Exercise and Ischemia-Activated Pathways in Limb Muscle Angiogenesis and Vascular Regeneration
Exercise has a profound effect on cardiovascular disease, particularly through vascular remodeling and regeneration. Peripheral artery disease (PAD) is one such cardiovascular condition that benefits from regular exercise or rehabilitative physical therapy in terms of slowing the progression of dise...
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Houston Methodist DeBakey Heart & Vascular Center
2023-11-01
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| Series: | Methodist DeBakey Cardiovascular Journal |
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| Online Access: | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1304 |
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| author | Vihang A. Narkar |
| author_facet | Vihang A. Narkar |
| author_sort | Vihang A. Narkar |
| collection | DOAJ |
| description | Exercise has a profound effect on cardiovascular disease, particularly through vascular remodeling and regeneration. Peripheral artery disease (PAD) is one such cardiovascular condition that benefits from regular exercise or rehabilitative physical therapy in terms of slowing the progression of disease and delaying amputations. Various rodent pre-clinical studies using models of PAD and exercise have shed light on molecular pathways of vascular regeneration. Here, I review key exercise-activated signaling pathways (nuclear receptors, kinases, and hypoxia inducible factors) in the skeletal muscle that drive paracrine regenerative angiogenesis. The rationale for highlighting the skeletal muscle is that it is the largest organ recruited during exercise. During exercise, skeletal muscle releases several myokines, including angiogenic factors and cytokines that drive tissue vascular regeneration via activation of endothelial cells, as well as by recruiting immune and endothelial progenitor cells. Some of these core exercise-activated pathways can be extrapolated to vascular regeneration in other organs. I also highlight future areas of exercise research (including metabolomics, single cell transcriptomics, and extracellular vesicle biology) to advance our understanding of how exercise induces vascular regeneration at the molecular level, and propose the idea of “exercise-mimicking” therapeutics for vascular recovery. |
| format | Article |
| id | doaj-art-82e2e000cb0f401bb83f4b68e5e142fa |
| institution | OA Journals |
| issn | 1947-6108 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Houston Methodist DeBakey Heart & Vascular Center |
| record_format | Article |
| series | Methodist DeBakey Cardiovascular Journal |
| spelling | doaj-art-82e2e000cb0f401bb83f4b68e5e142fa2025-08-20T02:22:16ZengHouston Methodist DeBakey Heart & Vascular CenterMethodist DeBakey Cardiovascular Journal1947-61082023-11-01195586810.14797/mdcvj.13041281Exercise and Ischemia-Activated Pathways in Limb Muscle Angiogenesis and Vascular RegenerationVihang A. Narkar0https://orcid.org/0000-0001-5574-083XBrown Foundation Institute of Molecular Medicine, McGovern Medical School, UTHealth, Houston, TexasExercise has a profound effect on cardiovascular disease, particularly through vascular remodeling and regeneration. Peripheral artery disease (PAD) is one such cardiovascular condition that benefits from regular exercise or rehabilitative physical therapy in terms of slowing the progression of disease and delaying amputations. Various rodent pre-clinical studies using models of PAD and exercise have shed light on molecular pathways of vascular regeneration. Here, I review key exercise-activated signaling pathways (nuclear receptors, kinases, and hypoxia inducible factors) in the skeletal muscle that drive paracrine regenerative angiogenesis. The rationale for highlighting the skeletal muscle is that it is the largest organ recruited during exercise. During exercise, skeletal muscle releases several myokines, including angiogenic factors and cytokines that drive tissue vascular regeneration via activation of endothelial cells, as well as by recruiting immune and endothelial progenitor cells. Some of these core exercise-activated pathways can be extrapolated to vascular regeneration in other organs. I also highlight future areas of exercise research (including metabolomics, single cell transcriptomics, and extracellular vesicle biology) to advance our understanding of how exercise induces vascular regeneration at the molecular level, and propose the idea of “exercise-mimicking” therapeutics for vascular recovery.https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1304exerciseangiogenesislimb ischemiaperipheral artery disease |
| spellingShingle | Vihang A. Narkar Exercise and Ischemia-Activated Pathways in Limb Muscle Angiogenesis and Vascular Regeneration Methodist DeBakey Cardiovascular Journal exercise angiogenesis limb ischemia peripheral artery disease |
| title | Exercise and Ischemia-Activated Pathways in Limb Muscle Angiogenesis and Vascular Regeneration |
| title_full | Exercise and Ischemia-Activated Pathways in Limb Muscle Angiogenesis and Vascular Regeneration |
| title_fullStr | Exercise and Ischemia-Activated Pathways in Limb Muscle Angiogenesis and Vascular Regeneration |
| title_full_unstemmed | Exercise and Ischemia-Activated Pathways in Limb Muscle Angiogenesis and Vascular Regeneration |
| title_short | Exercise and Ischemia-Activated Pathways in Limb Muscle Angiogenesis and Vascular Regeneration |
| title_sort | exercise and ischemia activated pathways in limb muscle angiogenesis and vascular regeneration |
| topic | exercise angiogenesis limb ischemia peripheral artery disease |
| url | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1304 |
| work_keys_str_mv | AT vihanganarkar exerciseandischemiaactivatedpathwaysinlimbmuscleangiogenesisandvascularregeneration |