Beyond Peptides and Peptidomimetics: Natural Heteroaromatic Amino Acids in the Synthesis of Fused Heterocyclic Frameworks for Bioactive Agents
Heterocycle cores are widely used in medicinal chemistry for developing bioactive compounds. In this scenario, using cheap and accessible starting material to build these heterocycles is desirable to obtain new drug candidates for cost-efficient processes. One easily accessible source of starting ma...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-05-01
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| Series: | Organics |
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| Online Access: | https://www.mdpi.com/2673-401X/6/2/23 |
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| author | Isis Apolo Silveira de Borba Jamile Buligon Peripolli Angélica Rocha Joaquim Fernando Fumagalli |
| author_facet | Isis Apolo Silveira de Borba Jamile Buligon Peripolli Angélica Rocha Joaquim Fernando Fumagalli |
| author_sort | Isis Apolo Silveira de Borba |
| collection | DOAJ |
| description | Heterocycle cores are widely used in medicinal chemistry for developing bioactive compounds. In this scenario, using cheap and accessible starting material to build these heterocycles is desirable to obtain new drug candidates for cost-efficient processes. One easily accessible source of starting material are amino acids. Usually, these compounds are employed in peptide synthesis, but their use for building heterocycle frameworks presents another appealing opportunity. Therefore, this review highlights the application of histidine and tryptophan, two heteroaromatic amino acids, in fused heterocyclic scaffold synthesis and their use in bioactive compounds. |
| format | Article |
| id | doaj-art-830c8dc82bfb42ec824ebb63cb798422 |
| institution | DOAJ |
| issn | 2673-401X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Organics |
| spelling | doaj-art-830c8dc82bfb42ec824ebb63cb7984222025-08-20T03:16:21ZengMDPI AGOrganics2673-401X2025-05-01622310.3390/org6020023Beyond Peptides and Peptidomimetics: Natural Heteroaromatic Amino Acids in the Synthesis of Fused Heterocyclic Frameworks for Bioactive AgentsIsis Apolo Silveira de Borba0Jamile Buligon Peripolli1Angélica Rocha Joaquim2Fernando Fumagalli3Pharmaceutical Sciences Graduate Program, Federal University of Santa Maria, Santa Maria 97105-900, RS, BrazilPharmacy Course, Federal University of Santa Maria, Santa Maria 97105-900, RS, BrazilDepartment of Pharmacy, Health Sciences Centre (DFI/CCS), Federal University of Santa Maria, Santa Maria 97105-900, RS, BrazilDepartment of Pharmacy, Health Sciences Centre (DFI/CCS), Federal University of Santa Maria, Santa Maria 97105-900, RS, BrazilHeterocycle cores are widely used in medicinal chemistry for developing bioactive compounds. In this scenario, using cheap and accessible starting material to build these heterocycles is desirable to obtain new drug candidates for cost-efficient processes. One easily accessible source of starting material are amino acids. Usually, these compounds are employed in peptide synthesis, but their use for building heterocycle frameworks presents another appealing opportunity. Therefore, this review highlights the application of histidine and tryptophan, two heteroaromatic amino acids, in fused heterocyclic scaffold synthesis and their use in bioactive compounds.https://www.mdpi.com/2673-401X/6/2/23histidinetryptophanmedicinal chemistryheterocyclic core |
| spellingShingle | Isis Apolo Silveira de Borba Jamile Buligon Peripolli Angélica Rocha Joaquim Fernando Fumagalli Beyond Peptides and Peptidomimetics: Natural Heteroaromatic Amino Acids in the Synthesis of Fused Heterocyclic Frameworks for Bioactive Agents Organics histidine tryptophan medicinal chemistry heterocyclic core |
| title | Beyond Peptides and Peptidomimetics: Natural Heteroaromatic Amino Acids in the Synthesis of Fused Heterocyclic Frameworks for Bioactive Agents |
| title_full | Beyond Peptides and Peptidomimetics: Natural Heteroaromatic Amino Acids in the Synthesis of Fused Heterocyclic Frameworks for Bioactive Agents |
| title_fullStr | Beyond Peptides and Peptidomimetics: Natural Heteroaromatic Amino Acids in the Synthesis of Fused Heterocyclic Frameworks for Bioactive Agents |
| title_full_unstemmed | Beyond Peptides and Peptidomimetics: Natural Heteroaromatic Amino Acids in the Synthesis of Fused Heterocyclic Frameworks for Bioactive Agents |
| title_short | Beyond Peptides and Peptidomimetics: Natural Heteroaromatic Amino Acids in the Synthesis of Fused Heterocyclic Frameworks for Bioactive Agents |
| title_sort | beyond peptides and peptidomimetics natural heteroaromatic amino acids in the synthesis of fused heterocyclic frameworks for bioactive agents |
| topic | histidine tryptophan medicinal chemistry heterocyclic core |
| url | https://www.mdpi.com/2673-401X/6/2/23 |
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