Pharmacogenetics of hypoglycemic agents
Despite the increase in the number of hypoglycemic agents, 35%–40% of patients with diabetes are unable to achieve adequate glycemic control. One of the reasons is the genetic heterogeneity of diabetes mellitus, requiring different treatment approaches; however, the individual metabolic features and...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2015-12-01
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| Series: | Сахарный диабет |
| Subjects: | |
| Online Access: | https://www.dia-endojournals.ru/jour/article/view/7681 |
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| author | Irina Vladimirovna Kononenko Aleksandr Yuryevich Mayorov Ekaterina Olegovna Koksharova Marina Vladimirovna Shestakova |
| author_facet | Irina Vladimirovna Kononenko Aleksandr Yuryevich Mayorov Ekaterina Olegovna Koksharova Marina Vladimirovna Shestakova |
| author_sort | Irina Vladimirovna Kononenko |
| collection | DOAJ |
| description | Despite the increase in the number of hypoglycemic agents, 35%–40% of patients with diabetes are unable to achieve adequate glycemic control. One of the reasons is the genetic heterogeneity of diabetes mellitus, requiring different treatment approaches; however, the individual metabolic features and sensitivity to drugs also affect the therapeutic effectiveness. The review presents the main results of pharmacogenetic research of several antidiabetic drugs: metformin, sulfonylurea, agonists of glucagon-like peptide-1 and thiazolidinediones. |
| format | Article |
| id | doaj-art-82f953229ed34cbea404d841af9850cd |
| institution | DOAJ |
| issn | 2072-0351 2072-0378 |
| language | English |
| publishDate | 2015-12-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj-art-82f953229ed34cbea404d841af9850cd2025-08-20T03:09:03ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782015-12-01184283410.14341/DM76817279Pharmacogenetics of hypoglycemic agentsIrina Vladimirovna Kononenko0Aleksandr Yuryevich Mayorov1Ekaterina Olegovna Koksharova2Marina Vladimirovna Shestakova3Endocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research Centre; Sechenov First Moscow State Medical UniversityDespite the increase in the number of hypoglycemic agents, 35%–40% of patients with diabetes are unable to achieve adequate glycemic control. One of the reasons is the genetic heterogeneity of diabetes mellitus, requiring different treatment approaches; however, the individual metabolic features and sensitivity to drugs also affect the therapeutic effectiveness. The review presents the main results of pharmacogenetic research of several antidiabetic drugs: metformin, sulfonylurea, agonists of glucagon-like peptide-1 and thiazolidinediones.https://www.dia-endojournals.ru/jour/article/view/7681diabetes mellituspharmacogeneticshypoglycemic agents |
| spellingShingle | Irina Vladimirovna Kononenko Aleksandr Yuryevich Mayorov Ekaterina Olegovna Koksharova Marina Vladimirovna Shestakova Pharmacogenetics of hypoglycemic agents Сахарный диабет diabetes mellitus pharmacogenetics hypoglycemic agents |
| title | Pharmacogenetics of hypoglycemic agents |
| title_full | Pharmacogenetics of hypoglycemic agents |
| title_fullStr | Pharmacogenetics of hypoglycemic agents |
| title_full_unstemmed | Pharmacogenetics of hypoglycemic agents |
| title_short | Pharmacogenetics of hypoglycemic agents |
| title_sort | pharmacogenetics of hypoglycemic agents |
| topic | diabetes mellitus pharmacogenetics hypoglycemic agents |
| url | https://www.dia-endojournals.ru/jour/article/view/7681 |
| work_keys_str_mv | AT irinavladimirovnakononenko pharmacogeneticsofhypoglycemicagents AT aleksandryuryevichmayorov pharmacogeneticsofhypoglycemicagents AT ekaterinaolegovnakoksharova pharmacogeneticsofhypoglycemicagents AT marinavladimirovnashestakova pharmacogeneticsofhypoglycemicagents |