Paraneoplastic Autoimmunity Associated with Testicular Myeloid Sarcoma and Chronic Myelomonocytic Leukemia

Myeloid sarcomas are rare extramedullary solid tumors composed of immature myeloid cells. The clinical presentations of these malignant neoplasms are highly variable, ranging from asymptomatic to localized mass effect. Here, we report an unusual case of myeloid sarcoma of the testis found in associa...

Full description

Saved in:
Bibliographic Details
Main Authors: Jeffrey W. Craig, Richard J. Lin
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Case Reports in Hematology
Online Access:http://dx.doi.org/10.1155/2013/656543
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1832552023281631232
author Jeffrey W. Craig
Richard J. Lin
author_facet Jeffrey W. Craig
Richard J. Lin
author_sort Jeffrey W. Craig
collection DOAJ
description Myeloid sarcomas are rare extramedullary solid tumors composed of immature myeloid cells. The clinical presentations of these malignant neoplasms are highly variable, ranging from asymptomatic to localized mass effect. Here, we report an unusual case of myeloid sarcoma of the testis found in association with chronic myelomonocytic leukemia where the presenting symptoms were autoimmune pericarditis and migratory arthralgias and myalgias that preceded testicular enlargement by nearly three months. Treatment with both radical orchiectomy and leukemia-directed chemotherapy led to immediate reductions in symptom severity, suggesting that these early symptoms were paraneoplastic in origin. Review of the literature identified the association between hematological malignancies, including chronic myelomonocytic leukemia, and paraneoplastic autoimmune phenomena with features similar to polymyalgia rheumatica and rheumatoid arthritis. Importantly, rheumatologic symptoms related to these disease entities may be easily dismissed as vague or unrelated complaints or treated as purely rheumatologic conditions, thus delaying the formal diagnoses. Clinicians must recognize the common association between possible paraneoplastic rheumatologic symptoms and hematologic malignancies such as chronic myelomonocytic leukemia.
format Article
id doaj-art-830207ef057248c9bf3ab40773236609
institution Kabale University
issn 2090-6560
2090-6579
language English
publishDate 2013-01-01
publisher Wiley
record_format Article
series Case Reports in Hematology
spelling doaj-art-830207ef057248c9bf3ab407732366092025-02-03T05:59:46ZengWileyCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/656543656543Paraneoplastic Autoimmunity Associated with Testicular Myeloid Sarcoma and Chronic Myelomonocytic LeukemiaJeffrey W. Craig0Richard J. Lin1Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD-PhD Program, 1300 York Avenue, Room C-103, New York, NY 10065, USADepartment of Medicine, Weill Cornell Medical College, 525 East 68th Street, P.O. Box 130, New York, NY 10065, USAMyeloid sarcomas are rare extramedullary solid tumors composed of immature myeloid cells. The clinical presentations of these malignant neoplasms are highly variable, ranging from asymptomatic to localized mass effect. Here, we report an unusual case of myeloid sarcoma of the testis found in association with chronic myelomonocytic leukemia where the presenting symptoms were autoimmune pericarditis and migratory arthralgias and myalgias that preceded testicular enlargement by nearly three months. Treatment with both radical orchiectomy and leukemia-directed chemotherapy led to immediate reductions in symptom severity, suggesting that these early symptoms were paraneoplastic in origin. Review of the literature identified the association between hematological malignancies, including chronic myelomonocytic leukemia, and paraneoplastic autoimmune phenomena with features similar to polymyalgia rheumatica and rheumatoid arthritis. Importantly, rheumatologic symptoms related to these disease entities may be easily dismissed as vague or unrelated complaints or treated as purely rheumatologic conditions, thus delaying the formal diagnoses. Clinicians must recognize the common association between possible paraneoplastic rheumatologic symptoms and hematologic malignancies such as chronic myelomonocytic leukemia.http://dx.doi.org/10.1155/2013/656543
spellingShingle Jeffrey W. Craig
Richard J. Lin
Paraneoplastic Autoimmunity Associated with Testicular Myeloid Sarcoma and Chronic Myelomonocytic Leukemia
Case Reports in Hematology
title Paraneoplastic Autoimmunity Associated with Testicular Myeloid Sarcoma and Chronic Myelomonocytic Leukemia
title_full Paraneoplastic Autoimmunity Associated with Testicular Myeloid Sarcoma and Chronic Myelomonocytic Leukemia
title_fullStr Paraneoplastic Autoimmunity Associated with Testicular Myeloid Sarcoma and Chronic Myelomonocytic Leukemia
title_full_unstemmed Paraneoplastic Autoimmunity Associated with Testicular Myeloid Sarcoma and Chronic Myelomonocytic Leukemia
title_short Paraneoplastic Autoimmunity Associated with Testicular Myeloid Sarcoma and Chronic Myelomonocytic Leukemia
title_sort paraneoplastic autoimmunity associated with testicular myeloid sarcoma and chronic myelomonocytic leukemia
url http://dx.doi.org/10.1155/2013/656543
work_keys_str_mv AT jeffreywcraig paraneoplasticautoimmunityassociatedwithtesticularmyeloidsarcomaandchronicmyelomonocyticleukemia
AT richardjlin paraneoplasticautoimmunityassociatedwithtesticularmyeloidsarcomaandchronicmyelomonocyticleukemia