Avoiding broadband radiation damping effects in NOESY spectra
Radiation damping is a well-known phenomenon in the context of NMR spectroscopy. Several strategies exist for minimizing the effects of radiation damping, which have mostly been focused on limiting the effects of one resonance (frequently the water resonance). When samples with many resonances are e...
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Elsevier
2025-06-01
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| Series: | Journal of Magnetic Resonance Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666441025000196 |
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| author | Kelsey Anne Marr Alexej Jerschow |
| author_facet | Kelsey Anne Marr Alexej Jerschow |
| author_sort | Kelsey Anne Marr |
| collection | DOAJ |
| description | Radiation damping is a well-known phenomenon in the context of NMR spectroscopy. Several strategies exist for minimizing the effects of radiation damping, which have mostly been focused on limiting the effects of one resonance (frequently the water resonance). When samples with many resonances are examined at high concentration, such approaches often cannot be used. One category of systems where the broadband nature of radiation damping leads to complications are deep eutectic solvents (DESs). DESs are considered innovative solvent systems that have several advantages such as tunability and environmental friendliness, with important applications ranging from catalysis to drug delivery. It is of interest to examine the intermolecular effects via NMR spectroscopy in these systems. Here we show that broadband radiation effects are very strong in these systems and identify simple strategies specifically for 2D NOESY NMR spectroscopy to regain the ability to quantify intermolecular interactions in these systems. |
| format | Article |
| id | doaj-art-82fa472b26d64cce9ec50c09b352fbf3 |
| institution | DOAJ |
| issn | 2666-4410 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Magnetic Resonance Open |
| spelling | doaj-art-82fa472b26d64cce9ec50c09b352fbf32025-08-20T03:10:39ZengElsevierJournal of Magnetic Resonance Open2666-44102025-06-012310020310.1016/j.jmro.2025.100203Avoiding broadband radiation damping effects in NOESY spectraKelsey Anne Marr0Alexej Jerschow1Department of Chemistry, New York University, 100 Washington Square East, 10003, NY, USACorresponding author.; Department of Chemistry, New York University, 100 Washington Square East, 10003, NY, USARadiation damping is a well-known phenomenon in the context of NMR spectroscopy. Several strategies exist for minimizing the effects of radiation damping, which have mostly been focused on limiting the effects of one resonance (frequently the water resonance). When samples with many resonances are examined at high concentration, such approaches often cannot be used. One category of systems where the broadband nature of radiation damping leads to complications are deep eutectic solvents (DESs). DESs are considered innovative solvent systems that have several advantages such as tunability and environmental friendliness, with important applications ranging from catalysis to drug delivery. It is of interest to examine the intermolecular effects via NMR spectroscopy in these systems. Here we show that broadband radiation effects are very strong in these systems and identify simple strategies specifically for 2D NOESY NMR spectroscopy to regain the ability to quantify intermolecular interactions in these systems.http://www.sciencedirect.com/science/article/pii/S2666441025000196Radiation dampingDeep eutectic solvents2D NOESY NMR |
| spellingShingle | Kelsey Anne Marr Alexej Jerschow Avoiding broadband radiation damping effects in NOESY spectra Journal of Magnetic Resonance Open Radiation damping Deep eutectic solvents 2D NOESY NMR |
| title | Avoiding broadband radiation damping effects in NOESY spectra |
| title_full | Avoiding broadband radiation damping effects in NOESY spectra |
| title_fullStr | Avoiding broadband radiation damping effects in NOESY spectra |
| title_full_unstemmed | Avoiding broadband radiation damping effects in NOESY spectra |
| title_short | Avoiding broadband radiation damping effects in NOESY spectra |
| title_sort | avoiding broadband radiation damping effects in noesy spectra |
| topic | Radiation damping Deep eutectic solvents 2D NOESY NMR |
| url | http://www.sciencedirect.com/science/article/pii/S2666441025000196 |
| work_keys_str_mv | AT kelseyannemarr avoidingbroadbandradiationdampingeffectsinnoesyspectra AT alexejjerschow avoidingbroadbandradiationdampingeffectsinnoesyspectra |