Incidence, long-term predictors and progression of chronic kidney disease among African migrants and non-migrants: the transcontinental population-based prospective RODAM cohort study
Background Limited longitudinal data exist on chronic kidney disease (CKD) in African populations undergoing epidemiological transitions. We investigated incidence, long-term predictors and progression of CKD among Ghanaians residing in Ghana and Ghanaian migrants in the Netherlands (Amsterdam).Meth...
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BMJ Publishing Group
2025-01-01
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| Series: | BMJ Global Health |
| Online Access: | https://gh.bmj.com/content/10/1/e016786.full |
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| author | Charles Agyemang Ellis Owusu-Dabo Erik Beune Karlijn Meeks Bert-Jan H van den Born Liffert Vogt Felix P Chilunga Charles F Hayfron-Benjamin Sampson Twumasi-Ankrah Muhulo Muhau Mungamba Eva L van der Linden Engwa A Godwill Samuel N Darko Benedicta N Chungag |
| author_facet | Charles Agyemang Ellis Owusu-Dabo Erik Beune Karlijn Meeks Bert-Jan H van den Born Liffert Vogt Felix P Chilunga Charles F Hayfron-Benjamin Sampson Twumasi-Ankrah Muhulo Muhau Mungamba Eva L van der Linden Engwa A Godwill Samuel N Darko Benedicta N Chungag |
| author_sort | Charles Agyemang |
| collection | DOAJ |
| description | Background Limited longitudinal data exist on chronic kidney disease (CKD) in African populations undergoing epidemiological transitions. We investigated incidence, long-term predictors and progression of CKD among Ghanaians residing in Ghana and Ghanaian migrants in the Netherlands (Amsterdam).Methods and findings We analysed data from 2183 participants in the transcontinental population-based prospective Research on Obesity and Diabetes among African Migrants cohort, followed for approximately 7 years. CKD incidence and its progression to end-stage kidney disease (ESKD) were defined using Kidney Disease: Improving Global Outcomes (KDIGO) criteria. CKD incidence was calculated using age- and sex standardisation for those without CKD at baseline. Long-term predictors of CKD incidence were identified using one-step robust Poisson regression. CKD progression to ESKD from baseline was also assessed using robust Poisson regressions. Overall age- and sex standardised CKD incidence was 11.0% (95% CI 9.3% to 12.3%) in the population, with Ghanaians residing in Amsterdam at (7.6%; 5.7% to 9.5%) and Ghanaians residing in Ghana at (12.9%; 10.9% to 14.9%). Within Ghana, rural Ghanaians had similar CKD incidence to urban Ghanaians (12.5%; 8.5% to 15.5% vs 12.3%; 8.2% to 15.8%). Residence in Amsterdam was associated with lower CKD incidence compared with Ghana after adjustments (incidence rate ratio=0.32; 0.13–0.77). CKD incidence predictors were advanced age, female sex, alcohol consumption, uric acid levels and hypertension. CKD progression to ESKD was 2.3% among Ghanaians residing in Ghana and 0.0% among Ghanaians residing in Amsterdam.Conclusion One-tenth of Ghanaians developed CKD over 7 years, with higher incidence in Ghana compared with Europe. Age, female sex, alcohol use, uric acid levels and hypertension were predictive factors. CKD progression to ESKD was minimal. High CKD incidence among Ghanaians, especially those residing in Ghana, calls for in-depth assessment of contributing factors and targeted interventions. |
| format | Article |
| id | doaj-art-830664deed8b4bf5b38bf4eeae718b5a |
| institution | Kabale University |
| issn | 2059-7908 |
| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-830664deed8b4bf5b38bf4eeae718b5a2025-01-22T05:30:09ZengBMJ Publishing GroupBMJ Global Health2059-79082025-01-0110110.1136/bmjgh-2024-016786Incidence, long-term predictors and progression of chronic kidney disease among African migrants and non-migrants: the transcontinental population-based prospective RODAM cohort studyCharles Agyemang0Ellis Owusu-Dabo1Erik Beune2Karlijn Meeks3Bert-Jan H van den Born4Liffert Vogt5Felix P Chilunga6Charles F Hayfron-Benjamin7Sampson Twumasi-Ankrah8Muhulo Muhau Mungamba9Eva L van der Linden10Engwa A Godwill11Samuel N Darko12Benedicta N Chungag13Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USAKwame Nkrumah University of Science and Technology, Kumasi, GhanaDepartment of Public and Occupational Health, University of Amsterdam, Amsterdam, The NetherlandsDepartment of Public and Occupational Health, University of Amsterdam, Amsterdam, The NetherlandsDepartment of Vascular Medicine, University of Amsterdam, Amsterdam, The NetherlandsDepartment of Internal Medicine, University of Amsterdam, Amsterdam, The NetherlandsDepartment of Public and Occupational Health, University of Amsterdam, Amsterdam, The NetherlandsDepartment of Public and Occupational Health, University of Amsterdam, Amsterdam, The NetherlandsDepartment of Statistics and Actuarial Science, Kwame Nkrumah University of Science and Technology, Kumasi, GhanaPublic and Occupational Health, University of Amsterdam, Amsterdam, The NetherlandsDepartment of Public and Occupational Health, University of Amsterdam, Amsterdam, The NetherlandsDepartment of Biological and Environmental Sciences, Walter Sisulu University, Mthatha, South AfricaDepartment of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, GhanaDepartment of Biological and Environmental Sciences, Walter Sisulu University, Mthatha, South AfricaBackground Limited longitudinal data exist on chronic kidney disease (CKD) in African populations undergoing epidemiological transitions. We investigated incidence, long-term predictors and progression of CKD among Ghanaians residing in Ghana and Ghanaian migrants in the Netherlands (Amsterdam).Methods and findings We analysed data from 2183 participants in the transcontinental population-based prospective Research on Obesity and Diabetes among African Migrants cohort, followed for approximately 7 years. CKD incidence and its progression to end-stage kidney disease (ESKD) were defined using Kidney Disease: Improving Global Outcomes (KDIGO) criteria. CKD incidence was calculated using age- and sex standardisation for those without CKD at baseline. Long-term predictors of CKD incidence were identified using one-step robust Poisson regression. CKD progression to ESKD from baseline was also assessed using robust Poisson regressions. Overall age- and sex standardised CKD incidence was 11.0% (95% CI 9.3% to 12.3%) in the population, with Ghanaians residing in Amsterdam at (7.6%; 5.7% to 9.5%) and Ghanaians residing in Ghana at (12.9%; 10.9% to 14.9%). Within Ghana, rural Ghanaians had similar CKD incidence to urban Ghanaians (12.5%; 8.5% to 15.5% vs 12.3%; 8.2% to 15.8%). Residence in Amsterdam was associated with lower CKD incidence compared with Ghana after adjustments (incidence rate ratio=0.32; 0.13–0.77). CKD incidence predictors were advanced age, female sex, alcohol consumption, uric acid levels and hypertension. CKD progression to ESKD was 2.3% among Ghanaians residing in Ghana and 0.0% among Ghanaians residing in Amsterdam.Conclusion One-tenth of Ghanaians developed CKD over 7 years, with higher incidence in Ghana compared with Europe. Age, female sex, alcohol use, uric acid levels and hypertension were predictive factors. CKD progression to ESKD was minimal. High CKD incidence among Ghanaians, especially those residing in Ghana, calls for in-depth assessment of contributing factors and targeted interventions.https://gh.bmj.com/content/10/1/e016786.full |
| spellingShingle | Charles Agyemang Ellis Owusu-Dabo Erik Beune Karlijn Meeks Bert-Jan H van den Born Liffert Vogt Felix P Chilunga Charles F Hayfron-Benjamin Sampson Twumasi-Ankrah Muhulo Muhau Mungamba Eva L van der Linden Engwa A Godwill Samuel N Darko Benedicta N Chungag Incidence, long-term predictors and progression of chronic kidney disease among African migrants and non-migrants: the transcontinental population-based prospective RODAM cohort study BMJ Global Health |
| title | Incidence, long-term predictors and progression of chronic kidney disease among African migrants and non-migrants: the transcontinental population-based prospective RODAM cohort study |
| title_full | Incidence, long-term predictors and progression of chronic kidney disease among African migrants and non-migrants: the transcontinental population-based prospective RODAM cohort study |
| title_fullStr | Incidence, long-term predictors and progression of chronic kidney disease among African migrants and non-migrants: the transcontinental population-based prospective RODAM cohort study |
| title_full_unstemmed | Incidence, long-term predictors and progression of chronic kidney disease among African migrants and non-migrants: the transcontinental population-based prospective RODAM cohort study |
| title_short | Incidence, long-term predictors and progression of chronic kidney disease among African migrants and non-migrants: the transcontinental population-based prospective RODAM cohort study |
| title_sort | incidence long term predictors and progression of chronic kidney disease among african migrants and non migrants the transcontinental population based prospective rodam cohort study |
| url | https://gh.bmj.com/content/10/1/e016786.full |
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