Burden of heart failure attributable to chronic kidney disease in older adults (1990–2021): an analysis from the global burden of disease study
BackgroundHeart failure (HF) is a critical global health issue, with chronic kidney disease (CKD) as a significant contributing factor. Both primarily affect older adults, with prevalence rising substantially after age 60. This study examined global trends and disparities in CKD-associated HF among...
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Frontiers Media S.A.
2025-06-01
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| author | Wenli Liu Lin Huang Yaohua Shen Lingling Xu Wenhua Gu Zhaoyu Lu |
| author_facet | Wenli Liu Lin Huang Yaohua Shen Lingling Xu Wenhua Gu Zhaoyu Lu |
| author_sort | Wenli Liu |
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| description | BackgroundHeart failure (HF) is a critical global health issue, with chronic kidney disease (CKD) as a significant contributing factor. Both primarily affect older adults, with prevalence rising substantially after age 60. This study examined global trends and disparities in CKD-associated HF among older adults from 1990 to 2021.MethodsUtilizing data from the Global Burden of Disease (GBD) 2021, the study analyzed the prevalence and years lived with disability (YLDs) of CKD-associated HF. Joinpoint regression assessed trends from 1990 to 2021 globally, regionally, and nationally. Health inequity analysis, including the slope index of inequality and health inequality concentration index, evaluated disparities across countries.ResultsFrom 1990 to 2021, the prevalence and YLDs of CKD-associated HF increased globally, with an average annual percentage change (AAPC) of 2.21% [95% confidence interval (CI), 2.17–2.25] and 2.20% (95% CI, 2.16–2.24), respectively. Males exhibited higher prevalence and YLDs but demonstrated a slower increase than females. The low-SDI region exhibited the highest burden, while the high-SDI region showed an unfavorable increase. Socioeconomic disparities were decreased but persisted. From 1990 to 2021, the inequality slope index for prevalence decreased from 143.66 (95% CI, 167.68–119.65) to 114.12 (95% CI, 151.59–76.65), whereas the health inequality concentration index improved from −0.21 (95% CI, −0.30 to −0.12) to −0.07 (95% CI, −0.14 to 0) for prevalence.ConclusionThe global burden of CKD-associated HF has increased substantially, with persistent disparities across gender and SDI levels. Strengthening preventive measures and implementing effective interventions are essential to addressing this escalating health challenge. |
| format | Article |
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| institution | DOAJ |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Public Health |
| spelling | doaj-art-82faac8aa51747bf942f2ce9f8b3ad412025-08-20T02:40:29ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-06-011310.3389/fpubh.2025.16067191606719Burden of heart failure attributable to chronic kidney disease in older adults (1990–2021): an analysis from the global burden of disease studyWenli Liu0Lin Huang1Yaohua Shen2Lingling Xu3Wenhua Gu4Zhaoyu Lu5The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Cardiology, Guangdong Provincial People’s Hospital, Southern Medical University, Guangzhou, ChinaThe Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Nephrology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaBackgroundHeart failure (HF) is a critical global health issue, with chronic kidney disease (CKD) as a significant contributing factor. Both primarily affect older adults, with prevalence rising substantially after age 60. This study examined global trends and disparities in CKD-associated HF among older adults from 1990 to 2021.MethodsUtilizing data from the Global Burden of Disease (GBD) 2021, the study analyzed the prevalence and years lived with disability (YLDs) of CKD-associated HF. Joinpoint regression assessed trends from 1990 to 2021 globally, regionally, and nationally. Health inequity analysis, including the slope index of inequality and health inequality concentration index, evaluated disparities across countries.ResultsFrom 1990 to 2021, the prevalence and YLDs of CKD-associated HF increased globally, with an average annual percentage change (AAPC) of 2.21% [95% confidence interval (CI), 2.17–2.25] and 2.20% (95% CI, 2.16–2.24), respectively. Males exhibited higher prevalence and YLDs but demonstrated a slower increase than females. The low-SDI region exhibited the highest burden, while the high-SDI region showed an unfavorable increase. Socioeconomic disparities were decreased but persisted. From 1990 to 2021, the inequality slope index for prevalence decreased from 143.66 (95% CI, 167.68–119.65) to 114.12 (95% CI, 151.59–76.65), whereas the health inequality concentration index improved from −0.21 (95% CI, −0.30 to −0.12) to −0.07 (95% CI, −0.14 to 0) for prevalence.ConclusionThe global burden of CKD-associated HF has increased substantially, with persistent disparities across gender and SDI levels. Strengthening preventive measures and implementing effective interventions are essential to addressing this escalating health challenge.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1606719/fullheart failurechronic kidney diseasedisease burdentrendshealth inequalities |
| spellingShingle | Wenli Liu Lin Huang Yaohua Shen Lingling Xu Wenhua Gu Zhaoyu Lu Burden of heart failure attributable to chronic kidney disease in older adults (1990–2021): an analysis from the global burden of disease study Frontiers in Public Health heart failure chronic kidney disease disease burden trends health inequalities |
| title | Burden of heart failure attributable to chronic kidney disease in older adults (1990–2021): an analysis from the global burden of disease study |
| title_full | Burden of heart failure attributable to chronic kidney disease in older adults (1990–2021): an analysis from the global burden of disease study |
| title_fullStr | Burden of heart failure attributable to chronic kidney disease in older adults (1990–2021): an analysis from the global burden of disease study |
| title_full_unstemmed | Burden of heart failure attributable to chronic kidney disease in older adults (1990–2021): an analysis from the global burden of disease study |
| title_short | Burden of heart failure attributable to chronic kidney disease in older adults (1990–2021): an analysis from the global burden of disease study |
| title_sort | burden of heart failure attributable to chronic kidney disease in older adults 1990 2021 an analysis from the global burden of disease study |
| topic | heart failure chronic kidney disease disease burden trends health inequalities |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1606719/full |
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