A concise review on copper catalyzed synthesis of α-ketoamides
The α-ketoamides are essential building blocks for the synthesis of β-lactams and oxazolidinones. As it contains multiple reactive centers, it could be a suitable starting material for following reactions such as Michael addition reaction, Pictet–Spengler reaction, Mannich, Stetter reaction etc. The...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-05-01
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| Series: | Applied Catalysis O: Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950648425000148 |
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| Summary: | The α-ketoamides are essential building blocks for the synthesis of β-lactams and oxazolidinones. As it contains multiple reactive centers, it could be a suitable starting material for following reactions such as Michael addition reaction, Pictet–Spengler reaction, Mannich, Stetter reaction etc. The familiar US FDA approved drug molecules bearing α-ketoamide moieties are boceprevir, telaprevir, fostemsavir, and varespladib. This review describes the research articles (since the year 2012) related copper-catalyzed α-ketoamides synthesis and mechanism of those reactions. Copper-catalyzed synthesis of α-ketoamides from aryl methyl ketones, aryl acetic acids, alkynes, aryl acetaldehydes, α-keto acids, α-azido ketones, and 1,3-diketo compounds have been discussed. |
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| ISSN: | 2950-6484 |