Recommendations for Management of Patients with Carotid Stenosis

Stroke is a one of the leading causes of morbidity and mortality in the world. Carotid atherosclerosis is recognized as an important factor in stroke pathophysiology and represents a key target in stroke prevention; multiple treatment modalities have been developed to battle this disease. Multiple r...

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Main Authors: Arijana Lovrencic-Huzjan, Tatjana Rundek, Michael Katsnelson
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Stroke Research and Treatment
Online Access:http://dx.doi.org/10.1155/2012/175869
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author Arijana Lovrencic-Huzjan
Tatjana Rundek
Michael Katsnelson
author_facet Arijana Lovrencic-Huzjan
Tatjana Rundek
Michael Katsnelson
author_sort Arijana Lovrencic-Huzjan
collection DOAJ
description Stroke is a one of the leading causes of morbidity and mortality in the world. Carotid atherosclerosis is recognized as an important factor in stroke pathophysiology and represents a key target in stroke prevention; multiple treatment modalities have been developed to battle this disease. Multiple randomized trials have shown the efficacy of carotid endarterectomy in secondary stroke prevention. Carotid stenting, a newer treatment option, presents a less invasive alternative to the surgical intervention on carotid arteries. Advances in medical therapy have also enabled further risk reduction in the overall incidence of stroke. Despite numerous trials and decades of clinical research, the optimal management of symptomatic and asymptomatic carotid disease remains controversial. We will attempt to highlight some of the pivotal trials already completed, discuss the current controversies and complexities in the treatment decision-making, and postulate on what likely lies ahead. This paper will highlight the complexities of decision-making optimal treatment recommendations for patients with symptomatic and asymptomatic carotid stenosis.
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spelling doaj-art-82fd2d51af2a4ae0b071789408914cde2025-02-03T01:01:41ZengWileyStroke Research and Treatment2090-81052042-00562012-01-01201210.1155/2012/175869175869Recommendations for Management of Patients with Carotid StenosisArijana Lovrencic-Huzjan0Tatjana Rundek1Michael Katsnelson2University Department of Neurology, University Hospital Center “Sisters of Mercy,” 10000 Zagreb, CroatiaClinical Translational Research Division, Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USADepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USAStroke is a one of the leading causes of morbidity and mortality in the world. Carotid atherosclerosis is recognized as an important factor in stroke pathophysiology and represents a key target in stroke prevention; multiple treatment modalities have been developed to battle this disease. Multiple randomized trials have shown the efficacy of carotid endarterectomy in secondary stroke prevention. Carotid stenting, a newer treatment option, presents a less invasive alternative to the surgical intervention on carotid arteries. Advances in medical therapy have also enabled further risk reduction in the overall incidence of stroke. Despite numerous trials and decades of clinical research, the optimal management of symptomatic and asymptomatic carotid disease remains controversial. We will attempt to highlight some of the pivotal trials already completed, discuss the current controversies and complexities in the treatment decision-making, and postulate on what likely lies ahead. This paper will highlight the complexities of decision-making optimal treatment recommendations for patients with symptomatic and asymptomatic carotid stenosis.http://dx.doi.org/10.1155/2012/175869
spellingShingle Arijana Lovrencic-Huzjan
Tatjana Rundek
Michael Katsnelson
Recommendations for Management of Patients with Carotid Stenosis
Stroke Research and Treatment
title Recommendations for Management of Patients with Carotid Stenosis
title_full Recommendations for Management of Patients with Carotid Stenosis
title_fullStr Recommendations for Management of Patients with Carotid Stenosis
title_full_unstemmed Recommendations for Management of Patients with Carotid Stenosis
title_short Recommendations for Management of Patients with Carotid Stenosis
title_sort recommendations for management of patients with carotid stenosis
url http://dx.doi.org/10.1155/2012/175869
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