mucositis. <i>Bacillus clausii</i> is a probiotic commonly used for protection against acute diarrhea, gastrointestinal dy...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/17/12/1676 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850239432796405760 |
|---|---|
| author | Francisco Ronaldo Farias Lima Carlos Eduardo da Silva Monteiro Samara Rodrigues Bonfim Damasceno Patricia da Silva Pantoja Álvaro Xavier Franco Renan Oliveira Silva Johnatan Alisson Oliveira Sousa Tiago Santos Mendes Marcos Aurélio Lima Priscilla Fernanda Campos Justino Marcellus Henrique Loiola Ponte de Souza Pedro Marcos Gomes Soares |
| author_facet | Francisco Ronaldo Farias Lima Carlos Eduardo da Silva Monteiro Samara Rodrigues Bonfim Damasceno Patricia da Silva Pantoja Álvaro Xavier Franco Renan Oliveira Silva Johnatan Alisson Oliveira Sousa Tiago Santos Mendes Marcos Aurélio Lima Priscilla Fernanda Campos Justino Marcellus Henrique Loiola Ponte de Souza Pedro Marcos Gomes Soares |
| author_sort | Francisco Ronaldo Farias Lima |
| collection | DOAJ |
| description | 5-Fluorouracil (5-FU) is an antimetabolite widely prescribed in cancer treatments, but its use in highly proliferative tissues can cause significant problems such as mucositis. <i>Bacillus clausii</i> is a probiotic commonly used for protection against acute diarrhea, gastrointestinal dysbiosis and inflammatory bowel diseases. We investigated the effect of <i>B. clausii</i> on 5-FU intestinal mucositis in mice. <i>B. clausii</i> was administered concomitantly with 5-FU on the first day and alone for the other two days. After the third day of 5-FU (450 mg/kg, ip), the animals were euthanized. Ileum samples were removed for evaluation for histopathological and biochemical analyses (myeloperoxidase (MPO), glutathione (GSH), malondialdehyde (MDA), catalase (CAT), interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α). In addition, we investigated gastric emptying and intestinal transit, intestinal permeability, intestinal smooth muscle contractility, transepithelial electrical resistance and intestinal transport of water and electrolytes. <i>B. clausii</i> reduced histopathological scores and increased the villus/crypt ratio in all intestinal segments after mucositis. <i>B. clausii</i> attenuated 5-FU-induced weight loss. The probiotic treatment increased GSH levels, reduced MPO and CAT activity, and also reduced MDA, IL-1β and TNF-α levels. <i>B. clausii</i> attenuated the delay in gastric emptying, water and electrolyte secretion and intestinal hypercontractility, and increased 5-FU-induced intestinal permeability. Thus, our data suggest that <i>B. clausii</i> may be a potential candidate for the treatment of chemotherapy-induced intestinal mucositis. |
| format | Article |
| id | doaj-art-8318cc7ab04f42f2bbc690648e895653 |
| institution | OA Journals |
| issn | 1424-8247 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj-art-8318cc7ab04f42f2bbc690648e8956532025-08-20T02:01:09ZengMDPI AGPharmaceuticals1424-82472024-12-011712167610.3390/ph17121676<i>Bacillus clausii</i> Attenuates 5-Fluorouracil-Induced Intestinal Mucositis in MiceFrancisco Ronaldo Farias Lima0Carlos Eduardo da Silva Monteiro1Samara Rodrigues Bonfim Damasceno2Patricia da Silva Pantoja3Álvaro Xavier Franco4Renan Oliveira Silva5Johnatan Alisson Oliveira Sousa6Tiago Santos Mendes7Marcos Aurélio Lima8Priscilla Fernanda Campos Justino9Marcellus Henrique Loiola Ponte de Souza10Pedro Marcos Gomes Soares11Laboratory of Gastrointestinal Physio-Pharmacology (LEFFAG), Federal University of Ceará, Coronel Nunes de Melo Street, 1315 Rodolfo Teófilo, Fortaleza 60416-030, CE, BrazilLaboratory of Gastrointestinal Physio-Pharmacology (LEFFAG), Federal University of Ceará, Coronel Nunes de Melo Street, 1315 Rodolfo Teófilo, Fortaleza 60416-030, CE, BrazilLaboratory of Gastrointestinal Physio-Pharmacology (LEFFAG), Federal University of Ceará, Coronel Nunes de Melo Street, 1315 Rodolfo Teófilo, Fortaleza 60416-030, CE, BrazilLaboratory of Gastrointestinal Physio-Pharmacology (LEFFAG), Federal University of Ceará, Coronel Nunes de Melo Street, 1315 Rodolfo Teófilo, Fortaleza 60416-030, CE, BrazilLaboratory of Gastrointestinal Physio-Pharmacology (LEFFAG), Federal University of Ceará, Coronel Nunes de Melo Street, 1315 Rodolfo Teófilo, Fortaleza 60416-030, CE, BrazilDepartment of Physiology and Pharmacology, Federal University of Pernambuco, Av. da Engenharia-Cidade Universitária, Recife 50670-420, PE, BrazilLaboratory of Gastrointestinal Physio-Pharmacology (LEFFAG), Federal University of Ceará, Coronel Nunes de Melo Street, 1315 Rodolfo Teófilo, Fortaleza 60416-030, CE, BrazilLaboratory of Gastrointestinal Physio-Pharmacology (LEFFAG), Federal University of Ceará, Coronel Nunes de Melo Street, 1315 Rodolfo Teófilo, Fortaleza 60416-030, CE, BrazilLaboratory of Gastrointestinal Physio-Pharmacology (LEFFAG), Federal University of Ceará, Coronel Nunes de Melo Street, 1315 Rodolfo Teófilo, Fortaleza 60416-030, CE, BrazilLaboratory of Gastrointestinal Physio-Pharmacology (LEFFAG), Federal University of Ceará, Coronel Nunes de Melo Street, 1315 Rodolfo Teófilo, Fortaleza 60416-030, CE, BrazilLaboratory of Gastrointestinal Physio-Pharmacology (LEFFAG), Federal University of Ceará, Coronel Nunes de Melo Street, 1315 Rodolfo Teófilo, Fortaleza 60416-030, CE, BrazilLaboratory of Gastrointestinal Physio-Pharmacology (LEFFAG), Federal University of Ceará, Coronel Nunes de Melo Street, 1315 Rodolfo Teófilo, Fortaleza 60416-030, CE, Brazil5-Fluorouracil (5-FU) is an antimetabolite widely prescribed in cancer treatments, but its use in highly proliferative tissues can cause significant problems such as mucositis. <i>Bacillus clausii</i> is a probiotic commonly used for protection against acute diarrhea, gastrointestinal dysbiosis and inflammatory bowel diseases. We investigated the effect of <i>B. clausii</i> on 5-FU intestinal mucositis in mice. <i>B. clausii</i> was administered concomitantly with 5-FU on the first day and alone for the other two days. After the third day of 5-FU (450 mg/kg, ip), the animals were euthanized. Ileum samples were removed for evaluation for histopathological and biochemical analyses (myeloperoxidase (MPO), glutathione (GSH), malondialdehyde (MDA), catalase (CAT), interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α). In addition, we investigated gastric emptying and intestinal transit, intestinal permeability, intestinal smooth muscle contractility, transepithelial electrical resistance and intestinal transport of water and electrolytes. <i>B. clausii</i> reduced histopathological scores and increased the villus/crypt ratio in all intestinal segments after mucositis. <i>B. clausii</i> attenuated 5-FU-induced weight loss. The probiotic treatment increased GSH levels, reduced MPO and CAT activity, and also reduced MDA, IL-1β and TNF-α levels. <i>B. clausii</i> attenuated the delay in gastric emptying, water and electrolyte secretion and intestinal hypercontractility, and increased 5-FU-induced intestinal permeability. Thus, our data suggest that <i>B. clausii</i> may be a potential candidate for the treatment of chemotherapy-induced intestinal mucositis.https://www.mdpi.com/1424-8247/17/12/1676probioticmucositis5-fluorouracil<i>Bacillus clausii</i>chemotherapy |
| spellingShingle | Francisco Ronaldo Farias Lima Carlos Eduardo da Silva Monteiro Samara Rodrigues Bonfim Damasceno Patricia da Silva Pantoja Álvaro Xavier Franco Renan Oliveira Silva Johnatan Alisson Oliveira Sousa Tiago Santos Mendes Marcos Aurélio Lima Priscilla Fernanda Campos Justino Marcellus Henrique Loiola Ponte de Souza Pedro Marcos Gomes Soares <i>Bacillus clausii</i> Attenuates 5-Fluorouracil-Induced Intestinal Mucositis in Mice Pharmaceuticals probiotic mucositis 5-fluorouracil <i>Bacillus clausii</i> chemotherapy |
| title | <i>Bacillus clausii</i> Attenuates 5-Fluorouracil-Induced Intestinal Mucositis in Mice |
| title_full | <i>Bacillus clausii</i> Attenuates 5-Fluorouracil-Induced Intestinal Mucositis in Mice |
| title_fullStr | <i>Bacillus clausii</i> Attenuates 5-Fluorouracil-Induced Intestinal Mucositis in Mice |
| title_full_unstemmed | <i>Bacillus clausii</i> Attenuates 5-Fluorouracil-Induced Intestinal Mucositis in Mice |
| title_short | <i>Bacillus clausii</i> Attenuates 5-Fluorouracil-Induced Intestinal Mucositis in Mice |
| title_sort | i bacillus clausii i attenuates 5 fluorouracil induced intestinal mucositis in mice |
| topic | probiotic mucositis 5-fluorouracil <i>Bacillus clausii</i> chemotherapy |
| url | https://www.mdpi.com/1424-8247/17/12/1676 |
| work_keys_str_mv | AT franciscoronaldofariaslima ibacillusclausiiiattenuates5fluorouracilinducedintestinalmucositisinmice AT carloseduardodasilvamonteiro ibacillusclausiiiattenuates5fluorouracilinducedintestinalmucositisinmice AT samararodriguesbonfimdamasceno ibacillusclausiiiattenuates5fluorouracilinducedintestinalmucositisinmice AT patriciadasilvapantoja ibacillusclausiiiattenuates5fluorouracilinducedintestinalmucositisinmice AT alvaroxavierfranco ibacillusclausiiiattenuates5fluorouracilinducedintestinalmucositisinmice AT renanoliveirasilva ibacillusclausiiiattenuates5fluorouracilinducedintestinalmucositisinmice AT johnatanalissonoliveirasousa ibacillusclausiiiattenuates5fluorouracilinducedintestinalmucositisinmice AT tiagosantosmendes ibacillusclausiiiattenuates5fluorouracilinducedintestinalmucositisinmice AT marcosaureliolima ibacillusclausiiiattenuates5fluorouracilinducedintestinalmucositisinmice AT priscillafernandacamposjustino ibacillusclausiiiattenuates5fluorouracilinducedintestinalmucositisinmice AT marcellushenriqueloiolapontedesouza ibacillusclausiiiattenuates5fluorouracilinducedintestinalmucositisinmice AT pedromarcosgomessoares ibacillusclausiiiattenuates5fluorouracilinducedintestinalmucositisinmice |