Brown fat thermogenesis and cold adaptation in humans
Abstract Brown adipose tissue (BAT) is a site of non-shivering thermogenesis (NST) in mammals. Since the rediscovery of BAT in adult humans, there has been a remarkable advance in human BAT researches, revealing the significant roles of this thermogenic tissue in cold-induced NST and cold adaptation...
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | Journal of Physiological Anthropology |
| Online Access: | https://doi.org/10.1186/s40101-025-00391-w |
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| author | Takeshi Yoneshiro Mami Matsushita Juro Sakai Masayuki Saito |
| author_facet | Takeshi Yoneshiro Mami Matsushita Juro Sakai Masayuki Saito |
| author_sort | Takeshi Yoneshiro |
| collection | DOAJ |
| description | Abstract Brown adipose tissue (BAT) is a site of non-shivering thermogenesis (NST) in mammals. Since the rediscovery of BAT in adult humans, there has been a remarkable advance in human BAT researches, revealing the significant roles of this thermogenic tissue in cold-induced NST and cold adaptation. Cold stress influences BAT in various time spans: acute cold exposure promptly activates BAT to induce NST, which contributes to immediate maintenance of body temperature. Prolonged cold exposure recruits BAT, resulting in increased capacity of NST and improved cold tolerance. Such BAT adaptation not only occurs in the exposed individual but also is passed on to the next generation, probably via the paternal lineage. As such, BAT plays a role in acute, chronic, and transgenerational adaptation to cold environment in humans. |
| format | Article |
| id | doaj-art-8311fce4eeee4a30b075cda087f073ed |
| institution | OA Journals |
| issn | 1880-6805 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Physiological Anthropology |
| spelling | doaj-art-8311fce4eeee4a30b075cda087f073ed2025-08-20T02:28:42ZengBMCJournal of Physiological Anthropology1880-68052025-04-014411910.1186/s40101-025-00391-wBrown fat thermogenesis and cold adaptation in humansTakeshi Yoneshiro0Mami Matsushita1Juro Sakai2Masayuki Saito3Division of Molecular Physiology and Metabolism, Tohoku University Graduate School of MedicineDepartment of Nutrition, School of Nursing and Nutrition, Tenshi CollegeDivision of Molecular Physiology and Metabolism, Tohoku University Graduate School of MedicineDepartment of Nutrition, School of Nursing and Nutrition, Tenshi CollegeAbstract Brown adipose tissue (BAT) is a site of non-shivering thermogenesis (NST) in mammals. Since the rediscovery of BAT in adult humans, there has been a remarkable advance in human BAT researches, revealing the significant roles of this thermogenic tissue in cold-induced NST and cold adaptation. Cold stress influences BAT in various time spans: acute cold exposure promptly activates BAT to induce NST, which contributes to immediate maintenance of body temperature. Prolonged cold exposure recruits BAT, resulting in increased capacity of NST and improved cold tolerance. Such BAT adaptation not only occurs in the exposed individual but also is passed on to the next generation, probably via the paternal lineage. As such, BAT plays a role in acute, chronic, and transgenerational adaptation to cold environment in humans.https://doi.org/10.1186/s40101-025-00391-w |
| spellingShingle | Takeshi Yoneshiro Mami Matsushita Juro Sakai Masayuki Saito Brown fat thermogenesis and cold adaptation in humans Journal of Physiological Anthropology |
| title | Brown fat thermogenesis and cold adaptation in humans |
| title_full | Brown fat thermogenesis and cold adaptation in humans |
| title_fullStr | Brown fat thermogenesis and cold adaptation in humans |
| title_full_unstemmed | Brown fat thermogenesis and cold adaptation in humans |
| title_short | Brown fat thermogenesis and cold adaptation in humans |
| title_sort | brown fat thermogenesis and cold adaptation in humans |
| url | https://doi.org/10.1186/s40101-025-00391-w |
| work_keys_str_mv | AT takeshiyoneshiro brownfatthermogenesisandcoldadaptationinhumans AT mamimatsushita brownfatthermogenesisandcoldadaptationinhumans AT jurosakai brownfatthermogenesisandcoldadaptationinhumans AT masayukisaito brownfatthermogenesisandcoldadaptationinhumans |