Evaluation of Wide Corneal Epithelial Remodeling after Small Incision Lenticule Extraction (SMILE) with Wide-Field Optical Coherence Tomography
Purpose. This study aims to assess the corneal epithelial remodeling within a 9 mm diameter zone induced by small incision lenticule extraction (SMILE) and evaluate its relationship with the refractive outcomes. Methods. A total of 64 eyes of 64 patients were included. Wide-field optical coherence t...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2022/8764103 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564895622627328 |
|---|---|
| author | Yiming Ye Pei Chen Na Yu Linxi Wan Min Lan Hua Zheng Keming Yu |
| author_facet | Yiming Ye Pei Chen Na Yu Linxi Wan Min Lan Hua Zheng Keming Yu |
| author_sort | Yiming Ye |
| collection | DOAJ |
| description | Purpose. This study aims to assess the corneal epithelial remodeling within a 9 mm diameter zone induced by small incision lenticule extraction (SMILE) and evaluate its relationship with the refractive outcomes. Methods. A total of 64 eyes of 64 patients were included. Wide-field optical coherence tomography (OCT) was used to measure the epithelial thickness (ET) across a 9 mm diameter area, preoperatively, and after one day, one week, one month, three months, and six months postoperatively. The ET changes were compared among the different time points and analyzed zones. Results. The ET increases from one week to three months and stabilized from three months to six months. Compared to the preoperative values, the mean ET changes at six months in central (2 mm), paracentral (2–5 mm), mid-peripheral (5–7 mm), and peripheral (7–9 mm) zones were 4.37, 4.36, 1.61, and −1.59 μm, respectively. The correlation between the epithelial thickening and the amount of myopia correction was positive in central (P = 0.001) and paracentral zones (P < 0.001) and negative in peripheral zone (P = 0.006). The intended diameter of the optical zone was negatively related to epithelial hyperplasia in the central (P = 0.020) and paracentral zone (P = 0.006), and the correlation was positive in the mid-peripheral zone (P = 0.001). The epithelial thickening of central zone (P = 0.012) and the difference of mean ET between central and paracentral zone (P = 0.020) were negatively related to the spherical equivalent at six months. Conclusion. An asymmetric lenticule-like pattern of epithelial remodeling occurred in 9 mm diameter cornea at six months after myopic SMILE. The epithelial remodeling may affect the refractive outcomes of SMILE. |
| format | Article |
| id | doaj-art-83059a44b32a41e9bac2a1034edfd9df |
| institution | Kabale University |
| issn | 2090-0058 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-83059a44b32a41e9bac2a1034edfd9df2025-02-03T01:09:55ZengWileyJournal of Ophthalmology2090-00582022-01-01202210.1155/2022/8764103Evaluation of Wide Corneal Epithelial Remodeling after Small Incision Lenticule Extraction (SMILE) with Wide-Field Optical Coherence TomographyYiming Ye0Pei Chen1Na Yu2Linxi Wan3Min Lan4Hua Zheng5Keming Yu6State Key Laboratory of OphthalmologyState Key Laboratory of OphthalmologyState Key Laboratory of OphthalmologyState Key Laboratory of OphthalmologyState Key Laboratory of OphthalmologyState Key Laboratory of OphthalmologyState Key Laboratory of OphthalmologyPurpose. This study aims to assess the corneal epithelial remodeling within a 9 mm diameter zone induced by small incision lenticule extraction (SMILE) and evaluate its relationship with the refractive outcomes. Methods. A total of 64 eyes of 64 patients were included. Wide-field optical coherence tomography (OCT) was used to measure the epithelial thickness (ET) across a 9 mm diameter area, preoperatively, and after one day, one week, one month, three months, and six months postoperatively. The ET changes were compared among the different time points and analyzed zones. Results. The ET increases from one week to three months and stabilized from three months to six months. Compared to the preoperative values, the mean ET changes at six months in central (2 mm), paracentral (2–5 mm), mid-peripheral (5–7 mm), and peripheral (7–9 mm) zones were 4.37, 4.36, 1.61, and −1.59 μm, respectively. The correlation between the epithelial thickening and the amount of myopia correction was positive in central (P = 0.001) and paracentral zones (P < 0.001) and negative in peripheral zone (P = 0.006). The intended diameter of the optical zone was negatively related to epithelial hyperplasia in the central (P = 0.020) and paracentral zone (P = 0.006), and the correlation was positive in the mid-peripheral zone (P = 0.001). The epithelial thickening of central zone (P = 0.012) and the difference of mean ET between central and paracentral zone (P = 0.020) were negatively related to the spherical equivalent at six months. Conclusion. An asymmetric lenticule-like pattern of epithelial remodeling occurred in 9 mm diameter cornea at six months after myopic SMILE. The epithelial remodeling may affect the refractive outcomes of SMILE.http://dx.doi.org/10.1155/2022/8764103 |
| spellingShingle | Yiming Ye Pei Chen Na Yu Linxi Wan Min Lan Hua Zheng Keming Yu Evaluation of Wide Corneal Epithelial Remodeling after Small Incision Lenticule Extraction (SMILE) with Wide-Field Optical Coherence Tomography Journal of Ophthalmology |
| title | Evaluation of Wide Corneal Epithelial Remodeling after Small Incision Lenticule Extraction (SMILE) with Wide-Field Optical Coherence Tomography |
| title_full | Evaluation of Wide Corneal Epithelial Remodeling after Small Incision Lenticule Extraction (SMILE) with Wide-Field Optical Coherence Tomography |
| title_fullStr | Evaluation of Wide Corneal Epithelial Remodeling after Small Incision Lenticule Extraction (SMILE) with Wide-Field Optical Coherence Tomography |
| title_full_unstemmed | Evaluation of Wide Corneal Epithelial Remodeling after Small Incision Lenticule Extraction (SMILE) with Wide-Field Optical Coherence Tomography |
| title_short | Evaluation of Wide Corneal Epithelial Remodeling after Small Incision Lenticule Extraction (SMILE) with Wide-Field Optical Coherence Tomography |
| title_sort | evaluation of wide corneal epithelial remodeling after small incision lenticule extraction smile with wide field optical coherence tomography |
| url | http://dx.doi.org/10.1155/2022/8764103 |
| work_keys_str_mv | AT yimingye evaluationofwidecornealepithelialremodelingaftersmallincisionlenticuleextractionsmilewithwidefieldopticalcoherencetomography AT peichen evaluationofwidecornealepithelialremodelingaftersmallincisionlenticuleextractionsmilewithwidefieldopticalcoherencetomography AT nayu evaluationofwidecornealepithelialremodelingaftersmallincisionlenticuleextractionsmilewithwidefieldopticalcoherencetomography AT linxiwan evaluationofwidecornealepithelialremodelingaftersmallincisionlenticuleextractionsmilewithwidefieldopticalcoherencetomography AT minlan evaluationofwidecornealepithelialremodelingaftersmallincisionlenticuleextractionsmilewithwidefieldopticalcoherencetomography AT huazheng evaluationofwidecornealepithelialremodelingaftersmallincisionlenticuleextractionsmilewithwidefieldopticalcoherencetomography AT kemingyu evaluationofwidecornealepithelialremodelingaftersmallincisionlenticuleextractionsmilewithwidefieldopticalcoherencetomography |