Clinical insights into duodenal-type follicular lymphoma: case series study
In Asia, widespread early detection through endoscopic screening has resulted in higher diagnosis rates of asymptomatic duodenal-type follicular lymphoma (DFL). However, no standardized guidelines exist for diagnosing and managing DFL, and ongoing debates persist regarding the optimal treatment stra...
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| Format: | Article |
| Language: | English |
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Korean Society of Gastrointestinal Endoscopy
2025-07-01
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| Series: | Clinical Endoscopy |
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| Online Access: | http://e-ce.org/upload/pdf/ce-2025-076.pdf |
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| author | A Reum Choe Ye Ji Jun Min-Sun Cho Chung Hyun Tae Sung-Ae Jung Ki-Nam Shim |
| author_facet | A Reum Choe Ye Ji Jun Min-Sun Cho Chung Hyun Tae Sung-Ae Jung Ki-Nam Shim |
| author_sort | A Reum Choe |
| collection | DOAJ |
| description | In Asia, widespread early detection through endoscopic screening has resulted in higher diagnosis rates of asymptomatic duodenal-type follicular lymphoma (DFL). However, no standardized guidelines exist for diagnosing and managing DFL, and ongoing debates persist regarding the optimal treatment strategies. This retrospective observational study was conducted between February 2018 and July 2024. Endoscopic examination revealed small whitish nodular lesions in the second portion of the duodenum. Seven patients (58.0%) underwent involved-site radiation therapy. Two patients (17.0%) with stage IV disease underwent chemotherapy with rituximab combined with cyclophosphamide, doxorubicin, vincristine, and prednisolone. Another two (17.0%) received chemotherapy with rituximab combined with cyclophosphamide, vincristine, and prednisone. One patient (8.0%) was treated with rituximab monotherapy. During a median follow-up of 30.2 months, no cases of disease progression were observed. Although radiation and chemotherapy are effective treatments, the slow progression of the disease may make a watch-and-wait strategy appropriate. |
| format | Article |
| id | doaj-art-82f79caa48da4c34b79b6b6b4ed8df2d |
| institution | Kabale University |
| issn | 2234-2400 2234-2443 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Korean Society of Gastrointestinal Endoscopy |
| record_format | Article |
| series | Clinical Endoscopy |
| spelling | doaj-art-82f79caa48da4c34b79b6b6b4ed8df2d2025-08-20T03:58:18ZengKorean Society of Gastrointestinal EndoscopyClinical Endoscopy2234-24002234-24432025-07-0158461261710.5946/ce.2025.0768057Clinical insights into duodenal-type follicular lymphoma: case series studyA Reum Choe0Ye Ji Jun1Min-Sun Cho2Chung Hyun Tae3Sung-Ae Jung4Ki-Nam Shim5 Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea Department of Pathology, Ewha Womans University College of Medicine, Seoul, Korea Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, KoreaIn Asia, widespread early detection through endoscopic screening has resulted in higher diagnosis rates of asymptomatic duodenal-type follicular lymphoma (DFL). However, no standardized guidelines exist for diagnosing and managing DFL, and ongoing debates persist regarding the optimal treatment strategies. This retrospective observational study was conducted between February 2018 and July 2024. Endoscopic examination revealed small whitish nodular lesions in the second portion of the duodenum. Seven patients (58.0%) underwent involved-site radiation therapy. Two patients (17.0%) with stage IV disease underwent chemotherapy with rituximab combined with cyclophosphamide, doxorubicin, vincristine, and prednisolone. Another two (17.0%) received chemotherapy with rituximab combined with cyclophosphamide, vincristine, and prednisone. One patient (8.0%) was treated with rituximab monotherapy. During a median follow-up of 30.2 months, no cases of disease progression were observed. Although radiation and chemotherapy are effective treatments, the slow progression of the disease may make a watch-and-wait strategy appropriate.http://e-ce.org/upload/pdf/ce-2025-076.pdfdiagnosisdrug therapyduodenumfollicular lymphomaradiation |
| spellingShingle | A Reum Choe Ye Ji Jun Min-Sun Cho Chung Hyun Tae Sung-Ae Jung Ki-Nam Shim Clinical insights into duodenal-type follicular lymphoma: case series study Clinical Endoscopy diagnosis drug therapy duodenum follicular lymphoma radiation |
| title | Clinical insights into duodenal-type follicular lymphoma: case series study |
| title_full | Clinical insights into duodenal-type follicular lymphoma: case series study |
| title_fullStr | Clinical insights into duodenal-type follicular lymphoma: case series study |
| title_full_unstemmed | Clinical insights into duodenal-type follicular lymphoma: case series study |
| title_short | Clinical insights into duodenal-type follicular lymphoma: case series study |
| title_sort | clinical insights into duodenal type follicular lymphoma case series study |
| topic | diagnosis drug therapy duodenum follicular lymphoma radiation |
| url | http://e-ce.org/upload/pdf/ce-2025-076.pdf |
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