Integrated research strategies for reproductive and developmental toxicology of real-world exposure: Integrating population epidemiology with in vivo and in vitro experiments
Humans are continuously exposed to large numbers of complex chemical mixtures at low doses in real-world environments, which may pose potential threats to health, particularly to reproductive and developmental health. Therefore, understanding real-world exposure—specifically, the effects of chemical...
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Lanzhou University Press
2025-03-01
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| Series: | 生物医学转化 |
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| Online Access: | http://swyxzh.ijournals.cn/swyxzh/article/html/20250113?st=article_issue |
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| author | Cheng Qianhui Li Sainan Wang Linlin |
| author_facet | Cheng Qianhui Li Sainan Wang Linlin |
| author_sort | Cheng Qianhui |
| collection | DOAJ |
| description | Humans are continuously exposed to large numbers of complex chemical mixtures at low doses in real-world environments, which may pose potential threats to health, particularly to reproductive and developmental health. Therefore, understanding real-world exposure—specifically, the effects of chemical mixtures at environmental concentrations on health and their underlying mechanisms—is crucial. This requires integrating population epidemiological data with in vivo and in vitro toxicological studies to establish an integrated research framework for assessing the health effects of real-world exposure to chemical mixtures at environmental concentrations. This review systematically examines recent advancements in evaluating the health effects of real-world chemical exposure, with a particular focus on methodologies for identifying and characterizing chemical mixtures suitable for in vivo and in vitro toxicological experiments. Additionally, it reviews the application of these strategies in reproductive and developmental toxicology research. These studies lay the foundation for refining an integrated research framework for real-world exposure health effects and provide scientific evidence for more precise reproductive and developmental health risk assessment and intervention strategies. |
| format | Article |
| id | doaj-art-82e16b3addc44da584bdb0dc0d028d48 |
| institution | DOAJ |
| issn | 2096-8965 |
| language | zho |
| publishDate | 2025-03-01 |
| publisher | Lanzhou University Press |
| record_format | Article |
| series | 生物医学转化 |
| spelling | doaj-art-82e16b3addc44da584bdb0dc0d028d482025-08-20T03:16:46ZzhoLanzhou University Press生物医学转化2096-89652025-03-0161788610.12287/j.issn.2096-8965.20250112Integrated research strategies for reproductive and developmental toxicology of real-world exposure: Integrating population epidemiology with in vivo and in vitro experimentsCheng Qianhui0Li Sainan1Wang Linlin2Institute of Reproductive and Child Health/National Health Commission Key Laboratoryof Reproductive Health (School of Public Health, Peking University) ,Department of Epidemiology and Biostatistics, School of Public Health, Peking University ,State Key Laboratory of Female Fertility Promotion, Peking University, Beijing 100191 , ChinaInstitute of Reproductive and Child Health/National Health Commission Key Laboratoryof Reproductive Health (School of Public Health, Peking University) ,Department of Epidemiology and Biostatistics, School of Public Health, Peking University ,State Key Laboratory of Female Fertility Promotion, Peking University, Beijing 100191 , ChinaInstitute of Reproductive and Child Health/National Health Commission Key Laboratoryof Reproductive Health (School of Public Health, Peking University) ,Department of Epidemiology and Biostatistics, School of Public Health, Peking University ,State Key Laboratory of Female Fertility Promotion, Peking University, Beijing 100191 , ChinaHumans are continuously exposed to large numbers of complex chemical mixtures at low doses in real-world environments, which may pose potential threats to health, particularly to reproductive and developmental health. Therefore, understanding real-world exposure—specifically, the effects of chemical mixtures at environmental concentrations on health and their underlying mechanisms—is crucial. This requires integrating population epidemiological data with in vivo and in vitro toxicological studies to establish an integrated research framework for assessing the health effects of real-world exposure to chemical mixtures at environmental concentrations. This review systematically examines recent advancements in evaluating the health effects of real-world chemical exposure, with a particular focus on methodologies for identifying and characterizing chemical mixtures suitable for in vivo and in vitro toxicological experiments. Additionally, it reviews the application of these strategies in reproductive and developmental toxicology research. These studies lay the foundation for refining an integrated research framework for real-world exposure health effects and provide scientific evidence for more precise reproductive and developmental health risk assessment and intervention strategies.http://swyxzh.ijournals.cn/swyxzh/article/html/20250113?st=article_issuereal-world exposurechemical mixtureenvironmental concentrationreproductive toxicitydevelopmental toxicity |
| spellingShingle | Cheng Qianhui Li Sainan Wang Linlin Integrated research strategies for reproductive and developmental toxicology of real-world exposure: Integrating population epidemiology with in vivo and in vitro experiments 生物医学转化 real-world exposure chemical mixture environmental concentration reproductive toxicity developmental toxicity |
| title | Integrated research strategies for reproductive and developmental toxicology of real-world exposure: Integrating population epidemiology with in vivo and in vitro experiments |
| title_full | Integrated research strategies for reproductive and developmental toxicology of real-world exposure: Integrating population epidemiology with in vivo and in vitro experiments |
| title_fullStr | Integrated research strategies for reproductive and developmental toxicology of real-world exposure: Integrating population epidemiology with in vivo and in vitro experiments |
| title_full_unstemmed | Integrated research strategies for reproductive and developmental toxicology of real-world exposure: Integrating population epidemiology with in vivo and in vitro experiments |
| title_short | Integrated research strategies for reproductive and developmental toxicology of real-world exposure: Integrating population epidemiology with in vivo and in vitro experiments |
| title_sort | integrated research strategies for reproductive and developmental toxicology of real world exposure integrating population epidemiology with in vivo and in vitro experiments |
| topic | real-world exposure chemical mixture environmental concentration reproductive toxicity developmental toxicity |
| url | http://swyxzh.ijournals.cn/swyxzh/article/html/20250113?st=article_issue |
| work_keys_str_mv | AT chengqianhui integratedresearchstrategiesforreproductiveanddevelopmentaltoxicologyofrealworldexposureintegratingpopulationepidemiologywithinvivoandinvitroexperiments AT lisainan integratedresearchstrategiesforreproductiveanddevelopmentaltoxicologyofrealworldexposureintegratingpopulationepidemiologywithinvivoandinvitroexperiments AT wanglinlin integratedresearchstrategiesforreproductiveanddevelopmentaltoxicologyofrealworldexposureintegratingpopulationepidemiologywithinvivoandinvitroexperiments |