Comparative evaluation of immunomodulatory cytokines for oncolytic therapy based on a high-efficient platform for oHSV1 reconstruction

Comparative evaluation of immunomodulatory cytokines for oncolytic therapy based on a high-efficient platform for oHSV1 reconstruction

Abstract Background Triple-negative breast cancer (TNBC) presents significant therapeutic challenges due to its immunosuppressive tumor microenvironment (TME). Oncolytic herpes simplex virus type 1 (oHSV1) offers dual mechanisms of tumor lysis and immune activation, yet the optimal cytokine payloads...

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Bibliographic Details
Main Authors: Yingzheng Gao, Yufang Zou, Changjing Wu, Juan Tao, Zuqing Nie, Jinyuan Yan, Pengfei Wang, Xinwei Huang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Virology Journal
Subjects:
Oncolytic virus
HSV-1
Immunomodulatory cytokines
GM-CSF
IFN-γ
IL15Rα/IL15 fusion protein
Online Access:https://doi.org/10.1186/s12985-025-02758-y
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