Antiviral immune responses in human reproductive tract: Pathogenic mechanisms and therapeutic implications
Viral reproductive tract infections (VRTIs) are a significant global health concern with severe consequences, including infertility, chronic pelvic pain, and increased risk of HIV transmission. Complex interplay between pathogens and the host immune system plays a critical role in the pathogenesis a...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Asian Pacific Journal of Tropical Medicine |
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| Online Access: | https://journals.lww.com/10.4103/apjtm.apjtm_491_24 |
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| author | Kim-Ling Chin Nurhafiza Zainal |
| author_facet | Kim-Ling Chin Nurhafiza Zainal |
| author_sort | Kim-Ling Chin |
| collection | DOAJ |
| description | Viral reproductive tract infections (VRTIs) are a significant global health concern with severe consequences, including infertility, chronic pelvic pain, and increased risk of HIV transmission. Complex interplay between pathogens and the host immune system plays a critical role in the pathogenesis and treatment of VRTIs. This review aims to provide a comprehensive overview of the multifaceted roles of the immune system in both contributing to and combating VRTIs. The review will also address the consequent perturbations in immune homeostasis and the implications for disease manifestation and progression. The interrelation between systemic immunity and local immune responses is discussed, providing insights into the challenges and breakthroughs in managing these infections. By providing a comprehensive overview of the mechanisms, implications, and therapeutic strategies associated with viral reproductive tract infections and immune dysfunction, this review also informs future research and clinical practice in this important area of reproductive health. |
| format | Article |
| id | doaj-art-82f9f879cb2e4fef9a1a74ad2dae6db4 |
| institution | DOAJ |
| issn | 2352-4146 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Medicine |
| spelling | doaj-art-82f9f879cb2e4fef9a1a74ad2dae6db42025-08-20T02:56:30ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Medicine2352-41462025-01-01182677610.4103/apjtm.apjtm_491_24Antiviral immune responses in human reproductive tract: Pathogenic mechanisms and therapeutic implicationsKim-Ling ChinNurhafiza ZainalViral reproductive tract infections (VRTIs) are a significant global health concern with severe consequences, including infertility, chronic pelvic pain, and increased risk of HIV transmission. Complex interplay between pathogens and the host immune system plays a critical role in the pathogenesis and treatment of VRTIs. This review aims to provide a comprehensive overview of the multifaceted roles of the immune system in both contributing to and combating VRTIs. The review will also address the consequent perturbations in immune homeostasis and the implications for disease manifestation and progression. The interrelation between systemic immunity and local immune responses is discussed, providing insights into the challenges and breakthroughs in managing these infections. By providing a comprehensive overview of the mechanisms, implications, and therapeutic strategies associated with viral reproductive tract infections and immune dysfunction, this review also informs future research and clinical practice in this important area of reproductive health.https://journals.lww.com/10.4103/apjtm.apjtm_491_24viral reproductive tract infections (vrtis)immune responsehuman papillomavirus (hpv)herpes simplex virus (hsv)cytomegalovirus (cmv)human immunodeficiency virus (hiv)zika virus (zikv)hepatitis b virus (hbv)hepatitis c virus (hcv) |
| spellingShingle | Kim-Ling Chin Nurhafiza Zainal Antiviral immune responses in human reproductive tract: Pathogenic mechanisms and therapeutic implications Asian Pacific Journal of Tropical Medicine viral reproductive tract infections (vrtis) immune response human papillomavirus (hpv) herpes simplex virus (hsv) cytomegalovirus (cmv) human immunodeficiency virus (hiv) zika virus (zikv) hepatitis b virus (hbv) hepatitis c virus (hcv) |
| title | Antiviral immune responses in human reproductive tract: Pathogenic mechanisms and therapeutic implications |
| title_full | Antiviral immune responses in human reproductive tract: Pathogenic mechanisms and therapeutic implications |
| title_fullStr | Antiviral immune responses in human reproductive tract: Pathogenic mechanisms and therapeutic implications |
| title_full_unstemmed | Antiviral immune responses in human reproductive tract: Pathogenic mechanisms and therapeutic implications |
| title_short | Antiviral immune responses in human reproductive tract: Pathogenic mechanisms and therapeutic implications |
| title_sort | antiviral immune responses in human reproductive tract pathogenic mechanisms and therapeutic implications |
| topic | viral reproductive tract infections (vrtis) immune response human papillomavirus (hpv) herpes simplex virus (hsv) cytomegalovirus (cmv) human immunodeficiency virus (hiv) zika virus (zikv) hepatitis b virus (hbv) hepatitis c virus (hcv) |
| url | https://journals.lww.com/10.4103/apjtm.apjtm_491_24 |
| work_keys_str_mv | AT kimlingchin antiviralimmuneresponsesinhumanreproductivetractpathogenicmechanismsandtherapeuticimplications AT nurhafizazainal antiviralimmuneresponsesinhumanreproductivetractpathogenicmechanismsandtherapeuticimplications |